Abstract:
:It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult rats. Thus, transection of the sciatic nerve resulted in markedly increased levels of trkB mRNA in axotomized motoneurones three days postinjury, while the levels had returned to normal within three weeks. The data support that neurotrophins may be important for survival and/or regeneration of motoneurones after axon lesion.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Piehl F,Frisén J,Risling M,Hökfelt T,Cullheim Sdoi
10.1097/00001756-199402000-00009subject
Has Abstractpub_date
1994-02-24 00:00:00pages
697-700issue
6eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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