Abstract:
:Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monkeys. In the present study, low doses of these two drugs, which were ineffective when given alone, significantly impaired performance when given in combination. Moreover, the effect was greater than additive, indicating a synergistic interaction. These results suggest that interactions between cholinergic and glutamatergic systems play an important role in regulation of visual recognition memory.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Matsuoka N,Aigner TGdoi
10.1097/00001756-199601310-00045subject
Has Abstractpub_date
1996-01-31 00:00:00pages
565-8issue
2eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
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