Abstract:
:Neural plasticity in the visual cortex, as tested by changes in its functional organization induced by monocular deprivation (MD), is present only during a restricted period of postnatal development (critical period). To investigate whether this process of synapse strengthening depends upon NGF, we antagonized endogenous NGF during the critical period by implanting anti-NGF producing cells. Anti-NGF treated and control rats were monocularly deprived after the end of the critical period. In anti-NGF treated but not in control rats MD was still effective. We conclude that antagonism of endogenous NGF prolongs the critical period, possibly by delaying the process of synapse consolidation in the visual cortex.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Domenici L,Cellerino A,Berardi N,Cattaneo A,Maffei Ldoi
10.1097/00001756-199410270-00013subject
Has Abstractpub_date
1994-10-27 00:00:00pages
2041-4issue
16eissn
0959-4965issn
1473-558Xjournal_volume
5pub_type
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