Superinduction of leptin mRNA in mouse hypothalamic neurons.

abstract：:The whole-cell patch clamp technique was used to investigate the actions of the opioid agonist U50488H on Ca2+ and K+ currents in differentiated NG108-15 cells. U50488H (5-50 microM) caused a concentration-dependent, reversible inhibition of high voltage-activated Ca2+ currents which persisted in the presence of nifed...

journal_title：Neuroreport

authors： Carpenter E,Gent JP,Peers C

更新日期：1996-07-29 00:00:00

abstract：:Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effe...

journal_title：Neuroreport

authors： Engber TM,Papa SM,Boldry RC,Chase TN

更新日期：1994-12-20 00:00:00

abstract：:High concentrations of local anesthetics are neurotoxic, but the mechanism for this neurotoxicity is obscure. Here, we report increased concentrations of glutamate in the cerebrospinal fluid after intrathecal injections of high concentrations of tetracaine (a local anesthetic). The peak concentrations of glutamate aft...

journal_title：Neuroreport

authors： Ohtake K,Matsumoto M,Wakamatsu H,Kawai K,Nakakimura K,Sakabe T

更新日期：2000-04-07 00:00:00

abstract：:Dopamine plays important functional roles in the vertebrate retina. Here we show that functional D2 dopamine receptors are present on mammalian retinal Müller (glial) cells. Using an antiserum directed to two oligopeptides predicted from rat D2 receptor DNA, patchy label was demonstrated immunocytochemically on virtua...

journal_title：Neuroreport

authors： Biedermann B,Fröhlich E,Grosche J,Wagner HJ,Reichenbach A

更新日期：1995-03-07 00:00:00

abstract：:In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...

journal_title：Neuroreport

authors： Comelli MC,Seren MS,Guidolin D,Manev RM,Favaron M,Rimland JM,Canella R,Negro A,Manev H

更新日期：1992-06-01 00:00:00

abstract：:The amount of backward walking induced in mice by co-administration of clenbuterol, a beta-adrenoceptor agonist and putative antidepressant, and the benzodiazepine chlordiazepoxide was plotted as a three-dimensional surface, using modified Uniras software. The surface was compared with the theoretical surface to be ex...

journal_title：Neuroreport

authors： Hughes MJ,Sykes EA,Steinberg H

更新日期：1992-07-01 00:00:00

abstract：:Following brain injury astrocytes swell acutely and proliferate thereafter. To investigate the direct relationship between swelling and proliferation, cultured astroglial cells were exposed to 60 mM K+ ion or hypo-osmolar (205 mOsm) electrolyte solution for 1 h to cause transient swelling. Proliferation was assessed b...

journal_title：Neuroreport

authors： Del Bigio MR,Omara F,Fedoroff S

更新日期：1994-01-31 00:00:00

abstract：:Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...

journal_title：Neuroreport

authors： Brigman JL,Daut RA,Saksida L,Bussey TJ,Nakazawa K,Holmes A

更新日期：2015-06-17 00:00:00

abstract：:There is no unifying hypothesis to account for the anatomical distribution of neuropathology, the involvement of beta-amyloid precursor protein (beta APP) and the role of increasing age in triggering the Alzheimer disease process. We report here that layer II pre-alpha neurones in transentorhinal and entorhinal cortex...

journal_title：Neuroreport

authors： Roberts GW,Nash M,Ince PG,Royston MC,Gentleman SM

更新日期：1993-01-01 00:00:00

abstract：:Adenosine has an anticonvulsant effect in various models of epilepsy. This effect appears to be mediated through the activation of adenosine A1 receptors (A1Rs). We immunohistochemically investigated the changes of A1Rs expression in kainate-treated and hippocampus-kindled rats as chronic models of epilepsy. In the no...

journal_title：Neuroreport

authors： Ochiishi T,Takita M,Ikemoto M,Nakata H,Suzuki SS

更新日期：1999-11-26 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained unclear. In this study, we investigated the roles of SIRT2 in...

journal_title：Neuroreport

authors： Nie H,Hong Y,Lu X,Zhang J,Chen H,Li Y,Ma Y,Ying W

更新日期：2014-08-06 00:00:00

abstract：:Dopamine (DA) deficiency in Parkinson's disease is commonly treated with L-dihydroxyphenylalanine (L-dopa), the amino acid precursor to DA. L-dopa is neurotoxic in vitro and impairs survival of metabolically stressed neurons in vivo. We examined with microdialysis of substantia nigra in awake rats the local production...

journal_title：Neuroreport

authors： Smith TS,Parker WD Jr,Bennett JP Jr

更新日期：1994-04-14 00:00:00

abstract：:This study was performed to test the hypothesis that diminution in the preovulatory luteinizing hormone (LH) surge in middle-aged (MA) rats may be related to altered activity in nitric oxide (NO)ergic neurons. To begin to test the hypothesis, gene expression of hypothalamic NO synthase (NOS), the enzyme that catalyzes...

journal_title：Neuroreport

authors： Sahu A

更新日期：1998-12-21 00:00:00

abstract：:The effect of neonatal axotomy on the maturation of motoneurone somadendritic morphology was studied in identified motoneurones innervating the ankle dorsiflexor muscles tibialis anterior (TA) and extensor digitorum longus (EDL) of the rat by intracellular injection of Lucifer Yellow and confocal microscopy. At birth,...

journal_title：Neuroreport

authors： Dekkers J,Navarrete R

更新日期：1998-05-11 00:00:00

abstract：:To test the hypothesis that correlated neuronal activity serves as the neuronal code for visual feature binding, we applied information theory techniques to multiunit activity recorded from pairs of V1 recording sites in anaesthetised cats while presenting either single or separate bar stimuli. We quantified the roles...

journal_title：Neuroreport

authors： Golledge HD,Panzeri S,Zheng F,Pola G,Scannell JW,Giannikopoulos DV,Mason RJ,Tovée MJ,Young MP

更新日期：2003-05-23 00:00:00

abstract：:The neuroprotective effects of netrin-1 after spinal cord injury and its specific molecular mechanisms have not been elucidated. In our study, Western blot, transferase UTP nick end labeling staining and immunofluorescence staining first showed that netrin-1 significantly decreased the expression levels of caspase-3, ...

journal_title：Neuroreport

authors： Gao K,Niu J,Dang X

更新日期：2020-05-07 00:00:00

abstract：:Aminoglycoside ototoxicity is a well-documented process via several pathophysiological pathways. The protective role of cochlear dopamine, released from the lateral olivocochlear efferents, was implicated previously in case of ischemia or acoustic trauma, as it postsynaptically inhibits the effect of excessively relea...

journal_title：Neuroreport

authors： Gáborján A,Halmos G,Répássy G,Vizi ES

更新日期：2001-10-29 00:00:00

abstract：:Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells v...

journal_title：Neuroreport

authors： Persico AM,Baldi A,Dell'Acqua ML,Moessner R,Murphy DL,Lesch KP,Keller F

更新日期：2003-03-03 00:00:00

abstract：:Cyclooxygenase (COX)-2 is constitutively expressed in the superficial dorsal horn of the spinal cord, but its role in the spinal cord is still unclear. We examined the effect of intrathecally administered NS398, a selective COX-2 inhibitor and indomethacin, an non-selective COX-1 and COX-2 inhibitor, on the developmen...

journal_title：Neuroreport

authors： Yamamoto T,Sakashita Y

更新日期：1998-12-01 00:00:00

abstract：:Predicting neuron death or survival after axonal injury is important in neurotrauma research. We now used in vivo confocal neuroimaging microscopy to repeatedly visualize retinal ganglion cells after optic nerve crush and studied their morphological alterations and ultimate fate. An intracollicular injection of a retr...

journal_title：Neuroreport

authors： Rousseau V,Engelmann R,Sabel BA

更新日期：1999-11-08 00:00:00

abstract：:To confirm neural plasticity of the mouse hippocampo-prefrontal cortex (PFC) pathway, paired-pulse facilitation (PPF) and long-term potentiation (LTP) induction were determined in the pathway. In addition, we tested whether the plasticity differs in projections of the pathway from the dorsal (upper) and ventral (lower...

journal_title：Neuroreport

authors： Izaki Y,Takita M,Nomura M

更新日期：2001-05-08 00:00:00

abstract：:The aim of this study was to determine the changes of the nociceptive thresholds in response to an acute mechanical stimulus (paw pressure) in magnesium (Mg)-deficient rats, and the involvement of the NMDA receptor in these changes. Changes in vocalization thresholds was determined after 7 days of feeding with a Mg-de...

journal_title：Neuroreport

authors： Dubray C,Alloui A,Bardin L,Rock E,Mazur A,Rayssiguier Y,Eschalier A,Lavarenne J

更新日期：1997-04-14 00:00:00

abstract：:Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...

journal_title：Neuroreport

authors： Priori A,Berardelli A,Rona S,Accornero N,Manfredi M

更新日期：1998-07-13 00:00:00

abstract：:The effects of a pharmacological blockade of the periaqueductal grey of the midbrain (PAG) on the elicitability of vocal fold movements from the facial motor cortex on the one hand and the anterior cingulate cortex and dorsomedial hypothalamus on the other were studied in the squirrel monkey. PAG blockade abolished vo...

journal_title：Neuroreport

authors： Jürgens U,Zwirner P

更新日期：1996-11-25 00:00:00

abstract：:Sleep disorders increase with ageing. The serotonergic system has been linked with sleep regulation. In fatal familial insomnia, a prion disease with insomnia as one major clinical feature, we recently observed a disturbance in the serotonergic system as likely substrate of typical symptoms. Using immunohistochemistry...

journal_title：Neuroreport

authors： Klöppel S,Kovacs GG,Voigtländer T,Wanschitz J,Flicker H,Hainfellner JA,Guentchev M,Budka H

更新日期：2001-03-26 00:00:00

abstract：:Using NADPH-diaphorase (NADPH-d) staining as a marker for the enzyme nitric oxide synthase (NOS) we investigated the possible sites of nitric oxide (NO) synthesis in the olfactory pathways of an insect brain. Staining of frozen sections revealed NADPH-d activity in neurones and in glial cells. A cluster of intensely s...

journal_title：Neuroreport

authors： Bicker G,Hähnlein I

更新日期：1995-01-26 00:00:00

abstract：:Because of anecdotal reports in which ibogaine eliminates opioid withdrawal symptoms in humans, we studied this phenomenon in the rat model. Ibogaine (5, 10, 20 and 40 mg kg-1, s.c.) was administered 15 min before naloxone (0.5 mg kg-1, s.c.) in morphine dependent rats (3 days after the s.c. implantation of a 75 mg mo...

journal_title：Neuroreport

authors： Sharpe LG,Jaffe JH

更新日期：1990-09-01 00:00:00

abstract：:When examining a buying process, changes in human brain signals and their event-related potential (ERP) components can be considered a reflection of the consumers' emotions. In this experiment, participants were shown 12 products and related services that were available for purchase. After recording ERP components, we...

journal_title：Neuroreport

authors： Zhao M,Wang J,Han W

更新日期：2015-12-02 00:00:00

abstract：:The temporal lobe regions involved in memory retrieval were examined using fMRI. During an associative recognition test, participants made memory judgments about the study color of previously presented drawings of objects, and during item recognition tests they made old/new judgments about previously studied objects o...

journal_title：Neuroreport

authors： Yonelinas AP,Hopfinger JB,Buonocore MH,Kroll NE,Baynes K

更新日期：2001-02-12 00:00:00

abstract：:The effects of high frequency repetitive transcranial magnetic stimulation on sensory perception and the pain tolerance thresholds were investigated applying both motor cortex stimulation and medial frontal cortex stimulation in normal study participants. Both the sensory perception and pain tolerance thresholds were ...

journal_title：Neuroreport

authors： Yoo WK,Kim YH,Doh WS,Lee JH,Jung KI,Park DS,Park ES

更新日期：2006-02-06 00:00:00