S100B protein stimulates calcineurin activity.

abstract：:We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of...

journal_title：Neuroreport

authors： Shibata M,Araki N,Ohta K,Hamada J,Shimazu K,Fukuuchi Y

更新日期：1996-01-31 00:00:00

abstract：:Using NADPH-diaphorase (NADPH-d) histochemistry, the expression of nitric oxide synthase (NOS) was studied in the rat brain 1 week after kainate-induced status epilepticus. Major changes were observed in the hippocampi of epileptic animals, especially a loss of NADPH-d positive fibres in the periphery of degenerative ...

journal_title：Neuroreport

authors： Lerner-Natoli M,de Bock F,Bockaert J,Rondouin G

更新日期：1994-12-20 00:00:00

abstract：:Demyelinated CNS axons can be remyelinated by Schwann cells. A recent study concluded that with time Schwann cell remyelination is replaced by oligodendrocyte remyelination [9]. To examine this, the extent of Schwann cell and oligodendrocyte remyelination at 4, 6.5 and 24 weeks was determined for ethidium bromide lesi...

journal_title：Neuroreport

authors： Gilson JM,Blakemore WF

更新日期：2002-07-02 00:00:00

abstract：:Changes in nitric oxide (NO) concentration and cerebral blood flow (CBF) in the parietal cortex during hypercapnoea were investigated in anaesthetized rats, using a NO-selective electrode and laser Doppler flowmetry. When hypercapnoea was induced by inhalation of 5% CO2 for 10 min, both the NO concentration and CBF in...

journal_title：Neuroreport

authors： Harada M,Fuse A,Tanaka Y

更新日期：1997-03-03 00:00:00

abstract：:We used two developmental transcription factors, x-Eomes (T-box family) and x-Lhx5 (LIM-homeodomain family), to follow the origin and development of the olfactory bulbs in Xenopus. During embryonic and larval development, x-Eomes and x-Lhx5 were expressed in highly similar patterns, in the lateral and latero-ventral w...

journal_title：Neuroreport

authors： Moreno N,Bachy I,Rétaux S,González A

更新日期：2003-12-19 00:00:00

abstract：:Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patien...

journal_title：Neuroreport

authors： Sun Z,Wang F,Cui L,Breeze J,Du X,Wang X,Cong Z,Zhang H,Li B,Hong N,Zhang D

更新日期：2003-10-06 00:00:00

abstract：:Mitochondrial dysfunction and oxidative stress are implicated in the pathological changes observed in the diabetic central nervous system. In this study, using the streptozotocin-induced diabetic rat model we document for the first time the over-expression of a mitochondrial specific stress protein (chaperonin 60) in ...

journal_title：Neuroreport

authors： Yuan J,Young BJ,Martinus RD

更新日期：2006-02-27 00:00:00

abstract：:Melatonin, a hormone from the pineal gland, was tested for its anticonvulsant effects in male gerbils. Daily administration of melatonin (25 micrograms injection-1, s.c.) for ten weeks reduced the number and severity of seizures (total convulsion score: 7.67 +/- 1.83 in controls vs 2.47 +/- 0.90 in melatonin-injected ...

journal_title：Neuroreport

authors： Champney TH,Champney JA

更新日期：1992-12-01 00:00:00

abstract：:Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...

journal_title：Neuroreport

authors： Barmashenko G,Eysel UT,Mittmann T

更新日期：2001-10-08 00:00:00

abstract：:Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confi...

journal_title：Neuroreport

authors： Burazin TC,Gundlach AL

更新日期：1995-10-02 00:00:00

abstract：:We validated and used a high-performance liquid chromatography procedure for the determination of four different amino acid neurotransmitters in cultured rat neurons and used culture medium. Samples were derivatized using 2,4-dinitrofluorobenzene and the amino acids were separated on a C18 column. The method yielded g...

journal_title：Neuroreport

authors： Zhang F,Ma XL,Wang YX,Su RR,He C,Tian K,Liu YQ

更新日期：2016-05-04 00:00:00

abstract：:Birds are capable of dexterous sensory-motor activities such as tool use. Reaching is a crucial component of tool use and is a vision-guided behavior in primates, in which arm movement is monitored online in a stable visual frame. However, vision-guided reaching in primates is enabled by anatomical separation of the h...

journal_title：Neuroreport

authors： Kanai M,Matsui H,Watanabe S,Izawa E

更新日期：2014-09-10 00:00:00

abstract：:In the adult brain, neural proliferation is almost absent and neurons are generally not renewed. By contrast, in the olfactory organ, olfactory neurons are produced continuously throughout life. To investigate whether specific cell cycle inhibitors are involved in the control of neural quiescence in adulthood, we comp...

journal_title：Neuroreport

authors： Legrier ME,Ducray A,Propper A,Kastner A

更新日期：2001-10-08 00:00:00

abstract：:Rats with an experimental painful peripheral neuropathy (the chronic injury (CCI) model) display heatevoked hyperalgesia. There is now considerable evidence that nitric oxide (NO) and nitric oxide synthase are involved in the development of hyperalgesia in acute inflammatory pain states. The mechanisms responsible for...

journal_title：Neuroreport

authors： Tal M

更新日期：1996-05-31 00:00:00

abstract：:Activated NF-kappaB contributes to cerebral infarction by triggering a neuro-inflammatory response. Rats subjected to 90min middle cerebral artery occlusion developed a cortical infarct of 20+/-4% of hemispheric volume (n = 8). Treatment with the proteasome inhibitor CVT-634 resulted in a significantly smaller infarct...

journal_title：Neuroreport

authors： Buchan AM,Li H,Blackburn B

更新日期：2000-02-07 00:00:00

abstract：:The hypothesis that reactive free radical species (ROS) may contribute to the pathogenesis of Duchenne muscular dystrophy (DMD) has been suggested previously, but experimental data obtained in support of the above have to date proved inconclusive. The recent discovery that nitric oxide synthase (required for muscle re...

journal_title：Neuroreport

authors： Haycock JW,MacNeil S,Jones P,Harris JB,Mantle D

更新日期：1996-12-20 00:00:00

abstract：:Endothelin-1 (ET-1) is recognized as being involved in the pathophysiology of cerebrovascular diseases. Using organ culture as a model for possible pathological changes we studied changes in ET(A) and ETB receptor function using a sensitive in vitro method. We observed an up-regulation of the ET(B) receptor and an ama...

journal_title：Neuroreport

authors： Hansen-Schwartz J,Edvinsson L

更新日期：2000-02-28 00:00:00

abstract：:Astrocytes induce blood-brain barrier (BBB) properties in brain endothelial cells (EC)*O(2)*, generated in blood and EC, opens the BBB. Hence, high activity of superoxide dismutase (SOD) is a prerequisite for normal BBB function. Therefore, the influence of rat astrocytes on the expression of manganese (Mn)SOD in rat ...

journal_title：Neuroreport

authors： Schroeter ML,Müller S,Lindenau J,Wiesner B,Hanisch UK,Wolf G,Blasig IE

更新日期：2001-08-08 00:00:00

abstract：:To test the effect of nitric oxide synthase (NOS) blockade on the ventilatory responses to carotid body chemoreceptor stimulation in freely behaving animals, chronically instrumented adult Sprague-Dawley rats received increasing intravenous doses of sodium cyanide (NaCN; 0-300 micrograms kg-1) before and after i.v. ad...

journal_title：Neuroreport

authors： Gozal D,Gozal E,Gozal YM,Torres JE

更新日期：1996-04-26 00:00:00

abstract：:Optical imaging of rat barrel cortex has provided detailed spatio-temporal maps of functional cortical architecture. We describe an event-related procedure (ERP) for optical imaging based on selective signal averaging as reported by Burock et al., using an anti-correlative pseudo-random event sequence. The sequence us...

journal_title：Neuroreport

authors： Martindale J,Berwick J,Johnston D,Jones M,Zheng Y,Coffey P,Paley M,Mayhew J

更新日期：2000-07-14 00:00:00

abstract：:We inserted microelectrodes in eye movement-evoking cortices (EMECs) of cats and examined whether neurones in the EMECs received sensory input from guide signals and fired prior to saccades. The five EMECs were the medial wall of the hemisphere under the cruciate sulcus, the medical and lateral bank of the presylvian ...

journal_title：Neuroreport

authors： Tamai Y,Kimura A

更新日期：1996-10-02 00:00:00

abstract：:In a previous event-related fMRI study, we showed that the left occipitotemporal cortex was specifically involved in the abstract categorization of visually presented alphabetic symbols. Here, we duplicate the fMRI study by measuring visual event-related potentials to verify whether the left posterior cortex supports ...

journal_title：Neuroreport

authors： Gros H,Doyon B,Rioual K,Celsis P

更新日期：2002-06-12 00:00:00

abstract：:High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocyst...

journal_title：Neuroreport

authors： Lee YS,Han DH,Jeon CM,Lyoo IK,Na C,Chae SL,Cho SC

更新日期：2006-05-15 00:00:00

abstract：:Intra-ischemic hypothermia is known to protect neurons against ischemic injury. Microglial cells have been shown to become activated following ischemia and are speculated to play significant roles in the evolution of ischemic neuronal injury. In this study, we examined the effect of intra-ischemic hypothermia on the m...

journal_title：Neuroreport

authors： Kumar K,Evans AT

更新日期：1997-03-03 00:00:00

abstract：:Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly 10% of the population. At present there is no cure for this disorder but gene therapy has been suggested as a potentially effective method for clinical treatment in the future. Thus we investigated the effectiveness of adenovira...

journal_title：Neuroreport

authors： Li Duan M,Bordet T,Mezzina M,Kahn A,Ulfendahl M

更新日期：2002-07-19 00:00:00

abstract：:The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distribute...

journal_title：Neuroreport

authors： Nickell WT,Norman AB,Wyatt LM,Shipley MT

更新日期：1991-01-01 00:00:00

abstract：:Establishing the computational rules and neural substrates of brightness coding is a topic of both historical and contemporary interest. Two major classes of explanations for brightness illusions, such as brightness contrast, can be traced to Hering and Helmholtz. Hering's legacy is a low-level account in which bright...

journal_title：Neuroreport

authors： McCourt ME,Foxe JJ

更新日期：2004-01-19 00:00:00

abstract：:The taste reactivity test was used to evaluate the ability of motion sickness to produce conditioned rejection reactions, a putative measure of nausea in rats. Following three conditioning trials, rats displayed conditioned rejection reactions during an intraoral infusion of a rotation-paired saccharin solution. This ...

journal_title：Neuroreport

authors： Cordick N,Parker LA,Ossenkopp KP

更新日期：1999-05-14 00:00:00

abstract：:Short-term exposure of primary cultures of cerebellar granule cells from neonatal rat brain to high concentrations of glutamate results in neuronal degeneration. We found that glutamate, before causing neuronal degeneration, induced a significant increase of Tau protein immunostaining. Time-course experiments revealed...

journal_title：Neuroreport

authors： Pizzi M,Valerio A,Ribola M,Spano PF,Memo M

更新日期：1993-06-01 00:00:00

abstract：:Retinal light exposure induces several immediate-early genes in the hypothalamic suprachiasmatic nucleus (SCN), which contains the major circadian pacemaker of mammals. Clock-controlled and light-induced genes expressed in the SCN such as c- and contain upstream regulatory elements similar to those of the major immedi...

journal_title：Neuroreport

authors： Sigworth LA,Liao L,Chandler TR,Geusz ME

更新日期：2003-03-03 00:00:00