Distribution of Smoothened at hippocampal mossy fiber synapses.

Abstract:

:The seven-transmembrane receptor Smoothened is essential for hedgehog signal transduction. In adulthood, the highest density of Smoothened mRNA is found in the granule cell layer of the dentate gyrus. There, Smoothened expression is regulated by the synaptic activity involving the glutamatergic transmission. The precise localization of Smoothened proteins, however, has not yet been reported. Here, we describe Smoothened protein distribution in the hippocampal mossy fibers using specific Smoothened antibodies. We provide evidences for their presynaptic localization, and using electron microscopy, show that Smoothened is located in close association with synaptic vesicles and rarely with the plasma membrane. These findings demonstrate that Smoothened is localized presynaptically and suggest that Smoothened signal transduction may be implicated in the complex aspects of mossy fiber function.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Masdeu C,Bernard V,Faure H,Traiffort E,Ruat M

doi

10.1097/WNR.0b013e32801421ce

subject

Has Abstract

pub_date

2007-03-05 00:00:00

pages

395-9

issue

4

eissn

0959-4965

issn

1473-558X

pii

00001756-200703050-00020

journal_volume

18

pub_type

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