Abstract:
:Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we studied the neuroprotective effect of BDNF, NT-3, and NT-4 on the cell death of cortical motoneurons in an organotypic culture model after chronic mitochondrial inhibition with malonate. Our data show that NT-4 completely prevents malonate-induced toxicity, whereas BDNF or NT-3 had no neuroprotective effect. In clinical trials for ALS, predominantly focussed on the survival of spinal motoneurons, BDNF has already been tested with disappointing results; our results suggest that NT-4 may be a better neurotrophin to prevent motoneuron loss.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Van Westerlaak MG,Bär PR,Cools AR,Joosten EAdoi
10.1097/00001756-200105250-00013subject
Has Abstractpub_date
2001-05-25 00:00:00pages
1355-8issue
7eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The role of dopaminergic pathways in the retina in controlling the functional state of the pineal was investigated. Dopaminergic agents were injected into the eyes of dark-adapted chickens which were maintained in the dark. Changes in the activity of N-acetyltransferase (NAT) in the retina and pineal were then monitor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199502000-00010
更新日期:1995-02-15 00:00:00
abstract::A lexical decision experiment was conducted while event related potentials (ERPs) were recorded. The word frequency and the first syllable frequency of each word were manipulated. Results showed that, while high frequency words produced less negative amplitudes in the N400 time window than low frequency words, the inv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200403010-00032
更新日期:2004-03-01 00:00:00
abstract::The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma cor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000220131.24468.e7
更新日期:2006-06-26 00:00:00
abstract::Factors controlling proliferation and differentiation are crucial in advancement of neural cell-based experimental neurodegenerative therapies. In this regard, nicotinamide has been shown to determine the fate of neural cells, enhance neuralization, and influence DNA repair and apoptosis. This study investigated wheth...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000071
更新日期:2013-12-18 00:00:00
abstract::The present study examined the effects of cocaine-regulated and amphetamine-regulated transcript peptide (CARTp) fragment 55-102, on N-methyl-D-aspartate (NMDA)-mediated nociceptive transmission in vivo and in vitro. In-vivo experiments were conducted in Sprague-Dawley rats to evaluate the effects of CARTp on thermal ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200502280-00010
更新日期:2005-02-28 00:00:00
abstract::In contrast to mammals, the brains of teleost fish exhibit an enormous regenerative capacity following injury. Here, we have examined the potential role of vimentin in this wound healing. Fifteen days after application of a mechanical lesion to the corpus cerebelli in the teleost fish Apteronotus leptoryhnchus, the ar...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203040-00014
更新日期:2002-03-04 00:00:00
abstract::GPR39, an orphan G protein-coupled receptor, has been recently identified as the receptor for the bioactive peptide obestatin. Obestatin is secreted from the stomach and acts as an anti-appetite hormone. This activity is induced whether obestatin is administered intraperitoneally or intracerebroventricularly. GPR39 is...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000215779.76602.93
更新日期:2006-05-29 00:00:00
abstract::Gastrin-releasing peptide plays an important role in regulating the advanced functions of the brain including emotional behavior, learning and memory. What's more, gastrin-releasing peptide levels are also associated with the central nervous system diseases. Our previous study proposed that intraperitoneal injection o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001324
更新日期:2019-10-16 00:00:00
abstract::We investigated the effect of previous musical training on lateralization of language as indexed by the effects of reading aloud on the modulation of motor evoked potentials (MEPs) induced in the first dorsal interosseus muscles (FDI) by transcranial magnetic stimulation (TMS) of the primary motor cortex. We studied 1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00033
更新日期:2002-05-07 00:00:00
abstract::We constructed two replication-deficient recombinant adenovirus vectors coding human basic fibroblast growth factor (bFGF), one with and one without the interleukin-2 (IL-2) secretory signal sequence and examined their neurotrophic effects on primary neuronal cells in vitro. The primary neuronal cells were successfull...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006260-00039
更新日期:2000-06-26 00:00:00
abstract::The effect of temporal interference of physiological signals on time-lag effective connectivity, derived from a functional network connectivity tool box (FNC), was examined by a blood-oxygen-level-dependent functional MRI study of action. The known effect of physiological signals on time-lag FNC was verified by (a) co...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835b6edf
更新日期:2013-01-09 00:00:00
abstract::Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c1e2bf
更新日期:2007-06-11 00:00:00
abstract::Transgenic mouse strains were generated that overexpress human APP or clinical mutants of APP. All transgenic mouse strains that over-express APP displayed essentially the same phenotype of disturbed behaviour, differential glutamatergic responses, deficits in maintenance of long-term potentiation and premature death,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00004
更新日期:1998-11-16 00:00:00
abstract::In this study we investigated the utility of different MRI techniques for the detection and predictability of hemorrhagic transformation (HT) in a rat model of transient focal cerebral ischemia. Hemorrhagic infarction was reliably identified with gradient-echo sequences and developed between 2 and 7 days following the...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00025
更新日期:2001-02-12 00:00:00
abstract::Cell death by apoptosis occurs in mature neurones of adult rat dentate gyrus following adrenalectomy. In these studies, apoptosis in the dentate gyrus was induced 3 days after adrenalectomy in male Fischer 344 rats ranging in age from 2-3 to 24-26 months. Glial fibrillary acidic protein and transforming growth factor-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199804200-00040
更新日期:1998-04-20 00:00:00
abstract::Previously we found that musicians have significantly larger anterior corpus callosum (CC). In the current study, we intended to replicate and extend our previous results using a new and larger sample of gender-matched subjects (56 right-handed professional musicians and 56 age- and handedness-matched controls). We fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200302100-00009
更新日期:2003-02-10 00:00:00
abstract::This study reports on a 9-year-old girl who developed West syndrome and showed clinical features fulfilling the main revised diagnostic criteria for typical Rett syndrome (hand washing, severe cognitive impairment with absence of language, ataxic gait, progressive scoliosis and autistic features). Mutation analyses fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000337
更新日期:2015-03-25 00:00:00
abstract::Calcium increases induced by single action potentials in rat visual cortex layer II/III pyramidal neurons were shown to be augmented by muscarinic acetylcholine receptor (mAchR) stimulation. This augmentation was drastically reduced by intracellular injection of heparin but not ruthenium red, therefore involving inosi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002280-00022
更新日期:2000-02-28 00:00:00
abstract::High concentrations of local anesthetics are neurotoxic, but the mechanism for this neurotoxicity is obscure. Here, we report increased concentrations of glutamate in the cerebrospinal fluid after intrathecal injections of high concentrations of tetracaine (a local anesthetic). The peak concentrations of glutamate aft...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00039
更新日期:2000-04-07 00:00:00
abstract::Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00045
更新日期:1999-04-06 00:00:00
abstract::Hypoxic-ischemic brain damage (HIBD) occurs due to intrauterine hypoxia ischemia influencing the energy supply for fetal brain cells, which affects the metabolism of the brain to make the brain suffer a severe damage. Erythropoietin (EPO), which regulates hemacytopoiesis, is a kind of cytokine. EPO is sensitive to hyp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001194
更新日期:2019-03-06 00:00:00
abstract::Traumatic brain injury (TBI) is a major risk factor for Alzheimer's disease. Recent studies suggest that amyloid-beta (Aβ) deposit can be detected several years after TBI. However, it is unknown whether post-TBI Aβ deposits arise from short-term changes in Aβ metabolism or reflect a long-term sequela. To answer this q...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000748
更新日期:2017-03-22 00:00:00
abstract::Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We ex...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812210-00013
更新日期:1998-12-21 00:00:00
abstract::Inhibition, the process that overrides and reverses the execution of a thought, action, or emotion, is important in daily life. Sixteen healthy volunteers performed a parametrically modulated motor inhibition task during functional magnetic resonance imaging. Two results were observed: (1) increased error-related ante...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505120-00020
更新日期:2005-05-12 00:00:00
abstract::We investigated the expression for fibroblast growth factor-2 (FGF-2), in cultured rat cerebellar granule cells and its modulation by Ca2+ regulating agents. There were no significant differences in the levels of FGF-2 mRNA in cells cultured in high vs low K+. The expression of the trophic factor is induced by Ca2+ en...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00043
更新日期:2000-11-09 00:00:00
abstract::An anti-leptin polyclonal antiserum was used to detect leptin-immunoreactivity (-ir) in the central nervous system in rats. Leptin-ir was found in perikaryon and processes of neurons in the hypothalamus, including the paraventricular nucleus, and in several regions in the brainstem, including the nucleus of the solita...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00042
更新日期:1999-02-05 00:00:00
abstract::We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00055
更新日期:1996-01-31 00:00:00
abstract::Transplantation of olfactory ensheathing cells (OECs) into photochemically damaged rat spinal cord diminished astrocyte reactivity and parenchyma cavitation. The photochemical lesion performed at T12--L1 resulted in severe damage to the spinal cord, so that during the first 15 days postoperation all rats dragged their...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00005
更新日期:2001-08-08 00:00:00
abstract::Rats with an experimental painful peripheral neuropathy (the chronic injury (CCI) model) display heatevoked hyperalgesia. There is now considerable evidence that nitric oxide (NO) and nitric oxide synthase are involved in the development of hyperalgesia in acute inflammatory pain states. The mechanisms responsible for...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605310-00010
更新日期:1996-05-31 00:00:00
abstract::Neural cells have distinct responses to CNS injury; however, neural progenitor response to CNS injury is not yet documented. Stab injury combined with injection of bromodeoxyuridine (BrdU), a thymidine analog, into adult rat cortex above the lateral ventricle for 10 min resulted in activated microglia/macrophage infil...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908020-00012
更新日期:1999-08-02 00:00:00