ErbB receptors modulation in different types of peripheral nerve regeneration.

Abstract:

:ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model. Expression of ErbBs was assessed at 7, 14, and 28 days postoperatively by real-time PCR. Results showed that expression of ErbB1 and ErbB4 mRNAs was downregulated, whereas ErbB3 mRNA was upregulated. No significant changes in ErbB2 mRNA were detected. Our results suggest that ErbBs changes are involved in the molecular response to peripheral nerve injuries.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Audisio C,Nicolino S,Scevola A,Tos P,Geuna S,Battiston B,Perroteau I

doi

10.1097/WNR.0b013e32831313ef

subject

Has Abstract

pub_date

2008-10-29 00:00:00

pages

1605-9

issue

16

eissn

0959-4965

issn

1473-558X

pii

00001756-200810290-00010

journal_volume

19

pub_type

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