Abstract:
:To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid release induced by both sPLA and glutamate was partially blocked by MK-801, indicating that the glutamate-NMDA-cPLA pathway contributes to sPLA -induced arachidonic acid release. Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kolko M,de Turco EB,Diemer NH,Bazan NGdoi
10.1097/00001756-200210280-00026subject
Has Abstractpub_date
2002-10-28 00:00:00pages
1963-6issue
15eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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