Malonate-induced cortico-motoneuron death is attenuated by NT-4, but not by BDNF or NT-3.

Abstract:

:Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we studied the neuroprotective effect of BDNF, NT-3, and NT-4 on the cell death of cortical motoneurons in an organotypic culture model after chronic mitochondrial inhibition with malonate. Our data show that NT-4 completely prevents malonate-induced toxicity, whereas BDNF or NT-3 had no neuroprotective effect. In clinical trials for ALS, predominantly focussed on the survival of spinal motoneurons, BDNF has already been tested with disappointing results; our results suggest that NT-4 may be a better neurotrophin to prevent motoneuron loss.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Van Westerlaak MG,Bär PR,Cools AR,Joosten EA

doi

10.1097/00001756-200105250-00013

subject

Has Abstract

pub_date

2001-05-25 00:00:00

pages

1355-8

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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