Abstract:
:The parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridine (MPP+) acts through inhibition of complex I of the electron transport chain. Recent evidence suggests that it may also act through inhibition of 2-ketoglutarate dehydrogenase complex (KDHC). We confirmed this observation in isolated rat liver mitochondria but found that this inhibition is prevented by preincubation with the radical quencher, cysteine (Cys). KDHC is also inhibited by the NO generator S-nitroso-N-acetyl-penicillamine (SNAP) and this inhibition is similarly blocked by cysteine. MPP+ may inhibit KDHC secondary through a radical-mediated event rather than through direct interaction with KDHC.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Joffe GT,Parks JK,Parker WD Jrdoi
10.1097/00001756-199808240-00018subject
Has Abstractpub_date
1998-08-24 00:00:00pages
2781-3issue
12eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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