Combined blockade of NMDA and non-NMDA receptors produces respiratory arrest in the adult cat.


:We studied the effects of the non-NMDA antagonist NBQX and of the NMDA antagonist dizocilpine (MK-801), administered separately or together, on the respiratory function of conscious cats. NBQX (20 mg kg-1) did not affect minute ventilation nor the timing of inspiratory and expiratory phases, but the addition of a small dose of dizocilpine (0.15 mg kg-1) induced inspiratory pauses and respiratory arrest in the inspiratory phase (apneusis). Similarly, larger doses of either NBQX or dizocilpine did not induce apneusis but the addition of a small dose of the other compound provoked an apneusis. Thus, a blockade of either non-NMDA or NMDA receptors is well tolerated, but the combined blockade of both receptor types severely disrupts the respiratory function in the cat.






Foutz AS,Pierrefiche O,Denavit-Saubié M




Has Abstract


1994-01-12 00:00:00












  • Neural mechanisms of the octave illusion: electrophysiological evidence for central origin.

    abstract::The octave illusion is experienced when two simultaneous tones, separated by one octave and presented to the opposite ears, are continuously reversed between the two ears. Subjects consistently report a sequence of alternating single tones: the high tone in the right ear and the low in the left. We wished to determine...


    pub_type: 临床试验,杂志文章


    authors: Ross J,Tervaniemi M,Näätänen R

    更新日期:1996-12-20 00:00:00

  • Effects of repeated amphetamine treatment on the locomotor activity of the dopamine D1A-deficient mouse.

    abstract::The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure phase, D1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the...


    pub_type: 杂志文章


    authors: Crawford CA,Drago J,Watson JB,Levine MS

    更新日期:1997-07-28 00:00:00

  • Evidence for inert gas narcosis mechanisms in the occurrence of psychotic-like episodes at pressure environment.

    abstract::Psychotic-like episodes in divers exposed to high pressure have been attributed to either the high-pressure neurological syndrome, confinement in pressure chamber, the subject's personality, or the addition of nitrogen or hydrogen to the basic helium-oxygen breathing mixture used for deep diving. Alternatively, it is ...


    pub_type: 杂志文章


    authors: Abraini JH

    更新日期:1995-03-07 00:00:00

  • Memory-related changes of nitric oxide synthase activity and nitrite level in rat brain.

    abstract::The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, ...


    pub_type: 杂志文章


    authors: Chen J,Zhang S,Zuo P,Tang L

    更新日期:1997-05-06 00:00:00

  • CEP-1347 promotes survival of NGF responsive neurones in primary DRG explants.

    abstract::CEP-1347 inhibits the signalling pathway of c-jun-N-terminal kinase, and is neuroprotective in vivo and in vitro. Embryonic chick dorsal root ganglion neurones are dependent on NGF for survival and neurite outgrowth; NGF withdrawal results in apoptotic cell death. We examined the neuroprotective and neurite outgrowth ...


    pub_type: 杂志文章


    authors: Bilsland JG,Harper SJ

    更新日期:2003-05-23 00:00:00

  • Auditory event-related potentials as a function of abstract change magnitude.

    abstract::Event-related potentials were recorded in healthy volunteers to test the accuracy of the human brain to extract, preattentively, auditory abstract rules. The abstract rule was determined by the frequency relationship between two pure tones forming a pair. The standard pairs had identical tone frequency, whereas the de...


    pub_type: 杂志文章


    authors: Carral V,Corral MJ,Escera C

    更新日期:2005-02-28 00:00:00

  • Functional asymmetry in primary auditory cortex for processing musical sounds: temporal pattern analysis of fMRI time series.

    abstract::Hemispheric differences in the temporal processing of musical sounds within the primary auditory cortex were investigated using functional magnetic resonance imaging (fMRI) time series analysis on a 3.0 T system in right-handed individuals who had no formal training in music. The two hemispheres exhibited a clear-cut ...


    pub_type: 杂志文章


    authors: Izumi S,Itoh K,Matsuzawa H,Takahashi S,Kwee IL,Nakada T

    更新日期:2011-07-13 00:00:00

  • Acceleration of EEG theta wave precedes the phasic surge of arterial pressure during REM sleep in the rat.

    abstract::We investigated temporal relationships among EEG theta frequency, eye movement (EM) burst and phasic surge of arterial pressure (AP) during rapid eye movement (REM) sleep in six rats. Changes in EEG theta frequency, EM number, mean AP (MAP) and heart rate (HR) during 1 s bins were obtained with reference to the onset ...


    pub_type: 杂志文章


    authors: Sei H,Morita Y

    更新日期:1996-11-25 00:00:00

  • A ventral pontine pathway promotes rhythmic activity in the medulla of neonate mice.

    abstract::We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontin...


    pub_type: 杂志文章


    authors: Borday V,Kato F,Champagnat J

    更新日期:1997-12-01 00:00:00

  • Novel gene HCS1 is specifically expressed in the giant interneurones of the terrestrial snail.

    abstract::The terrestrial snail Helix lucorum is a promising model for molecular neurobiology since its central nervous system (CNS) is simple and contains many morphologically and functionally identified large neurones. Among these, the giant interneurones located in pleural and parietal ganglia are especially interesting beca...


    pub_type: 杂志文章


    authors: Bogdanov YD,Ovchinnikov DA,Balaban PM,Belyavsky AV

    更新日期:1994-01-31 00:00:00

  • Sulcogyral variation in NMDA receptor 2A/B subunit immunoreactivity in human brain.

    abstract::NMDA receptors (NR) are important in many neurological processes. Using a large series of human brain tissue, we show that the distribution of NR2A/B immunoreactivity varies according to position along a gyrus. For pyramidal neurons in laminae II and III, immunoreactivity is most marked at gyral crown and gyral lips, ...


    pub_type: 杂志文章


    authors: Sisodiya SM,Heffernan J,Harrison PJ,Squier MV,Thom M

    更新日期:2000-08-03 00:00:00

  • Sex-specific lateralization of event-related potential effects during mental rotation of polygons.

    abstract::Mental rotation performance has been found to produce one of the largest sex differences in cognition. Many theories suggest that this effect should be accompanied by a sex difference in functional cerebral asymmetry, but empirical data are more than equivocal probably because of (a) the use of inappropriate stimuli a...


    pub_type: 杂志文章


    authors: Pellkofer J,Jansen P,Heil M

    更新日期:2014-08-06 00:00:00

  • HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture.

    abstract::The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but not that produced ...


    pub_type: 杂志文章


    authors: Eshhar N,Striem S,Biegon A

    更新日期:1993-12-13 00:00:00

  • Rat hippocampus-prefrontal multiple units and synaptic efficacy in vivo.

    abstract::We recorded multiple unit activities of the CA1 region of the intermediate hippocampus and prelimbic area of the prefrontal cortex, and evoked responses in the prefrontal cortex by hippocampal stimulation in urethane-anesthetized rats. The multiple unit activities between these regions showed significant peaks of cros...


    pub_type: 杂志文章


    authors: Fujiwara SE,Akema T,Izaki Y

    更新日期:2010-10-27 00:00:00

  • Neural manifestation of cognitive and precognitive mismatch detection in early infancy.

    abstract::We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a ...


    pub_type: 杂志文章


    authors: Friederici AD,Friedrich M,Weber C

    更新日期:2002-07-19 00:00:00

  • Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity.

    abstract::Neurite outgrowth involves various molecular mechanisms generating complex brain connections. These mechanisms have been linked to plasticity and learning and are thought to be deregulated in neuropsychiatric diseases. The transcription factor REST/NRSF regulates a subset of genes encoding neurite outgrowth molecules....


    pub_type: 杂志文章


    authors: Lepagnol-Bestel AM,Maussion G,Ramoz N,Moalic JM,Gorwood P,Simonneau M

    更新日期:2007-03-26 00:00:00

  • MRI visualization of focal induced neocortical malformations of the rat.

    abstract::In an attempt to determine whether small focal malformations of the neocortex can be visualized in vivo, focal microgyria were induced in the neocortex of otherwise normal rats by freezing injury to the developing cortical plate, and in adulthood the malformation was visualized using MRI. Induced microgyria of varying...


    pub_type: 杂志文章


    authors: Rosen GD,Burstein D

    更新日期:1997-12-22 00:00:00

  • Three novel connexin26 gene mutations in autosomal recessive non-syndromic deafness.

    abstract::Since the first identification of an association between mutations in the connexin26 (Cx26) gene and autosomal recessive non-syndromic deafness it has been shown that several mutations in this gene cause recessive, sporadic, and dominant non-syndromic deafness. Three novel mutations in the Cx26 gene were identified in...


    pub_type: 杂志文章


    authors: Fuse Y,Doi K,Hasegawa T,Sugii A,Hibino H,Kubo T

    更新日期:1999-06-23 00:00:00

  • Sexual receptivity is reduced in the female mu-opioid receptor knockout mouse.

    abstract::Activation of mu-opioid receptors is critical to steroid regulation of female sexual behavior, lordosis, in rodents. Estrogen treatment activates mu-opioid receptors in the medial preoptic area inhibiting lordosis, but ultimately appears important for progesterone facilitation of lordosis. We investigated the role of ...


    pub_type: 杂志文章


    authors: Sinchak K,Shahedi K,Dewing P,Micevych P

    更新日期:2005-10-17 00:00:00

  • Role of amygdala in conditioned and unconditioned fear generated in the periaqueductal gray.

    abstract::The amygdala and ventral portion of the periaqueductal gray (vPAG) are crucial for the expression of the contextual freezing behavior. However, it is still unclear whether the amygdala also plays a role in defensive behaviors induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present st...


    pub_type: 杂志文章


    authors: Oliveira LC,Nobre MJ,Brandão ML,Landeira-Fernandez J

    更新日期:2004-10-05 00:00:00

  • Nitric oxide regulates NMDA-induced dopamine release in rat striatum.

    abstract::We investigated the effect of nitric oxide (NO) on N-methyl-D-aspartate (NMDA)-induced changes in levels of dopamine (DA) and its metabolite in the striatum using in vivo microdialysis. Local administration of 1mM NMDA into the striatum significantly augmented DA release in the striatum. Simultaneous administration of...


    pub_type: 杂志文章


    authors: Shibata M,Araki N,Ohta K,Hamada J,Shimazu K,Fukuuchi Y

    更新日期:1996-01-31 00:00:00

  • Histamine slows the onset of desensitization of rat cortical NMDA receptors.

    abstract::The effects of histamine on N-methyl-d-aspartate (NMDA) receptor-mediated ion current in cultured rat cortical neurones have been investigated by superfusion of voltage-clamped (-80 mV) cells with 100 mM NMDA and with various concentrations of histamine. In a subpopulation of the neurones tested (30/53), histamine (10...


    pub_type: 杂志文章


    authors: Zwart R,Blank T,Spiess J

    更新日期:1996-09-02 00:00:00

  • Lesion-induced right-hemispheric language and organization of nonverbal functions.

    abstract::Early left-hemispheric brain lesions may lead to a reorganization of language into the right hemisphere. Language functions are consecutively spared, but visuospatial functions show slight deficits. Cortical 'crowding' of the right hemisphere has been suggested as an explanation for this effect, but no direct evidence...


    pub_type: 杂志文章


    authors: Lidzba K,Staudt M,Wilke M,Grodd W,Krägeloh-Mann I

    更新日期:2006-06-26 00:00:00

  • Attracting attention to the illusory location of a sound: reflexive crossmodal orienting and ventriloquism.

    abstract::Sound localization can be affected by vision; in the ventriloquism effect, sounds that are hard to localize within hearing become mislocalized toward the location of concurrent visual events. Here we tested whether spatial attention is drawn to the illusory location of a ventriloquized sound. The study exploited our p...


    pub_type: 杂志文章


    authors: Spence C,Driver J

    更新日期:2000-06-26 00:00:00

  • Brainstem microstimulation activates sympathetic fibers in pudendal nerve motor branch.

    abstract::A bilateral spino-bulbo-spinal circuit conveys information from/to the male urogenital tract and perineal muscles. This is the first electrophysiological report of another descending pathway, one which conveys output from the medullary reticular formation (MRF) to activate postganglionic sympathetic fibers contained w...


    pub_type: 杂志文章


    authors: Johnson RD,Hubscher CH

    更新日期:2000-02-07 00:00:00

  • Photochemical stroke and brain-derived neurotrophic factor (BDNF) mRNA expression.

    abstract::In situ hybridization and Northern blotting were used to study the expression of brain-derived neurotrophic factor (BDNF) mRNA in the rat brain following photochemical stroke. A focal thrombotic lesion of the sensorimotor cortex was produced by intravenously injecting the light-sensitive dye rose bengal and exposing t...


    pub_type: 杂志文章


    authors: Comelli MC,Seren MS,Guidolin D,Manev RM,Favaron M,Rimland JM,Canella R,Negro A,Manev H

    更新日期:1992-06-01 00:00:00

  • Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution.

    abstract::A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the pr...


    pub_type: 杂志文章


    authors: Clemen CS,Herr C,Lie AA,Noegel AA,Schröder R

    更新日期:2001-05-08 00:00:00

  • Context-dependent representation of reinforcement in monkey amygdala.

    abstract::It has been reported that neurons in the amygdala respond to visual cues that predict reward and aversive outcomes. However, it remains unclear whether the representation of reinforcement in the amygdala depends on the relative preference for an outcome compared with another simultaneously available outcome. In this s...


    pub_type: 杂志文章


    authors: Hirai D,Hosokawa T,Inoue M,Miyachi S,Mikami A

    更新日期:2009-04-22 00:00:00

  • Inhibition of DNA synthesis in human gliomas by roscovitine.

    abstract::The early effect of 1-100 microM roscovitine, a purine analogue and cyclin-dependent kinase inhibitor, was studied on tissue specimens from eight human malignant gliomas. The tissue was incubated immediately after resection with DMEM containing [3H]methylthymidine plus vehicle alone or the proper concentration of rosc...


    pub_type: 临床试验,杂志文章


    authors: Yakisich JS,Boethius J,Lindblom IO,Wallstedt L,Vargas VI,Sidén A,Cruz MH

    更新日期:1999-08-20 00:00:00

  • Transient expression of PKC gamma mRNA in cerebellar granule cells during rat brain development.

    abstract::The localization of PKC gamma mRNA expression during the maturation of rat cerebellum has been studied by in situ hybridization. We found a transient expression over the granule cell layer and persistent high expression in the Purkinje cells during postnatal development. Expression in granule cells appeared as early a...


    pub_type: 杂志文章


    authors: Herms J,Zurmöhle U,Schlingensiepen KH,Brysch W

    更新日期:1993-07-01 00:00:00