Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat.

Abstract:

:We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a small dose of dizocilpine (0.15 mg kg-1) induced inspiratory pauses and respiratory arrest in the inspiratory phase (apneusis). Similarly, larger doses of either NBQX or dizocilpine did not induce apneusis but the addition of a small dose of the other compound provoked an apneusis. Thus, a blockade of either non-NMDA or NMDA receptors is well tolerated, but the combined blockade of both receptor types severely disrupts the respiratory function in the cat.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Foutz AS,Pierrefiche O,Denavit-Saubié M

doi

10.1097/00001756-199401120-00028

subject

Has Abstract

pub_date

1994-01-12 00:00:00

pages

481-4

issue

4

eissn

0959-4965

issn

1473-558X

journal_volume

5

pub_type

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