Abstract:
:Experimental and clinical studies have revealed that angiotensin II type 1 receptor blocker has protective effects against ischemic brain injury, but the mechanism is still obscure. Angiotensin II type 1 receptor blocker may also have effects on neurogenesis through the activation of unblocked angiotensin II type 2 receptors. In this study, we showed that valsartan significantly suppressed superoxide production and cytochrome C release into the cytosol after transient forebrain ischemia and consequently attenuated ischemic neuronal damage without affecting the blood pressure in rats. However, valsartan has none of the expected effects on neurogenesis after ischemia. These results suggest that valsartan has neuroprotective effects on ischemic injury through the suppression of oxidative stress and mitochondrial injury.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wakai T,Yoshioka H,Yagi T,Kato T,Kinouchi Hdoi
10.1097/WNR.0b013e328346be84subject
Has Abstractpub_date
2011-06-11 00:00:00pages
385-90issue
8eissn
0959-4965issn
1473-558Xjournal_volume
22pub_type
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