Abstract:
:Capsaicin in the adult animal causes antinociception due to the massive release of neurotransmitters, including substance P (SP), from primary afferent C-fibers. The results of the present study indicate that capsaicin-induced antinociception in the adult is sensitive to inhibition by dizocilpine (MK-801). The failure of a high dose (10 nmoles) of (+-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) to mimic the effect of MK-801 (1 nmole) on antinociception induced by 0.8 micrograms of capsaicin suggests that the inhibition by MK-801 is mediated by a phencyclidine (PCP) site but is not associated with NMDA activity. The inability of haloperidol (1 nmole) to affect the actions of capsaicin argues against an interaction with sigma sites. Behavioral sensitization to intrathecally administered kainic acid (KA) has been proposed to reflect similar neuronal activity to that underlying pain transmission. KA sensitization is inhibited by pretreatment with capsaicin (0.8 microgram) or SP(1-7) (10 nmoles) and the influence of MK-801, CPP and haloperidol on these inhibitory effects of capsaicin and SP(1-7) were identical to those on capsaicin-induced antinociception. These data are consistent with the hypothesis that the antinociceptive effect of capsaicin in the adult is similar to that of the N-terminus of SP, both of which involve a pathway sensitive to MK-801 but not mediated by NMDA-type activity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Sun X,Larson AAsubject
Has Abstractpub_date
1993-09-03 00:00:00pages
1147-50issue
10eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Although beta-amyloid precursor protein (APP) has been suggested to play a role in neuronal survival and plasticity, the mRNA expression of APP has not been studied in terms of neuronal activity. In cultures of mouse cerebellar granule cells, we found that the levels of APP mRNA increased when a high concentration of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000127140.54853.04
更新日期:2004-06-07 00:00:00
abstract::Electroencephalography (EEG) and gaze data have traditionally been separated in neurocognitive studies because of the artefacts that even small controlled eye movements produce. Study of gaze control in a visual tracking task provides information about an individual's prospective control. By including gaze events in t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000020
更新日期:2013-12-04 00:00:00
abstract::Melatonin, a hormone from the pineal gland, was tested for its anticonvulsant effects in male gerbils. Daily administration of melatonin (25 micrograms injection-1, s.c.) for ten weeks reduced the number and severity of seizures (total convulsion score: 7.67 +/- 1.83 in controls vs 2.47 +/- 0.90 in melatonin-injected ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199212000-00031
更新日期:1992-12-01 00:00:00
abstract::Regional variation in the distribution of SP and NFT within the brain is well documented. Consideration of such variation is potentially of help in formulating models of disease progression. Several models propose that pathological changes in Alzheimer's disease (AD) progress in a step-wise fashion along neuronally co...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199912160-00012
更新日期:1999-12-16 00:00:00
abstract::In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse model of Huntington's disease (HD). Using BrdU labelling for dividing cells at two different time points (5 and 20 weeks) in transgenic and wi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404090-00014
更新日期:2004-04-09 00:00:00
abstract::Flurothyl kindling initiates a time-dependent process that results in a facilitated propagation from the forebrain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00013
更新日期:1998-11-16 00:00:00
abstract::Synaptic or 'hard wired' neurotransmission in the brain, subject to modulation by a class of substances called modulators, has been the dominant model of brain function. However, increasing evidence for alternate non-synaptic neurotransmission mechanisms is forcing consideration of a more inclusive model. Evidence is ...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-199304000-00001
更新日期:1993-04-01 00:00:00
abstract::Sensory funneling of liminal multiple-point air-puff stimulation on the skin was evaluated by measuring somatosensory evoked potentials (SEPs), reaction time (RT) and subjective detection threshold. Single-point air-puffs at the threshold intensity, and 2-point and 3-point air-puffs (10 mm apart) of the same intensity...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199910190-00014
更新日期:1999-10-19 00:00:00
abstract::We investigated the influence of noise on brain responses to spoken sentences in MEG. Sixteen subjects had to listen to acoustically presented sentences and judge their syntactic correctness. Sentences were either presented on a silent background or with noise. Noise had differential effects on early auditory and synt...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200002070-00001
更新日期:2000-02-07 00:00:00
abstract::A tritiated specific and highly potent 5-HT4 antagonist: [3H]-GR113808 was used to label specific binding sites in human brain and for comparison in guinea-pig brain. [3H]-GR113808 association and dissociation were rapid, the binding was saturable and displaced by various serotoninergic agents with an affinity corresp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199309000-00007
更新日期:1993-09-10 00:00:00
abstract::It has been reported that intracerebroventricular (i.c.v.) injection of nociception/orphanin FQ (OFQ) can antagonize morphine analgesia, whereas i.c.v. OFQ antibody can reverse morphine tolerance. Nocistatin (NST) is a recently characterized neuropeptide possessing an antagonizing effect on OFQ. Here we examine whethe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00054
更新日期:2001-06-13 00:00:00
abstract::Experiments using chimeric stimuli have shown that the right hemisphere is more influential in processing facial information. Here, again, we found clear evidence that study participants used the information from the left side of the face to inform their gender decisions when chimeric male/female, female/male stimuli ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200512190-00004
更新日期:2005-12-19 00:00:00
abstract::The distribution and modulation of neural cell adhesion molecule polysialylation state (NCAM PSA) and the consequence of antisense inactivation of the Kv1.1 potassium channel was investigated following avoidance learning in mice. PSA immunoreactivity was most notable on cells at the inner denate border and in cortical...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00008
更新日期:1998-08-24 00:00:00
abstract::Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199612200-00010
更新日期:1996-12-20 00:00:00
abstract::Adeno-associated virus type2 (AAV-2) binds to heparan-sulfate proteoglycans on the cell surface. In vivo, attachment of viral particles to cells adjacent to the injection tract limits the distribution of AAV-2 when infused into the CNS parenchyma and heparin co-infusion might decrease the binding of AAV-2 particles to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00037
更新日期:2001-07-03 00:00:00
abstract::In mammals, the thalamic intergeniculate leaflet (IGL) conveys behavioral (non-photic) phase-resetting information to the circadian clock of the suprachiasmatic nucleus. Here we report a 24 h fluctuation in in vivo serotonin release in the hamster IGL region, peaking at night. Novel wheel exposure at midday, a stimulu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200401190-00021
更新日期:2004-01-19 00:00:00
abstract::The purpose of this study was to examine motor imagery ability in patients with peripheral nerve disorder using the hand mental rotation task. Five patients with left total avulsion brachial plexus palsy (BPP) and 16 healthy age-matched adults participated in this study. The mean±SD time from the injury was 103.6±49.7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001229
更新日期:2019-04-10 00:00:00
abstract::SCN1A gene mutations are associated with epilepsy and neurodevelopmental disorders. This study aimed to explore the genotype and phenotype spectrum of SCN1A gene related epilepsy. Epileptic patients who were treated in the Children's Hospital of Chongqing Medical University from January 2015 to July 2018 and identifie...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001259
更新日期:2019-06-12 00:00:00
abstract::The present study investigated the effect of lexical competition on the time course of spoken word recognition in Mandarin Chinese using a unimodal auditory priming paradigm. Two kinds of competitive environments were designed. In one session (session 1), only the unrelated and the identical primes were presented befo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000492
更新日期:2016-01-20 00:00:00
abstract::Bulbospinal C1 neurons are sympathoexcitatory and excited by substance P. However the substance P receptor (NK1 receptor), has been reported to be absent from the somata of C1 neurons. In this study, using double and triple labelling immunofluorescence and retrograde tracing, we provide evidence that the NK1 receptor ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112040-00012
更新日期:2001-12-04 00:00:00
abstract::There has been intense interest in determining how the visual brain processes the outside world, and in identifying the neuroanatomical correlates of the ability to create art. Comparing art production before and after illness onset permits some speculation on the function of selective brain regions affected by the ne...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-200404290-00001
更新日期:2004-04-29 00:00:00
abstract::We previously reported that withdrawal from chronic cocaine produces supersensitivity of serotonin 2A receptors. We report here the minimum cocaine exposure necessary to produce withdrawal-associated increases in serotonin 2A receptor signaling in the frontal cortex. Rats withdrawn from cocaine treatments of 1, 3 or 7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000246324.43567.55
更新日期:2007-01-08 00:00:00
abstract::The effect of Co-dergocrine (Hydergine) on acetylcholine (ACh) release in the striatum and hippocampus has been studied by means of brain microdialysis and compared to the effect of SKF 38393 and of LY 171555 selective D1 and D2 dopamine (DA) receptor agonists, respectively. Co-dergocrine (1 and 5 mg kg-1 i.p.) as wel...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199402000-00003
更新日期:1994-02-24 00:00:00
abstract::This study aimed to evaluate the potential of bone marrow stromal cells for treatment of inner ear diseases. Autologous marrow cells labeled with Dil were implanted into the inner ear of five gentamicin-treated chinchillas. Histological analysis 3 weeks later revealed robust survival of grafted marrow cells in multipl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200401190-00001
更新日期:2004-01-19 00:00:00
abstract::Extracellular recordings were used to determine the effects of cannabinoids on the activity of dopamine neurons within the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC). Systemic administration of the natural psychoactive cannabinoid delta 9-tetrahydrocannabinol (delta 9-THC) and the synthetic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00014
更新日期:1997-02-10 00:00:00
abstract::In situ hybridization has demonstrated mRNA for olfactory receptors (OR) in the axon terminals of olfactory receptor neurons. Neurons that express the same OR appear to send their axons to two stereotyped glomeruli in the olfactory bulb (OB). Based on these observations, we tested the feasibility of using RT-PCR to is...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00032
更新日期:1998-11-16 00:00:00
abstract::We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00023
更新日期:1996-05-17 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) and adrenomedullin are structurally similar neuropeptides acting as potent vasodilators of blood pressure and mediator of inflammation in skin. Revealing the expression pattern of their common receptor-Calcitonin gene-related peptide receptor (Calcrl) in their targeted cells is i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001497
更新日期:2020-08-05 00:00:00
abstract::Functional neuroimaging studies of handedness have traditionally focused on exploring regionally activated discrepancies, yet little is known regarding the effect of handedness on functional connections of brain regions. Here, we reported the relationship between cerebellar functional connectivity patterns and handedn...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000192737.92911.a4
更新日期:2006-01-23 00:00:00
abstract::The ability to attribute mental states to others ('theory of mind') pervades normal social interaction and is impaired in autistic individuals. In a previous positron emission tomography scan study of normal volunteers, performing a 'theory of mind' task was associated with activity in left medial prefrontal cortex. W...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199612200-00040
更新日期:1996-12-20 00:00:00