Abstract:
:Depression is present in a large proportion of patients suffering from chronic pain, and yet the underlying mechanisms remain to be elucidated. Neuroligins (NLs), as a family of cell-adhesion proteins, are involved in synaptic formation and have been linked to various neuropsychiatric disorders. Here, we studied the alterations in NL1 and NL2 in the medial prefrontal cortex (mPFC), the anterior cingulate cortex (ACC), and the hippocampus in a rat model of neuropathic pain-induced depression, and whether ketamine, a rapid and robust antidepressant, could restore these abnormalities. In the present study, we found that spared nerve injury induced significant mechanical allodynia and subsequent depressive-like symptoms, along with decreased NL1 and increased NL2 in the mPFC, decreased NL1 in the ACC, and decreased NL2 in the hippocampus. In addition, brain-derived neurotrophic factor (BDNF) was reduced in these brain regions. It is noteworthy that ketamine (10 mg/kg) relieved neuropathic pain-induced depressive behaviors and restored alterations of BDNF and NLs in the mPFC and the hippocampus at 24 h and 72 h after the administration of ketamine, but only restored BDNF in the ACC. In conclusion, NLs showed diverse changes in different brain regions in the rat model of neuropathic pain-induced depression, which could be reversed differentially by the administration of ketamine.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Pan W,Zhang GF,Li HH,Ji MH,Zhou ZQ,Li KY,Yang JJdoi
10.1097/WNR.0000000000001045subject
Has Abstractpub_date
2018-07-04 00:00:00pages
863-869issue
10eissn
0959-4965issn
1473-558Xjournal_volume
29pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00022
更新日期:1998-11-16 00:00:00
abstract::Using a guessing paradigm we measured visual sensitivity in the blind and normal half-fields of four cerebrally hemidecorticated patients. In the blind field, sensitivity was reduced by approximately 3 long units. Stimuli which produced significant detection also evoked conscious sensations of light and colour. Contro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199608120-00027
更新日期:1996-08-12 00:00:00
abstract::Protease-activated receptor-2 (PAR-2), a member of the G protein-coupled, seven trans-membrane domain receptor family, is activated by trypsin/tryptase and present in various tissues including the primary sensory neurons, playing a role in development of neurogenic inflammation. The present study examined if activatio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200103260-00020
更新日期:2001-03-26 00:00:00
abstract::Currents from the slowly adapting stretch receptor neuron of the crayfish (Pacifastacus leniusculus) were studied in a cell attached configuration using patch pipettes with an opening diameter of 2-10 microm. The neuronal membrane was enzymatically freed from the glial layer. The voltage gated Na+ and K+ channels seem...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908200-00013
更新日期:1999-08-20 00:00:00
abstract::To test for the feature specificity of adaptation of auditory-cortex magnetoencephalographic N1m responses to phonemes during lipreading, we presented eight healthy volunteers with a simplified sine-wave first-formant (F1) transition shared by /ba/, /ga/, and /da/, and a continuum of second-formant (F2) transitions co...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f36f7a
更新日期:2008-01-08 00:00:00
abstract::S100B is a calcium-binding protein expressed and secreted by astrocytes, playing a neurotrophic role in neighboring cells. A protective role of the S100B against glutamate-induced excitotoxicity has recently been proposed. We investigated S100B secretion in rat hippocampal astrocytes exposed to high concentrations of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200208270-00009
更新日期:2002-08-27 00:00:00
abstract::Alpha-Synuclein is a major component of neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA), one of the alpha-synucleinopathies. Recent studies have shown that beta-synuclein, a homolog of alpha-synuclein, inhibits alpha-synuclein aggregation in vitro. We immunohistochemically examined the MSA b...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310060-00005
更新日期:2003-10-06 00:00:00
abstract::Voltage-gated sodium channels (VGSCs) are concentrated in the postsynaptic membrane at the adult rat neuromuscular junction (NMJ). We have used immunolabelling to determine the pattern of initial VGSC accumulation during development. At birth, but not 3 days before, VGSC labelling is detectable at the NMJ and in the p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199806220-00014
更新日期:1998-06-22 00:00:00
abstract::TECTA and DFNA5 are the mouse orthologues of the human deafness-associated genes TECTA and DFNA5. To determine how expression of these genes is regulated during development, relative mRNA abundance was examined in mice by non-radioactive RT-PCR. TECTA mRNA was detected on embryonic day 15 (E15), increased to its highe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200110290-00016
更新日期:2001-10-29 00:00:00
abstract::Neural plasticity in the visual cortex, as tested by changes in its functional organization induced by monocular deprivation (MD), is present only during a restricted period of postnatal development (critical period). To investigate whether this process of synapse strengthening depends upon NGF, we antagonized endogen...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199410270-00013
更新日期:1994-10-27 00:00:00
abstract::Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0b542
更新日期:2007-10-29 00:00:00
abstract::Human somatosensory evoked potentials (SEP) contain high-frequency (600 Hz) wavelet bursts possibly reflecting repetitive population spikes in thalamocortical axons and/or postsynaptic responses. To dissociate thalamic and cortical burst components the recovery of intrathalamic SEP (derived from electrodes implanted f...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200004270-00030
更新日期:2000-04-27 00:00:00
abstract::We investigated whether cerebellar transcranial magnetic stimulation (C-TMS) facilitates the excitability of the ipsilateral soleus motoneuron pool in resting humans, and whether the facilitation is modulated by a task that promotes cerebellar activity. A test tibial nerve stimulus evoking the H-reflex from the right ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000275
更新日期:2014-12-03 00:00:00
abstract::The present study used scores from Seligman's Attribution Style Questionnaire and [15O] water positron emission tomographic measurements of regional cerebral blood flow (rCBF) to investigate the relation between individual differences in dispositional pessimism and amygdala activity. During scanning 13 healthy non-sna...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00024
更新日期:2001-06-13 00:00:00
abstract::As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00015
更新日期:2001-08-08 00:00:00
abstract::The reduced steroids 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and 3 alpha,21-di-hydroxy-5 alpha-pregnan-20-one (allotetrahydroDOC) are potent ligands of GABAA receptors. This study examined the possible modulatory effect of these metabolites on GABA inhibition of somatostatin release in cultured hypot...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199510020-00025
更新日期:1995-10-02 00:00:00
abstract::Ascorbate and glutathione (GSH) are the primary water-soluble antioxidants in the CNS. Oxidative stress, sometimes indicated by loss of these antioxidants, has been linked to several clinical and experimental conditions, including cerebral ischemia. These conditions are also gender-linked, with greater incidence or se...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507310-00005
更新日期:1995-07-31 00:00:00
abstract::The cellular distribution of the type VI human voltage-gated sodium channel (Type VI) was examined in selected human brain regions. Antibodies designed to be specific to rat and human Type VI were raised against a synthetic peptide from the predicted NH2-terminal of the protein, and used for an immunohistochemical inv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00044
更新日期:1999-11-26 00:00:00
abstract::Items in working memory guide visual attention toward a memory-matching object. Recent studies have shown that when searching for an object this attentional guidance can be modulated by knowing the probability that the target will match an item in working memory. Here, we recorded the P3 and contralateral delay activi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000545
更新日期:2016-03-23 00:00:00
abstract::The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful fac...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e328310af58
更新日期:2008-10-08 00:00:00
abstract::Children with mathematical difficulties usually have an impaired ability to process symbolic representations. Functional MRI methods have suggested that early frontoparietal connectivity can predict mathematic achievements; however, the study of brain connectivity during numerical processing remains unexplored. With t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000722
更新日期:2017-02-08 00:00:00
abstract::The acute effects of ethanol and acetaldehyde on neuropeptide mRNA expression in the arcuate nucleus (ARC) was assessed. Acetaldehyde was increased in blood following ethanol with cyanamide (a potent inhibitor of aldehyde dehydrogenase) administration. Acetaldehyde is a toxin which can cause a variety of adverse effec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00023
更新日期:2000-11-09 00:00:00
abstract::We examined the cortical areas showing increased activation related to axis orientation discrimination in hand movement and perception by positron emission tomography (PET) in right-handed normal human subjects while they performed a hand orientation (HO) task and an orientation discrimination (OD) task. In the OD tas...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199801260-00020
更新日期:1998-01-26 00:00:00
abstract::The effects of interleukin-1beta in the paraventricular nucleus or caudal arcuate nucleus on hypertensive and tachycardiac responses induced by excitation of the central amygdaloid nucleus were studied. We observed that microinjection of sodium glutamate into central amygdaloid nucleus resulted in hypertension and tac...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200203250-00039
更新日期:2002-03-25 00:00:00
abstract::In situ hybridization has demonstrated mRNA for olfactory receptors (OR) in the axon terminals of olfactory receptor neurons. Neurons that express the same OR appear to send their axons to two stereotyped glomeruli in the olfactory bulb (OB). Based on these observations, we tested the feasibility of using RT-PCR to is...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00032
更新日期:1998-11-16 00:00:00
abstract::To investigate the neural substrates for the perception of motion and of position in depth, we examined the changes in regional cerebral blood flow during positional and motion stereopsis in humans by positron emission tomography. During positional stereopsis, the right striate and peristriate cortices (areas V1/V2 an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199607290-00004
更新日期:1996-07-29 00:00:00
abstract::We examined the effect of a nonphotic stimulus (running in a novel wheel) on the induction of Fos-related proteins in the two well-established neural components of the circadian clock: the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) of the lateral geniculate complex. There was no induction of F...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199207000-00007
更新日期:1992-07-01 00:00:00
abstract::In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000236862.08834.50
更新日期:2006-11-06 00:00:00
abstract::While dopamine mechanisms play a crucial role in cocaine-taking behavior, the contribution of endogenous opioid systems is less clear. We assessed the effects of opioid receptor blockade by naloxone (1 mg/kg, s.c.) on the daily performance and subsequent initiation of cocaine self-administration in trained rats. Nalox...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200302100-00019
更新日期:2003-02-10 00:00:00
abstract::Chronic nicotine exposure enhances axon reflexes in adult rats. Since smoking mothers expose their infants to nicotine, this study investigated whether late gestational and or lactational maternal nicotine exposure affects neonatal axon reflexes. Osmotic pumps, implanted subcutaneously in adult female rats, delivered ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00008
更新日期:1993-06-01 00:00:00