Abstract:
:Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effect of NMDA receptor blockade on the development of alterations in the motor response to chronic levodopa was evaluated in hemiparkinsonian rats. Repeated levodopa administration decreased rotational behavior induced by a D1 dopamine receptor agonist, increased D2 agonist-induced rotation and progressively reduced the duration of the motor response to levodopa itself. Acute pretreatment with the noncompetitive NMDA antagonist MK-801 completely reversed all these changes. These findings suggest that NMDA receptor-mediated mechanisms contribute to the behavioral plasticity associated with chronic levodopa treatment and that NMDA antagonists might be effective in reversing the motor response complications of the long-term levodopa therapy.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Engber TM,Papa SM,Boldry RC,Chase TNdoi
10.1097/00001756-199412000-00045subject
Has Abstractpub_date
1994-12-20 00:00:00pages
2586-8issue
18eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Human somatosensory evoked potentials (SEP) contain high-frequency (600 Hz) wavelet bursts possibly reflecting repetitive population spikes in thalamocortical axons and/or postsynaptic responses. To dissociate thalamic and cortical burst components the recovery of intrathalamic SEP (derived from electrodes implanted f...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200004270-00030
更新日期:2000-04-27 00:00:00
abstract::Proteins of the postsynaptic density are implicated in mechanisms of synaptic plasticity. We examined involvement of PSD95 and alphaCaMkII in learning-dependent plastic changes of representational maps in somatosensory cortex of mice. The barrel cortex of mice was examined following a 3 day long classical conditioning...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00030
更新日期:2001-09-17 00:00:00
abstract::The putative memory mechanism known as long-term potentiation (LTP) has been described in both NMDA-dependent and non-NMDA-dependent forms. The aim of the present study was to determine which of these forms described the LTP generated between perirhinal cortex (PRC) and hippocampus, two structures which have previousl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199605170-00003
更新日期:1996-05-17 00:00:00
abstract::While effects of attention on late and middle latency components of the evoked potential have been demonstrated, similar effects on brain stem evoked potentials--in particular on the human frequency-following potential (FFP)--are controversial. The FFP is a response to tone bursts in the frequency range of human langu...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199408150-00017
更新日期:1994-08-15 00:00:00
abstract::This study examined the long-term effects of the antidepressant escitalopram on rat serotonin (5-HT) neuronal activity and hippocampal neuroplasticity. In the dorsal raphe nucleus, a 2-week treatment with escitalopram (10 mg/kg/day, subcutaneous) did not modify the firing activity of 5-HT neurons, whereas a cotreatmen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f04047
更新日期:2007-10-08 00:00:00
abstract::To compare the maximum Hoffmann reflex (H-reflex) and the maximum M-wave (H : M) ratio of the H-reflex in men and women when all participants showed similar saliva levels of estradiol and progesterone. This is a cohort design study involving healthy men and women with a mean age of 22.4±3.4 years. The H : M ratio of t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000961
更新日期:2018-03-07 00:00:00
abstract::CIRCLING training (CT) decreases muscarinic acetyl-choline receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 mont...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00018
更新日期:1996-11-04 00:00:00
abstract::We evaluated the effects of chemical lesions on hindpaw inflammation-induced Fos protein expression in spinoparabrachial neurons that were retrogradely labeled by Fluoro-Gold. The descending serotoninergic and noradrenergic pathways were destroyed by the selective neurotoxins, 5,7-DHT and DSP-4, respectively. After 5,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199906030-00024
更新日期:1999-06-03 00:00:00
abstract::The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smok...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200011270-00047
更新日期:2000-11-27 00:00:00
abstract::It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199402000-00009
更新日期:1994-02-24 00:00:00
abstract::The effect of thyroid hormone (TH) deficiency on the expression of neurofilament (NF) proteins and their intracellular distribution has been examined in primary cultures of neurons from embryonic rat cerebra. Northern blot analysis showed that in TH-deficient (THdef) neurons, the expression of all three NF mRNAs (NF-L...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200008210-00022
更新日期:2000-08-21 00:00:00
abstract::The present study assessed the binding characteristics of [125I]angiotensin II to slices of human cerebellum adhered to glass slides using quantitative receptor autoradiography. Specific [125I]angiotensin II binding, defined by the inclusion of unlabelled angiotensin II (1.0 microM), was detected in the molecular laye...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199110000-00013
更新日期:1991-10-01 00:00:00
abstract::The role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283533692
更新日期:2012-05-09 00:00:00
abstract::Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DN...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00015
更新日期:1996-01-31 00:00:00
abstract::The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-03 00:00:00
abstract::In the current study we explored the relationship between neurometabolites measured by proton magnetic resonance spectroscopy (1H-MRS) and cognitive ability assessed with a battery of neuropsychological tests. Forty-five participants were recruited from the local college community, and examined utilizing neuropsycholo...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199911080-00014
更新日期:1999-11-08 00:00:00
abstract::A tritiated specific and highly potent 5-HT4 antagonist: [3H]-GR113808 was used to label specific binding sites in human brain and for comparison in guinea-pig brain. [3H]-GR113808 association and dissociation were rapid, the binding was saturable and displaced by various serotoninergic agents with an affinity corresp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199309000-00007
更新日期:1993-09-10 00:00:00
abstract::Whereas facial emotion recognition protocols have shown that each discrete emotion has a specific time course of brain activation, there is no electrophysiological evidence to support these findings for emotional induction by complex pictures. Our objective was to specify the differences between the time courses of br...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000016
更新日期:2013-11-13 00:00:00
abstract::A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the pr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105080-00018
更新日期:2001-05-08 00:00:00
abstract::This study demonstrates the neural system potentially involved in the representation of, and choice between, stimulus classifications in an ambiguous, novel, decision-making task. This difficult choice behaviour is taken as an example of a basic executive processing task. Subjects heard sounds that were consonant-vowe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
abstract::Two monkeys were trained in a delayed sequential motor task in which the time interval between events and the delay duration were either fixed or variable. Single-unit neuronal activity was recorded in the pre-supplementary motor area (pre-SMA). During the delay, we observed a gradual increase in activity (build-up pa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000127347.87552.87
更新日期:2004-06-07 00:00:00
abstract::The pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGFbeta). In normal control retinas, intense immunostaining of APP and B...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902250-00012
更新日期:1999-02-25 00:00:00
abstract::Amygdala and insula hyper-reactivity to threat is implicated in social anxiety disorder (SAD) yet inconsistencies in activation have been reported. One source of variance are individual differences in 5-HTTLPR genotype where the short (S), relative to long (L) allele, corresponds with greater amygdala activation. Howe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000210
更新日期:2014-08-20 00:00:00
abstract::Bilateral voluntary contractions involve functional changes in both primary motor cortices. However how the unilateral voluntary contraction of hand muscles influences the contralateral corticomuscular synchronous oscillations mechanisms remains unclear. In the bimanual tasks, nine healthy subjects were instructed to ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001409
更新日期:2020-03-04 00:00:00
abstract::Protease-activated receptor-2 (PAR-2), a member of the G protein-coupled, seven trans-membrane domain receptor family, is activated by trypsin/tryptase and present in various tissues including the primary sensory neurons, playing a role in development of neurogenic inflammation. The present study examined if activatio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00020
更新日期:2001-03-26 00:00:00
abstract::Fragile X syndrome is a neurodevelopmental disorder caused by a trinucleotide (CGG) hyperexpansion in the FMR1 gene, functionally silencing transcription of the fragile X mental retardation protein (FMRP). This disorder is characterized by impaired cognition, communication, and social behavior. The aim of this study w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000701
更新日期:2016-12-14 00:00:00
abstract::Temporal changes of serotonin (5-HT) content in the median (MRN) and dorsal (DRN) raphe nuclei were measured in rats kept under various lighting conditions. Serotonin content in the MRN and DRN under light-dark (LD) condition showed diurnal rhythmicity, with a peak during early light phase and a trough during the dark...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199310000-00012
更新日期:1993-10-25 00:00:00
abstract:OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001582
更新日期:2021-01-18 00:00:00
abstract::Somatosensory evoked fields were recorded to determine the effects of movement and attention on high-frequency oscillations during active finger movements of the ipsilateral and contralateral sides in response to electrical stimulation of the median nerve. A whole-scalp neuromagnetometer was used to record somatosenso...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200210280-00006
更新日期:2002-10-28 00:00:00
abstract::Three forms of non-injurious ischemic preconditioning were tested for their effects on endogenous antioxidant activity and subsequent ischemic injury. Test ischemia alone, consisting of 1 h occlusion of both carotid arteries (BCAs) and one middle cerebral artery (MCA), elicited an average volume of cerebral infarction...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703030-00008
更新日期:1997-03-03 00:00:00