Acute marijuana effects on rCBF and cognition: a PET study.


:The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (e.g. orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum. Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.






O'Leary DS,Block RI,Flaum M,Schultz SK,Boles Ponto LL,Watkins GL,Hurtig RR,Andreasen NC,Hichwa RD




Has Abstract


2000-11-27 00:00:00












  • Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector.

    abstract::Vectors based on lentiviruses are opening up new approaches for the treatment of neurodegenerative diseases. Currently, the equine infectious anaemia virus (EIAV) vector is one of the most attractive gene delivery systems with respect to neuronal tropism. The aim was to validate EIAV-lentiviral vectors as a gene deliv...


    pub_type: 杂志文章


    authors: Azzouz M,Ralph S,Wong LF,Day D,Askham Z,Barber RD,Mitrophanous KA,Kingsman SM,Mazarakis ND

    更新日期:2004-04-29 00:00:00

  • Nucleus basalis lesions decrease alpha- and kappa-bungarotoxins binding in rat cortex.

    abstract::A unilateral ibotenic acid lesion of the nucleus basalis magnocellularis in the rat, which is known to produce a reduction in cortical choline acetyltransferase activity and acetylcholine release, produces a decrease of 125I-alpha-bungarotoxin and 125I-kappa-bungarotoxin binding sites in the frontoparietal cortex of t...


    pub_type: 杂志文章


    authors: Sugaya K,Downen M,Giacobini E

    更新日期:1991-04-01 00:00:00

  • Developmental changes in optokinetic mechanisms in the absence of unilateral cortical control.

    abstract::Animal models suggest that the asymmetry of monocular optokinetic nystagmus (OKN) in young infants can be explained by a direct pathway from retina to the midbrain nucleus of the optic tract. However, earlier studies with hemispherectomized infants showed no evidence for OKN responses towards the damaged cortex that c...


    pub_type: 杂志文章


    authors: Morrone MC,Atkinson J,Cioni G,Braddick OJ,Fiorentini A

    更新日期:1999-09-09 00:00:00

  • ErbB receptors modulation in different types of peripheral nerve regeneration.

    abstract::ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model....


    pub_type: 杂志文章


    authors: Audisio C,Nicolino S,Scevola A,Tos P,Geuna S,Battiston B,Perroteau I

    更新日期:2008-10-29 00:00:00

  • Age-related multisensory enhancement in a simple audiovisual detection task.

    abstract::Older adults are known to gain more than younger adults from the simultaneous presentation of semantically congruent sensory stimuli. Although these findings are quite exciting, they may not solely be due to age-related differences in multisensory processing. Rather, enhanced integration may be explained by alteration...


    pub_type: 杂志文章


    authors: Peiffer AM,Mozolic JL,Hugenschmidt CE,Laurienti PJ

    更新日期:2007-07-02 00:00:00

  • Enhanced phosphorylation of S6 protein in mouse cortical layer V and subplate neurons.

    abstract::The mammalian neocortex is composed of six major layers of neurons. Each group of neurons in the cortical layers has distinct characteristics based on the expression of specific genes and connectivity patterns of neural circuits. Neuronal subtype transition and regional identity acquisition are established by temporal...


    pub_type: 杂志文章


    authors: Lee SE,Hwang S,Ahn SG,D'Arcangelo G,Lee GH

    更新日期:2020-07-10 00:00:00

  • Metabotropic glutamate receptor mGluR2/3 immunoreactivity in the mouse superior colliculus: co-localization with calbindin D28K.

    abstract::We have studied the distribution of mGluR2/3 in the mouse superior colliculus (SC) with antibody immunocytochemistry and the effect of enucleation on this distribution. We also compared this labeling to that for calbindin D28K. Anti-mGluR2/3-immunoreactive (IR) cells formed distinctive laminar patterns within the lowe...


    pub_type: 杂志文章


    authors: Kim MA,Jeon CJ

    更新日期:1999-04-26 00:00:00

  • Beta-frequency EEG activity increased during transcranial direct current stimulation.

    abstract::Transcranial direct current stimulation (tDCS) is a technique for noninvasively stimulating specific cortical regions of the brain with small (<2 mA) and constant direct current on the scalp. tDCS has been widely applied, not only for medical treatment, but also for cognitive and somatosensory function enhancement, mo...


    pub_type: 杂志文章


    authors: Song M,Shin Y,Yun K

    更新日期:2014-12-17 00:00:00

  • Presenilin-1 polymorphism and amyloid beta-protein deposition in fatal head injury.

    abstract::Approximately 30% of patients with fatal head injuries have deposits of amyloid beta-protein (A beta); these are predominantly individuals carrying the epsilon 4 allele of apolipoprotein E (apoE). A beta deposition occurs in Alzheimer's disease (AD), for which approximately 50% of the genetic risk is attributed to apo...


    pub_type: 杂志文章


    authors: Zunarelli E,Nicoll JA,Graham DI

    更新日期:1996-12-20 00:00:00

  • LTP in CA1 of the adult rat hippocampus and voltage-activated calcium channels.

    abstract::It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced b...


    pub_type: 杂志文章


    authors: Izumi Y,Zorumski CF

    更新日期:1998-11-16 00:00:00

  • Over-expression of MBP and PLP messenger RNA in 8-day-old trembler brain.

    abstract::The trembler mouse suffers from a dominantly inherited mutation of the peripheral myelin protein 22 (PMP-22) gene which results in abnormal myelination of the peripheral nervous system. However, the clinical symptoms observed in the mutant suggest abnormalities in the central nervous system. Using the Northern blot te...


    pub_type: 杂志文章


    authors: Bascles L,Bonnet J,Garbay B

    更新日期:1994-06-02 00:00:00

  • The role of precisely matching fascicles in the quick recovery of nerve function in long peripheral nerve defects.

    abstract::Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TE...


    pub_type: 杂志文章


    authors: Yan L,Yao Z,Lin T,Zhu Q,Qi J,Gu L,Fang J,Zhou X,Liu X

    更新日期:2017-10-18 00:00:00

  • Increases in K+ conductance and Ca2+ influx under high glucose with suppressed Na+/K+-pump activity in rat myelinated nerve fibers.

    abstract::To test the combined effect of high glucose and decreased Na+/K+-pump activity, a condition which closely mimics the diabetic state, on nerve ionic currents, changes in action potential and membrane current induced by high glucose in the presence of ouabain were investigated using voltage clamp analysis in rat single ...


    pub_type: 杂志文章


    authors: Takigawa T,Yasuda H,Terada M,Maeda K,Haneda M,Kashiwagi A,Kitasato H,Kikkawa R

    更新日期:2000-08-03 00:00:00

  • NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C.

    abstract::Prolonged activation of brain N-methyl-D-aspartic acid (NMDA) receptors increases intraneuronal (Ca2+) and nitric oxide (NO) synthesis, and may be responsible for neuronal death in acute brain insults and chronic neurodegenerative diseases. NO can be converted in vitro to toxic hydroxyl (OH) radical. Using microdialys...


    pub_type: 杂志文章


    authors: Hammer B,Parker WD Jr,Bennett JP Jr

    更新日期:1993-10-25 00:00:00

  • Activation of acetylcholinesterase by aluminium(III): the relevance of the metal species.

    abstract::The present paper reports how aluminium [Al(III)] at a concentration of 3.7 microM can activate the bovine erythrocytic enzyme acetylcholinesterase (AChE) by about 38% in vitro. This same activating effect was observed on AChE form human as well as from rat erythrocyte ghosts and murine neuroblastoma cells. The intera...


    pub_type: 杂志文章


    authors: Zatta P,Zambenedetti P,Bruna V,Filippi B

    更新日期:1994-09-08 00:00:00

  • Trichloroethanol alters action potentials in a subgroup of primary sensory neurones.

    abstract::We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...


    pub_type: 杂志文章


    authors: Gruss M,Hempelmann G,Scholz A

    更新日期:2002-05-07 00:00:00

  • Increased trkB mRNA expression by axotomized motoneurones.

    abstract::It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult...


    pub_type: 杂志文章


    authors: Piehl F,Frisén J,Risling M,Hökfelt T,Cullheim S

    更新日期:1994-02-24 00:00:00

  • Increased levels of TrkA in the regenerating retinal ganglion cells of fish.

    abstract::Retinal ganglion cells of the fish have the spontaneous capacity to regenerate after nerve crush, a phenomenon known to be facilitated by nerve growth factor (NGF). We have studied the high-affinity NGF receptor TrkA, during the regeneration of the tench (Tinca tinca L.) optic nerve, using immunocytochemical technique...


    pub_type: 杂志文章


    authors: Vecino E,Caminos E,Becker E,Rudkin BB,Evan GI,Martín-Zanca D

    更新日期:1998-10-26 00:00:00

  • Alpha-MSH inhibits inflammatory signalling in Schwann cells.

    abstract::Peripheral nervous system injury may be corrected by surgical repair, but in many cases this is not possible and will result in loss of motor and sensory function. Schwann cells provide many neurotrophic signals essential for axon regeneration and immediately after injury inflammatory cytokines are released necessary ...


    pub_type: 杂志文章


    authors: Teare KA,Pearson RG,Shakesheff KM,Haycock JW

    更新日期:2004-03-01 00:00:00

  • Immunofluorescent identification of a delta (delta)-opioid receptor on primary afferent nerve terminals.

    abstract::Antisera were produced against synthetic peptides predicted from the recent cloning of a delta opioid receptor, DOR-1. Confocal microscopic examination of immunostained spinal cord sections revealed that DOR-1 immunoreactive (-ir) nerve fibers and terminals form a moderately dense plexus within the superficial dorsal ...


    pub_type: 杂志文章


    authors: Dado RJ,Law PY,Loh HH,Elde R

    更新日期:1993-12-13 00:00:00

  • Evidence for a modulatory role of Ih on the firing of a subgroup of midbrain dopamine neurons.

    abstract::A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...


    pub_type: 杂志文章


    authors: Seutin V,Massotte L,Renette MF,Dresse A

    更新日期:2001-02-12 00:00:00

  • Corticotropin-releasing hormone 1 receptor antagonism attenuates chronic unpredictable mild stress-induced depressive-like behaviors in rats.

    abstract::Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant ac...


    pub_type: 杂志文章


    authors: Wang XB,Zhang YQ,Xue RR,Yang ZZ,Zhang XF

    更新日期:2020-01-08 00:00:00

  • Glaucomatous optic neuropathy causes sensitivity loss to light offsets in the visual field.

    abstract::The functional integrity of the 'on' and 'off' neurovisual pathways has been examined in the central visual fields of normal (n = 13), glaucomatous (n = 21) and ocular hypertensive (n = 21) individuals. The detection thresholds to light increments (onsets = bright spots) and light decrements (offsets = dark spots) on ...


    pub_type: 杂志文章


    authors: Mutlukan E

    更新日期:1993-09-03 00:00:00

  • The role of the left inferior temporal cortex for visual pattern discrimination--a PET study.

    abstract::We measured regional cerebral blood flow using positron emission tomography in seven normal volunteers during discrimination tasks for visual patterns. For the 'attention to right or left' tasks, the subjects were instructed to press a key when sample and test stimuli presented in the right or left visual fields, resp...


    pub_type: 杂志文章


    authors: Kawashima R,Satoh K,Goto R,Inoue K,Itoh M,Fukuda H

    更新日期:1998-05-11 00:00:00

  • Time course and specificity of event-related potentials to emotional expressions.

    abstract::To clarify the time course of neural responses to faces with different emotional expressions, we used event-related potential (ERP) and reaction time measures. Faces expressing four different emotions (happy, neutral, fearful, disgusted) and houses were shown in both upright and inverted orientations while subjects pe...


    pub_type: 杂志文章


    authors: Ashley V,Vuilleumier P,Swick D

    更新日期:2004-01-19 00:00:00

  • P2X3 receptor in injured human sensory neurons.

    abstract::The ATP-gated cation channel P2X3 is expressed selectively by rat sensory neurones, and may play a role in nociception by binding ATP released from damaged or inflamed tissues. However, the distribution of this channel in human sensory neurons is not known. Using a specific antibody, we have demonstrated intense P2X3 ...


    pub_type: 杂志文章


    authors: Yiangou Y,Facer P,Birch R,Sangameswaran L,Eglen R,Anand P

    更新日期:2000-04-07 00:00:00

  • Disordered visual processing and oscillatory brain activity in autism and Williams syndrome.

    abstract::Two developmental disorders, autism and Williams syndrome, are both commonly described as having difficulties in integrating perceptual features, i.e. binding spatially separate elements into a whole. It is already known that healthy adults and infants display electroencephalographic (EEG) gamma-band bursts (around 40...


    pub_type: 临床试验,杂志文章


    authors: Grice SJ,Spratling MW,Karmiloff-Smith A,Halit H,Csibra G,de Haan M,Johnson MH

    更新日期:2001-08-28 00:00:00

  • The role of Ca2+ channels in the repetitive firing of striatal projection neurons.

    abstract::Blockade of L-type Ca2+ channels results in a decrease in firing frequency of neostriatal neurons. In contrast, N- and P/Q-types of Ca2+ channel cooperate to tune firing pattern, since both of these channel types have to be blocked to enhance firing frequency. Parameters of the intensity-frequency plot were differenti...


    pub_type: 杂志文章


    authors: Pérez-Garci E,Bargas J,Galarraga E

    更新日期:2003-07-01 00:00:00

  • Neuronal IFN-gamma in tuberomammillary neurones.

    abstract::Neuronal interferon-gamma (N-IFN-gamma), recently isolated from the nervous system, has a molecular weight distinct from that of lymphocyte-derived IFN-gamma, but crossreacts immunologically and shares certain bioactivities with this cytokine. In the rat brain N-IFN-gamma-immunoreactive perikarya were concentrated in ...


    pub_type: 杂志文章


    authors: Bentivoglio M,Florenzano F,Peng ZC,Kristensson K

    更新日期:1994-12-20 00:00:00

  • Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia.

    abstract::The potent and selective AMPA receptor antagonist NBQX was tested for cytoprotective properties in an adult rat model of transient focal neocortical ischemia. Nineteen spontaneously hypertensive rats sustained 2 h of middle cerebral artery occlusion, followed by 22 h of recirculation. Ninety minutes following the onse...


    pub_type: 杂志文章


    authors: Buchan AM,Xue D,Huang ZG,Smith KH,Lesiuk H

    更新日期:1991-08-01 00:00:00