Acute marijuana effects on rCBF and cognition: a PET study.

Abstract:

:The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (e.g. orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum. Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.

journal_name

Neuroreport

journal_title

Neuroreport

authors

O'Leary DS,Block RI,Flaum M,Schultz SK,Boles Ponto LL,Watkins GL,Hurtig RR,Andreasen NC,Hichwa RD

doi

10.1097/00001756-200011270-00047

subject

Has Abstract

pub_date

2000-11-27 00:00:00

pages

3835-41

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

11

pub_type

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