Abstract:
:TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highest level on postnatal day 3 (P3) and then dramatically decreased by P15. Low levels persisted (adulthood, P45 to 67) with mean mRNA abundance after P15 less than 25% of P3 levels. DFNA5 mRNA expression was constant throughout these time points. These results imply that TECTA is transcribed at a particularly high level during tectorial membrane morphogenesis. In contrast, DFNA5 is present in both the developing and mature cochlea.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Maeda Y,Fukushima K,Kasai N,Maeta M,Nishizaki Kdoi
10.1097/00001756-200110290-00016subject
Has Abstractpub_date
2001-10-29 00:00:00pages
3223-6issue
15eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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