LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels.

Abstract:

:It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced by this same stimulus. Although the amplitude of LTP is similar to that observed in slices from 30-day-old rats, LTP in slices from mature rats is not inhibited by MK-801 but is blocked by nifedipine. These results suggest that factors contributing to LTP in slices from mature rats require careful consideration under different experimental paradigms.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Izumi Y,Zorumski CF

doi

10.1097/00001756-199811160-00022

subject

Has Abstract

pub_date

1998-11-16 00:00:00

pages

3689-91

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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