Abstract:
:Calsenilin, a multifunctional Ca2+-binding protein, has been identified as an Alzheimer's disease-associated presenilin interactor. Here, we investigated the histochemical localization of calsenilin and its expression levels in the brains of sporadic Alzheimer's disease. Both messenger RNA and protein expression of calsenilin were observed in neurons of the cerebral cortex and hippocampus of control brains, and more intense staining was in Alzheimer's disease brains. Although calsenilin is primarily expressed in neurons, its immunoreactivity was also detected in reactive astrocytes of the Alzheimer's disease brains. In Alzheimer's disease brains, the caspase-derived fragment of calsenilin was only detected in cytosolic fraction. Our findings suggest that calsenilin overexpression in both neurons and reactive astrocytes may play an important role in apoptosis and in Alzheimer's disease pathology.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Jin JK,Choi JK,Wasco W,Buxbaum JD,Kozlowski PB,Carp RI,Kim YS,Choi EKdoi
10.1097/00001756-200504040-00007subject
Has Abstractpub_date
2005-04-04 00:00:00pages
451-5issue
5eissn
0959-4965issn
1473-558Xpii
00001756-200504040-00007journal_volume
16pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The present study was performed to examine how intention to learn and explicit knowledge in sequence learning are reflected in event-related potentials. Participants responded to numerals presented in a repeating order, which were replaced infrequently by deviant numerals. The participants were given incidental or int...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505120-00010
更新日期:2005-05-12 00:00:00
abstract::We localized the gene expression of angiotensin II receptor subtypes (AT1A, AT1B, and AT2) in 2-week-old rat brain by in situ hybridization using subtype specific riboprobes. AT1A receptor mRNA but not AT1B or AT2 receptor mRNA was expressed in the subfornical organ and paraventricular nucleus of the hypothalamus. AT1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199512150-00024
更新日期:1995-12-15 00:00:00
abstract::delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We have recently localized a receptor for THC in the forebrain and found in the caudate-putamen that its gene expression is modulated by glucocorticoids, dopamine and glutamate. Here, we report for the first time, using quantitative in s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199406020-00028
更新日期:1994-06-02 00:00:00
abstract::STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f242d3
更新日期:2007-12-03 00:00:00
abstract::We examined the neural correlates associated with a short gap between two identical pure tones (within-channel) and between two different tones (between-channel) in an odd-ball paradigm. Gap durations were selected such that a gap between identical tones was as discriminable as a gap between two different tones. Spati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200409150-00011
更新日期:2004-09-15 00:00:00
abstract::Music is an essential communication tool that can convey emotional information. Segmentation of a sound stream of music at event boundaries is necessary for identification and extraction of musical context and features. To investigate recognition of music termination structure, or cadence, we composed music sequences ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000160
更新日期:2014-07-09 00:00:00
abstract::Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308060-00027
更新日期:2003-08-06 00:00:00
abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200001170-00002
更新日期:2000-01-17 00:00:00
abstract::Cell death by apoptosis occurs in mature neurones of adult rat dentate gyrus following adrenalectomy. In these studies, apoptosis in the dentate gyrus was induced 3 days after adrenalectomy in male Fischer 344 rats ranging in age from 2-3 to 24-26 months. Glial fibrillary acidic protein and transforming growth factor-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199804200-00040
更新日期:1998-04-20 00:00:00
abstract::The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199905140-00040
更新日期:1999-05-14 00:00:00
abstract::Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we stud...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00013
更新日期:2001-05-25 00:00:00
abstract::Diffusion tensor imaging was used to measure regional differences in brain white matter microstructure (intravoxel coherence) and macrostructure (intervoxel coherence) and age-related differences between men and women. Neuropsychiatrically healthy men and women, spanning the adult age range, showed the same pattern of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200101220-00027
更新日期:2001-01-22 00:00:00
abstract::The hypothesis of a magnocellular channel deficit in dyslexia was tested. Subjects were 10-year-old dyslexics and normal readers. Psychophysical thresholds for luminance and chromatic contrasts were estimated using black and white and red and green sinusoidal gratings of various spatial frequencies, presented in stati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212200-00028
更新日期:2002-12-20 00:00:00
abstract::For the majority of neurones in cat striate cortex, the response to an optimal stimulus presented to one eye is suppressed when a stimulus of substantially different orientation is presented to the other eye. In order to determine the true orientational tuning of the underlying inhibitory interactions in the absence o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511000-00032
更新日期:1995-11-13 00:00:00
abstract::Wilson's disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in different population. This study aimed to examine the genotypes of the ATP7B mutant alleles in WD patients from Southern China. Genomic DN...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000216
更新日期:2014-10-01 00:00:00
abstract::Alpha-Synuclein is a major component of neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA), one of the alpha-synucleinopathies. Recent studies have shown that beta-synuclein, a homolog of alpha-synuclein, inhibits alpha-synuclein aggregation in vitro. We immunohistochemically examined the MSA b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00005
更新日期:2003-10-06 00:00:00
abstract::The temperature of the tail skin is an important factor determining tail-flick latency to noxious radiant heat in rats and mice. The temperature of the skin may also be important in determining the behavioural response in the formalin test. Morphine in low and moderate doses strongly affected the core and tail skin te...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199206000-00014
更新日期:1992-06-01 00:00:00
abstract::Neuroimaging techniques, such as fMRI, PET and near-infrared spectroscopy, monitor task-related neuronal activations in the brain indirectly through the associated neurovascular/metabolic responses. To assess the primary neuronal activations directly, magnetoencephalography was combined here with a mechanical modulati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00034
更新日期:2001-06-13 00:00:00
abstract::We previously reported that clusterin enhances astrocyte proliferation and extracellular signal-regulated kinase (ERK) activity. It, however, remains largely unknown how clusterin promotes cell growth. Here, we investigate the signaling pathway and related molecules underlying astrocyte proliferation by clusterin. Exo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283262df8
更新日期:2009-03-04 00:00:00
abstract::The effects of Type I adrenal steroid receptors in prolonging synaptic plasticity in the dentate gyrus of freely behaving rats was investigated. Rats were implanted with chronic, bilateral stimulating and recording electrodes in the perforant pathway and dentate gyrus, respectively, and adrenalectomized (ADX). After a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00067
更新日期:1994-12-20 00:00:00
abstract::Recently, there has been growing interest in the neurobiological role of some amygdalar neuromediators, such as GABA and orexins (ORX), that are responsible for stressful behaviors. Infusion of the major fear-related and panic-related basolateral amygdalar station, the lateral nucleus, with ORX-A and ORX-B, alone or i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000213
更新日期:2014-08-20 00:00:00
abstract::Semi-quantitative single cell RT-PCR techniques were used to determine the expression of mRNAs related to GABAergic and cholinergic neurotransmission in neurons of the rat globus pallidus and adjacent basal forebrain region. Neurons of the globus pallidus expressed relatively high levels of GAD67 and GABA vesicular tr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00004
更新日期:1998-06-22 00:00:00
abstract::We investigated the effect of nicotine, a nicotinic agonist, and D-cycloserine (DCS, a partial glycine-B agonist of the N-methyl-D-aspartate (NMDA) receptor complex) on aging-induced defects of water maze (WM) spatial navigation in rats. Nicotine (0.3 mg kg-1, s.c.) or DCS (10 mg kg-1, i.p.) enhanced acquisition of th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00024
更新日期:1997-02-10 00:00:00
abstract::S100B is a calcium binding protein from astrocytes that regulates protein phosphorylation by binding to substrates and protein kinases. S100B might also regulate protein phosphatases and this was investigated for protein phosphatase 2B (calcineurin). The results indicate that S100B (5-10 microM) increased the activity...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200402090-00021
更新日期:2004-02-09 00:00:00
abstract::The current study aimed to investigate the altered cerebellar-cerebral functional connectivity (FC) induced by radiotherapy to nasopharyngeal carcinoma (NPC) patients. Twenty-four NPC patients without treatment, and 35 NPC patients receiving radiotherapy underwent functional MRI scanning. Montreal cognitive assessment...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000813
更新日期:2017-08-16 00:00:00
abstract::Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001451
更新日期:2020-05-22 00:00:00
abstract::The effect of chronic treatment with vitamin E (VE) on acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, as assessed by striatal dopamine (DA) depletion, was studied. Male C57B1/6J mice were fed VE (48 mg kg-1 per day, intragastric) for 4, 8, or 12 weeks prior to administration of MPTP (...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199109000-00012
更新日期:1991-09-01 00:00:00
abstract::We examined the effect of stimulus interruption on dual component field EPSPs in the hippocampal CA1 region. Resuming test stimulation at 0.1 Hz after 10-60 min silent periods led to an increase of the response followed by a decline, involving AMPA and NMDA components to a similar extent. Similar changes were seen whe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00005
更新日期:1999-04-06 00:00:00
abstract::In this study we have used the transgenic mouse model Tg2576 to analyze the involvement of anomalous loss of regulation of cdk5 and the stress kinases JNK and p38 in brain neuronal death as related to neurodegenerative disorders such as Alzheimer's disease. Previous studies on hippocampal cells led us to the discovery...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312190-00023
更新日期:2003-12-19 00:00:00
abstract::Proteins of the postsynaptic density are implicated in mechanisms of synaptic plasticity. We examined involvement of PSD95 and alphaCaMkII in learning-dependent plastic changes of representational maps in somatosensory cortex of mice. The barrel cortex of mice was examined following a 3 day long classical conditioning...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00030
更新日期:2001-09-17 00:00:00