Abstract:
:The seven-transmembrane receptor Smoothened is essential for hedgehog signal transduction. In adulthood, the highest density of Smoothened mRNA is found in the granule cell layer of the dentate gyrus. There, Smoothened expression is regulated by the synaptic activity involving the glutamatergic transmission. The precise localization of Smoothened proteins, however, has not yet been reported. Here, we describe Smoothened protein distribution in the hippocampal mossy fibers using specific Smoothened antibodies. We provide evidences for their presynaptic localization, and using electron microscopy, show that Smoothened is located in close association with synaptic vesicles and rarely with the plasma membrane. These findings demonstrate that Smoothened is localized presynaptically and suggest that Smoothened signal transduction may be implicated in the complex aspects of mossy fiber function.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Masdeu C,Bernard V,Faure H,Traiffort E,Ruat Mdoi
10.1097/WNR.0b013e32801421cesubject
Has Abstractpub_date
2007-03-05 00:00:00pages
395-9issue
4eissn
0959-4965issn
1473-558Xpii
00001756-200703050-00020journal_volume
18pub_type
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