Abstract:
:The distribution and modulation of neural cell adhesion molecule polysialylation state (NCAM PSA) and the consequence of antisense inactivation of the Kv1.1 potassium channel was investigated following avoidance learning in mice. PSA immunoreactivity was most notable on cells at the inner denate border and in cortical layer II. Task acquisition resulted in a significant 30% transient increase in the frequency of dentate polysialylated neurons at the 12 h post-training time. In contrast, animals pretreated with the Kv1.1 antisense oligonucleotide exhibited both attenuated recall avoidance latencies and polysialylated cell frequency. As Kv1.1 is enriched on the dendrites of these granule-like cells, the attenuated polysialylation response is considered secondary to NCAM-mediated events during their transient synapse production in the 6-8 h post-training period.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gratacós E,Ghelardini C,Gherardini LM,Galeotti N,Murphy KJ,Bartolini A,Regan CMdoi
10.1097/00001756-199808240-00008subject
Has Abstractpub_date
1998-08-24 00:00:00pages
2727-31issue
12eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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