N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia.

abstract：:Amyloid beta-peptide (A beta) is a major component of neuritic plaques, a feature of Alzheimer's disease (AD) brains. Recently, we showed that A beta adopts two major conformational states in solution, which differ in their abilities to form amyloid. These are highly amyloidogenic conformer (A beta ac) with a high con...

journal_title：Neuroreport

authors： Soto C,Golabek A,Wisniewski T,Castaño EM

更新日期：1996-02-29 00:00:00

abstract：:Target detection is the process of bringing a salient stimulus into conscious awareness. Target detection evokes a prominent event-related potential (ERP) component (P3) in the electroencephalogram (EEG). We combined the high spatial resolution of functional magnetic resonance imaging (fMRI) with the high temporal res...

journal_title：Neuroreport

authors： Menon V,Ford JM,Lim KO,Glover GH,Pfefferbaum A

更新日期：1997-09-29 00:00:00

abstract：:Prior work has shown that kappa opioids may attenuate the effects of analgesic mu receptor agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia following exposure to a signal for shock is attenuated by infusions of the kappa agonist U69593 into the rostral ventromedial m...

journal_title：Neuroreport

authors： Foo H,Helmstetter FJ

更新日期：2000-10-20 00:00:00

abstract：:The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma cor...

journal_title：Neuroreport

authors： Tahera Y,Meltser I,Johansson P,Canlon B

更新日期：2006-06-26 00:00:00

abstract：:A combined microdialysis/microinfusion technique was used to investigate whether arginine vasopressin (AVP) is involved in the regulation of its own release into the extracellular fluid of the supraoptic nucleus in vivo. While intranuclear neuropeptide release was monitored, 0.33 microliter of either vehicle, lysine v...

journal_title：Neuroreport

authors： Wotjak CT,Ludwig M,Landgraf R

更新日期：1994-06-02 00:00:00

abstract：:It is well known that perceiving another person's body movements activates corresponding motor representations in an observer's brain, a process which appears to be imitative in nature. However, it is also true that simply imitating another person's action/s in many situations is not an effective or appropriate respon...

journal_title：Neuroreport

authors： Sartori L,Betti S,Castiello U

更新日期：2013-08-07 00:00:00

abstract：:Diffusion tensor imaging is a new in vivo tool not only for the assessment of white matter structural integrity but also for diagnosis and assessment of disease conditions which disturb tissue structural coherence. In this study, we investigated the integrity of auditory pathway in patients of sensorineural hearing lo...

journal_title：Neuroreport

authors： Chang Y,Lee SH,Lee YJ,Hwang MJ,Bae SJ,Kim MN,Lee J,Woo S,Lee H,Kang DS

更新日期：2004-08-06 00:00:00

abstract：:Intracellular recordings of activity in response to acoustic stimuli were obtained from units of the dentate nucleus of conscious cats. Twelve units with short latency responses to 70 dB clicks or hisses were injected intracellularly with biocytin and identified morphologically. The identified cells were small, relati...

journal_title：Neuroreport

authors： Xi MC,Woody CD,Gruen E

更新日期：1994-08-15 00:00:00

abstract：:Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...

journal_title：Neuroreport

authors： Smith MA,Zhang LX,Lyons WE,Mamounas LA

更新日期：1997-05-27 00:00:00

abstract：:Event-related potential (ERP) studies have shown that responses to illusory (IC), as compared to no contours (NC), may differ within 200 ms following stimulus presentation. However, whether these responses reflect the modulation of similar, or the activation of distinct brain regions has never been assessed. Using ERP...

journal_title：Neuroreport

authors： Pegna AJ,Khateb A,Murray MM,Landis T,Michel CM

更新日期：2002-05-24 00:00:00

abstract：:To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan...

journal_title：Neuroreport

authors： Funayama M,Li Y,Tomiyama H,Yoshino H,Imamichi Y,Yamamoto M,Murata M,Toda T,Mizuno Y,Hattori N

更新日期：2007-02-12 00:00:00

abstract：:Experience affects how brains respond to sound. Here, we examined how the sensitivity and selectivity of auditory cortical neuronal responses were affected in adult rats by the repeated presentation of a complex sound that was paired with basal forebrain stimulation. The auditory cortical region that was responsive to...

journal_title：Neuroreport

authors： Mercado E,Bao S,Orduña I,Gluck MA,Merzenich MM

更新日期：2001-07-20 00:00:00

abstract：:Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD...

journal_title：Neuroreport

authors： Love S,Nicoll JA,Hughes A,Wilcock GK

更新日期：2003-08-06 00:00:00

abstract：:Functional brain imaging techniques hold many promises as the methods of choice for identifying areas involved in the execution of language functions. The success of any of these techniques in fulfilling this goal depends upon their ability to produce maps of activated areas that overlap with those obtained through st...

journal_title：Neuroreport

authors： Simos PG,Breier JI,Maggio WW,Gormley WB,Zouridakis G,Willmore LJ,Wheless JW,Constantinou JE,Papanicolaou AC

更新日期：1999-01-18 00:00:00

abstract：OBJECTIVES:The aim of this study was to determine the expression level of immunoproteasome and its clinical significance in glioma preliminarily. Furthermore, we studied the function and molecular mechanism of proteasome inhibitor ONX 0912 on glioma cell. MATERIALS AND METHODS:The expression of immunoproteasome in gli...

journal_title：Neuroreport

authors： Min L,Zeng X,Li B,Tao B,Shi J,Zhang W,Sun Q,Jing C,Wang X

更新日期：2019-10-16 00:00:00

abstract：:Pharmacologically distinct NMDA-glutamate receptor subtypes have been reported in brain. We have studied the developmental expression of the mRNA encoding the NMDA receptor NR2C subunit in the rat brain by in situ hybridization. In contrast with the adult where no hybridization signal was detected in the hippocampus, ...

journal_title：Neuroreport

authors： Pollard H,Khrestchatisky M,Moreau J,Ben Ari Y

更新日期：1993-04-01 00:00:00

abstract：:Age-related depletion of androgens in men results in functional impairments in androgen-responsive tissues, such as the brain, resulting in increased risk for Alzheimer's disease. To investigate the relationship between normal age-related hormone loss and Alzheimer's disease risk, we evaluated the brain and serum leve...

journal_title：Neuroreport

authors： Rosario ER,Chang L,Beckett TL,Carroll JC,Paul Murphy M,Stanczyk FZ,Pike CJ

更新日期：2009-11-25 00:00:00

abstract：:We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontin...

journal_title：Neuroreport

authors： Borday V,Kato F,Champagnat J

更新日期：1997-12-01 00:00:00

abstract：:We recorded auditory evoked magnetic fields (AEFs) by presenting pure tone bursts once every 4000 ms in 11 patients with a brain lesion in or in the vicinity of the auditory cortex. AEFs on the damaged side revealed several enhanced deflections in late-latency AEFs (slow AEFs), peaking at approximately 320 (DI), 1030 ...

journal_title：Neuroreport

authors： Kamada K,Takeuchi F,Harada T,Qiao B,Houkin K,Kuriki S,Iwasaki Y,Mitsumori K

更新日期：2001-05-08 00:00:00

abstract：:There is abundant psychophysical evidence in humans suggesting the existence of parallel pathways subserving different aspects of vision. However, there is little direct proof of the neural structures underlying the two pathways. We present direct anatomical evidence that in the normal human optic tract fibres are seg...

journal_title：Neuroreport

authors： Tassinari G,Campara D,Balercia G,Chilosi M,Martignoni G,Marzi CA

更新日期：1994-07-21 00:00:00

abstract：:There has been intense interest in determining how the visual brain processes the outside world, and in identifying the neuroanatomical correlates of the ability to create art. Comparing art production before and after illness onset permits some speculation on the function of selective brain regions affected by the ne...

journal_title：Neuroreport

authors： Kleiner-Fisman G,Lang AE

更新日期：2004-04-29 00:00:00

abstract：:Previous studies in adult rats have demonstrated that the neurotrophin, brain-derived neurotrophic factor (BDNF), is present in virtually all cells of the pituitary intermediate lobe. In the present study, we demonstrate that cells cultured from adult intermediate lobe pituitary (ILP) rapidly lose their BDNF immunorea...

journal_title：Neuroreport

authors： Höpker VH,Kjaer B,Varon S

更新日期：1997-03-24 00:00:00

abstract：:Is functional neuroimaging a royal way to understand brain function or is it a new phrenology without an exact understanding what we measure? After two decades of imaging revolution, more and more authors ask this question. Brain functions are multidimensional, which can be approached from the point of (1) behavioural...

journal_title：Neuroreport

authors： Kéri S,Gulyás B

更新日期：2003-06-11 00:00:00

abstract：:Animal studies have shown brain ischaemia to cause oxidative damage to DNA and activation of caspase-3, leading to apoptosis. These changes may be exacerbated by reperfusion. To assess caspase-3 activation after transient and permanent brain ischaemia in man, we examined brain tissue from patients who had experienced ...

journal_title：Neuroreport

authors： Love S,Barber R,Srinivasan A,Wilcock GK

更新日期：2000-08-03 00:00:00

abstract：:Methylphenidate (Ritalin) is a psychostimulant drug used to treat children with attention deficit hyperactivity disorder. Despite its widespread and increasing clinical use, little is known about the long-term consequences of drug treatment. We compared the effects of a single injection of methylphenidate with that of...

journal_title：Neuroreport

authors： Chase TD,Brown RE,Carrey N,Wilkinson M

更新日期：2003-04-15 00:00:00

abstract：:The localization of PKC gamma mRNA expression during the maturation of rat cerebellum has been studied by in situ hybridization. We found a transient expression over the granule cell layer and persistent high expression in the Purkinje cells during postnatal development. Expression in granule cells appeared as early a...

journal_title：Neuroreport

authors： Herms J,Zurmöhle U,Schlingensiepen KH,Brysch W

更新日期：1993-07-01 00:00:00

abstract：:The serotonin transporter (SERT) terminates serotonergic neurotransmission by rapid reuptake of 5-hydroxytryptamine (5-HT) into the nerve terminal or axonal varicosities. SERT represents the target of various antidepressants which inhibit 5-HT transport and are widely used for the pharmacotherapy of depression. Here, ...

journal_title：Neuroreport

authors： Horschitz S,Hummerich R,Schloss P

更新日期：2001-07-20 00:00:00

abstract：:The H-Tx rat is a polygenic inherited model of hydrocephalus. In order to identify disease-specific biomarkers associated with congenital hydrocephalus, comparative proteomic analysis was used to screen cerebellum proteins in H-Tx rats at 1 day after birth. Seven proteins showed significant changes in hydrocephalic H-...

journal_title：Neuroreport

authors： Li X,Miyajima M,Mineki R,Taka H,Murayama K,Arai H

更新日期：2005-04-25 00:00:00

abstract：:Removal of the labyrinthine organs on one side results in static and dynamic disturbances. Some functional recovery occurs over time and is paralleled in frogs by an increase in the efficacy of central vestibular pathways. Here, we report concomitant increases in dorsal root evoked ventral root responses in the brachi...

journal_title：Neuroreport

authors： Straka H,Kunkel A,Dieringer N

更新日期：1993-09-01 00:00:00

abstract：:Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...

journal_title：Neuroreport

authors： Root JC,Tuescher O,Cunningham-Bussel A,Pan H,Epstein J,Altemus M,Cloitre M,Goldstein M,Silverman M,Furman D,Ledoux J,McEwen B,Stern E,Silbersweig D

更新日期：2009-03-04 00:00:00