Abstract:
:Short-term exposure of primary cultures of cerebellar granule cells from neonatal rat brain to high concentrations of glutamate results in neuronal degeneration. We found that glutamate, before causing neuronal degeneration, induced a significant increase of Tau protein immunostaining. Time-course experiments revealed the increase ot Tau immunoreactivity to be maximal 2 h after the glutamate pulse. To investigate the possible role of newly synthesized Tau protein in the neurotoxic process activated by glutamate, cerebellar granule cells were preincubated with a specific Tau antisense oligonucleotide. This treatment resulted in (i) an inhibition of the glutamate-induced increase of Tau immunoreactivity and (ii) a decrease in the sensitivity of the neurones to neurotoxic concentrations of glutamate. These data indicate that new synthesis of the cytoskeleton-associated Tau protein is a crucial step in the cascade of events promoted by glutamate and leading to neurodegeneration.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Pizzi M,Valerio A,Ribola M,Spano PF,Memo Mdoi
10.1097/00001756-199306000-00057subject
Has Abstractpub_date
1993-06-01 00:00:00pages
823-6issue
6eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
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