Kv1.1 channel antisense attenuates learning and modulation of dentate polysialylated NCAM.

Abstract:

:The distribution and modulation of neural cell adhesion molecule polysialylation state (NCAM PSA) and the consequence of antisense inactivation of the Kv1.1 potassium channel was investigated following avoidance learning in mice. PSA immunoreactivity was most notable on cells at the inner denate border and in cortical layer II. Task acquisition resulted in a significant 30% transient increase in the frequency of dentate polysialylated neurons at the 12 h post-training time. In contrast, animals pretreated with the Kv1.1 antisense oligonucleotide exhibited both attenuated recall avoidance latencies and polysialylated cell frequency. As Kv1.1 is enriched on the dendrites of these granule-like cells, the attenuated polysialylation response is considered secondary to NCAM-mediated events during their transient synapse production in the 6-8 h post-training period.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Gratacós E,Ghelardini C,Gherardini LM,Galeotti N,Murphy KJ,Bartolini A,Regan CM

doi

10.1097/00001756-199808240-00008

subject

Has Abstract

pub_date

1998-08-24 00:00:00

pages

2727-31

issue

12

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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