Abstract:
:Blockade of L-type Ca2+ channels results in a decrease in firing frequency of neostriatal neurons. In contrast, N- and P/Q-types of Ca2+ channel cooperate to tune firing pattern, since both of these channel types have to be blocked to enhance firing frequency. Parameters of the intensity-frequency plot were differentially modified by Ca2+ channel antagonists: while L-type Ca2+ channel block reduced the dynamic range by about 80%, block of N- and P/Q-types of Ca2+ channel generated a steeper intensity-frequency plot. These effects are explained in terms of the sustained depolarization and the afterhyperpolarizing potential known to be dependent upon L- and N-, P/Q-types of Ca2+ channels, respectively.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Pérez-Garci E,Bargas J,Galarraga Edoi
10.1097/00001756-200307010-00013subject
Has Abstractpub_date
2003-07-01 00:00:00pages
1253-6issue
9eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830a9618
更新日期:2008-08-27 00:00:00
abstract::Voltage-gated K+ channels (K(V)) regulate cell electrical properties, proliferation, migration, and death. Rotenone is a mitochondrial inhibitor, influencing activity of many channels that potentially participate in cell death processes, but its effect on K(V) channel in neurons remains unclear. This study used whole-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830d149e
更新日期:2008-09-17 00:00:00
abstract::It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00042
更新日期:1998-08-03 00:00:00
abstract::As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00015
更新日期:2001-08-08 00:00:00
abstract::The possible role of endogenous cholinergic innervation in hippocampal plasticity is controversial. We studied the role of acetylcholine (ACh) in short- and long-term potentiation (STP and LTP), using the cholinergic neurotoxin 192 IgG-saporin. It was still possible to induce STP the LTP in the CA1 field following com...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199603220-00024
更新日期:1996-03-22 00:00:00
abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00037
更新日期:2001-07-20 00:00:00
abstract::Recently, we have generated transgenic mice (designated as SJLB) carrying human N279K mutant tau, one of the tau mutations causing parkinsonism linked to chromosome 17 (FTDP-17). SJLB mice mimic some features of behavioral alterations and neuronal pathology of patients with Alzheimer's disease. To investigate how tau ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328333b0e0
更新日期:2009-12-09 00:00:00
abstract::Inflammatory and immune responses are known to be involved in the pathogenesis of Alzheimer's disease (AD). NF-kappaB is a major transcription factor that plays a central role in the inflammatory and immune responses and is regulated by I-kappaB through an autoregulatory feedback system. Southwestern immunohistochemis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108280-00011
更新日期:2001-08-28 00:00:00
abstract::Previous studies have suggested that the dorsomedial prefrontal cortex (dmPFC) plays a central role in processing first impressions; however, little is known about how dmPFC processes different valences of first impressions. Moreover, it is still unclear as to whether the dmPFC shows lateralization or only induces dif...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000571
更新日期:2016-05-25 00:00:00
abstract::Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00005
更新日期:2001-02-12 00:00:00
abstract::Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) are assumed to provide trophic support via a target-derived, retrograde mechanism of action. However, recent studies suggest that neurotrophic factors can act in an autocrine fashion and perhaps even in an anterograde direction similar to neurotrans...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705260-00008
更新日期:1997-05-27 00:00:00
abstract::Experimental animals and patients are immobilized to allow continuous monitoring of physiological parameters. Restraint stress affects brain neurotransmitter levels and induces expression of immediate early genes. Whether immobilization stress affects outcomes in newborn animals which have suffered a hypoxic-ischaemic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00025
更新日期:1996-01-31 00:00:00
abstract::Intracerebral or intraspinal grafting of genetically modified primary fibroblasts has been shown to enhance functional recovery in several models of CNS disease, including spinal cord injury. Most of these studies utilized retrovirus vectors. In this report, we describe in vitro conditions for genetically modifying pr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199804200-00021
更新日期:1998-04-20 00:00:00
abstract::Transient global amnesia (TGA), characterised by a profound anterograde amnesia, is a model of interest to study the acquisition of novel meanings independent of episodic functioning. Three patients were tested during a TGA attack, two in the early recovery phase and the third during the acute phase of TGA, with a sem...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112040-00052
更新日期:2001-12-04 00:00:00
abstract::Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We ex...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812210-00013
更新日期:1998-12-21 00:00:00
abstract::Oleic acid, a cis-unsaturated free fatty acid, is proposed to be involved in the protein kinase C (PKC) activation pathway. Its biological actions, however, have not been well-characterized. We examined the effects of oleic acid on acetylcholine (ACh)-gated channel currents using Torpedo nicotinic ACh receptors expres...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00004
更新日期:1997-02-10 00:00:00
abstract::Chronic ethanol (EtOH) exposure can cause intracellular Ca overload by stimulating calcium channel receptors and trigger apoptosis of neurons. NCX3 may play a cytoprotective role in intracellular Ca excretion. In this study, the effect of EtOH on NCX3 was analyzed by observing NCX3 expression in the hippocampus of chr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001214
更新日期:2019-04-10 00:00:00
abstract::Neural progenitor/stem cells reside in the subventricular zone and dentate gyrus of the adult rat brain, which proliferate in response to several growth factors. Here we show that the neurospheres generated from the adult dentate gyrus and subventricular zone proliferate in vitro in response to fibroblast growth facto...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200505310-00011
更新日期:2005-05-31 00:00:00
abstract::Resident microglial cells contribute to activation and expansion of T cells under inflammatory conditions within the CNS. However, there is no evidence how interactions between microglia and T cells affect CNS inflammation. We evaluated the effect of glial cell-derived dendritic cells (GC-DC) in expanding and eliminat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200201210-00012
更新日期:2002-01-21 00:00:00
abstract::Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00045
更新日期:1996-01-31 00:00:00
abstract::Previous studies using magnetoencephalographic (MEG) recordings have revealed neuronal populations responding to discrete auditory stimuli in the supratemporal cortex of the human brain. We used the novel whole-head magnetometer (Neuromag-122) to determine whether regions outside the auditory cortex are activated by a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412300-00046
更新日期:1994-12-30 00:00:00
abstract::AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over flip in dentate gyrus,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-06-27 00:00:00
abstract::Recent studies of electroencephalogram event-related potentials reported aberrant feedback-related negativity (FRN) in neurological and psychiatric diseases, such as alcoholism and attention-deficit hyperactivity disorder. These diseases are characterized by high impulsivity. We investigated the relationship between F...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833bfd36
更新日期:2010-07-14 00:00:00
abstract::The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochrome...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199209000-00007
更新日期:1992-09-01 00:00:00
abstract::Human cognitive decisions can be strongly susceptible to the manner in which options are presented ('framing effect'). Here we investigated the neural basis of response adjustments induced by changing frames during intuitive decisions. Evidence exists that the anterior cingulate cortex plays a general role in behavior...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282202c61
更新日期:2007-07-16 00:00:00
abstract::Using functional magnetic resonance imaging, we explored the role of semantics in mediating orthographic-to-phonological processing in reading aloud, focusing on the interaction of imageability with spelling-to-sound consistency for low-frequency words. Behaviorally, high-imageable words attenuate the standard latency...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200504250-00021
更新日期:2005-04-25 00:00:00
abstract::Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00045
更新日期:1999-04-06 00:00:00
abstract:OBJECTIVE:Birdsong sounds are often used to inform visually-challenged people about the presence of basic infrastructures, and therefore need to be salient in noisy urban environments. How salient sounds are processed in the brain could inform us about the optimal birdsong in such environments. However, brain activity ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001563
更新日期:2021-01-13 00:00:00
abstract::Microinjection of neuropeptide Y (NPY) into the paraventricular nucleus (PVN) of the hypothalamus stimulates eating and increases respiratory quotient. In contrast, administration of opioid receptor antagonists reduces food intake and suppresses NPY-induced feeding. The present study examined whether naloxone methiodi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00016
更新日期:2000-03-20 00:00:00
abstract::Wilson's disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in different population. This study aimed to examine the genotypes of the ATP7B mutant alleles in WD patients from Southern China. Genomic DN...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000216
更新日期:2014-10-01 00:00:00