Abstract:
:Using functional magnetic resonance imaging, we explored the role of semantics in mediating orthographic-to-phonological processing in reading aloud, focusing on the interaction of imageability with spelling-to-sound consistency for low-frequency words. Behaviorally, high-imageable words attenuate the standard latency and accuracy disadvantage for low-frequency inconsistent words relative to their consistent counterparts. Neurobiologically, high-imageable words reduced consistency-related activation in the inferior frontal gyrus but increased posterior activation in the angular and middle temporal gyri, representing a possible neural signature of the tradeoff between semantics and phonology in reading aloud. We discuss implications for neurobiological models of reading in terms of understanding the interplay among areas associated with component processes and suggest that the results constitute an important step toward integrating neurobiological and computational models of reading.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Frost SJ,Mencl WE,Sandak R,Moore DL,Rueckl JG,Katz L,Fulbright RK,Pugh KRdoi
10.1097/00001756-200504250-00021subject
Has Abstractpub_date
2005-04-25 00:00:00pages
621-4issue
6eissn
0959-4965issn
1473-558Xpii
00001756-200504250-00021journal_volume
16pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Metabolic hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein in CNS-type cells had an effect on mitochondria. We found abnormal mo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199901180-00008
更新日期:1999-01-18 00:00:00
abstract::Widespread invasiveness, represented by the invasion and migration, is the most important characteristic of glioblastoma multiforme (GBM) and is the main reason for therapeutic failure and recurrence of the tumor. Hypoxia is one of the main microenvironment in determining tumor invasiveness. Therefore, intense efforts...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001156
更新日期:2018-12-12 00:00:00
abstract::MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidenc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001023
更新日期:2018-06-13 00:00:00
abstract::AMPA (EC50 = 1.0 x 10(-6) M) and NMDA (EC50 = 1.3 x 10(-4) M) trigger 45Ca2+ influx in 13-day chick embryonic retinal explants. This agonist-driven cationic flux is specifically inhibited by typical competitive antagonists, such as 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 2-amino-7-phosphonoheptanoate (AP7), respec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200007140-00047
更新日期:2000-07-14 00:00:00
abstract::Clozapine is an effective atypical antipsychotic that has high affinity for serotonin type 6 receptors (5HT6). We tested the hypothesis that clinical response to clozapine in patients refractory to typical antipsychotic treatment is related to the genetic variant (C267T) of the 5HT6 receptors. Ninety-nine schizophreni...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904260-00014
更新日期:1999-04-26 00:00:00
abstract::Two well-known appetite-regulatory peptides, leptin and cocaine- and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000822
更新日期:2017-08-02 00:00:00
abstract::Optic nerves of adult rats were crushed 2 mm behind the eye to examine the ability of retinal ganglion cells (RGCs) to regenerate their axons. Some animals were treated with the immunophilin ligands FK 506 or GPI 1046 for up to 4 weeks. After 10 days to 16 months, regenerating RGC axons were visualized using anterogra...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199912160-00042
更新日期:1999-12-16 00:00:00
abstract::As treatment of ischemic stroke remains a challenge with respect to the failure of numerous neuroprotective attempts, there is an ongoing need for better understanding of pathophysiological mechanisms causing tissue damage. Although ischemic outcomes have been studied extensively at the cellular and molecular level us...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000395
更新日期:2015-07-08 00:00:00
abstract::Recent studies have discussed the role of the cerebellum in not only motor but also cognitive functions, and in particular, fronto-executive operations. Similar to a previous study on hemineglect patients, we recorded eye movements during a visual search task to investigate patients with isolated infarction of the cer...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000177015.75096.b6
更新日期:2005-09-08 00:00:00
abstract::The aim of this investigation was to study whether melatonin affects the release of oxytocin and vasopressin by the pituitary neurointermediate lobe of the Syrian hamster in vitro. The effect of melatonin was studied on the unstimulated (pre- and post-K+ -stimulated) release of oxytocin and vasopressin and on the resp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199512150-00004
更新日期:1995-12-15 00:00:00
abstract::Axotomy-induced death of corticospinal neurons (CSN) is prevented by intracotrical infusions of BDNF or NT-3 within the first week after axotomy. The present study examined whether this represents merely a delay of CSN death or whether BDNF and NT-3 can promote long-term survival of these neurons in vivo. The neurotro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908200-00043
更新日期:1999-08-20 00:00:00
abstract::With the purpose of elucidating the functional fields involved in the discrimination of visual form based either on luminance or binocular disparity cues, we used PET to measure changes in regional cerebral blood flow (rCBF) in ten volunteers while they performed visual discrimination tasks. The averaged standardized ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199411000-00039
更新日期:1994-11-21 00:00:00
abstract::The regulation of glucocorticoid receptors and nuclear factor kappaB was evaluated in the spiral ganglion neurons after 4 h of restraint stress in the mouse cochlea. Immediately after restraint stress, glucocorticoid receptor protein expression was not altered in spiral ganglion neurons even though both the plasma cor...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000220131.24468.e7
更新日期:2006-06-26 00:00:00
abstract::The temporal lobe regions involved in memory retrieval were examined using fMRI. During an associative recognition test, participants made memory judgments about the study color of previously presented drawings of objects, and during item recognition tests they made old/new judgments about previously studied objects o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00035
更新日期:2001-02-12 00:00:00
abstract::Diabetic peripheral neuropathy is the most common complication of diabetes mellitus and leads to sensory symptoms, including diabetic neuropathic pain (DNP). DNP is a major public health problem because it has a considerable impact on life quality of diabetes mellitus patients. Therefore, development of novel effectiv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001138
更新日期:2018-12-05 00:00:00
abstract::Astrogliosis is an important component of the response to injury of the central nervous system (CNS). The Id family of helix-loop-helix (HLH) transcription factors has been implicated in the regulation of cellular differentiation in several different lineages and may contribute to the regulation of astrogliosis. We ex...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199812210-00013
更新日期:1998-12-21 00:00:00
abstract::Correcting for eddy currents, movement-induced distortion and gradient inhomogeneities is imperative when processing diffusion MRI (dMRI) data, but is highly computing resource-intensive. Recently, Compute Unified Device Architecture (CUDA) was implemented for the widely-used eddy-correction software, 'eddy', which re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001475
更新日期:2020-07-10 00:00:00
abstract::Nitric oxide (NO), a free radical gas that acts as a neural messenger, is produced from L-arginine by the enzyme nitric oxide synthase (NOS). The present study describes the autoradiographic localization throughout rat brain of the binding of [3H]L-NG-nitro-arginine ([3H]L-NOARG), a reversible NOS inhibitor, and confi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199510020-00005
更新日期:1995-10-02 00:00:00
abstract::Neural salient serine/arginine-rich protein 1 (NSSR1) expression has been found in mouse cerebral neurons, cerebellar Purkinje cells, pyramidal neurons and granule cells of dentate gyrus and regulates the pre-mRNA splicing of genes important for neural functions. In this study, we demonstrated that NSSR1 is expressed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f0b542
更新日期:2007-10-29 00:00:00
abstract::We examined the biology of AMPA/kainate-induced motor neuron degeneration using dissociated spinal cord cultures and motor neuron-specific antibodies which enable characterization of individual motor neurons in culture. Cobalt, which is thought to pass through Ca2+-permeable AMPA/kainate receptors following kainate ex...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199903170-00034
更新日期:1999-03-17 00:00:00
abstract::Skin sensory nerve nocifensor functions were investigated non-invasively in rats by measuring neurogenic inflammation and blister healing-rate after unilateral hindlimb denervation. Axon reflexes were evoked by transdermal iontophoresis of acetylcholine (ACh) or noxious electrical stimulation (TNS). Sodium nitroprussi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199305000-00001
更新日期:1993-05-01 00:00:00
abstract::We reported differential expression of the transient receptor potential vanilloid 1 (TRPV1), the transient receptor potential ankyrin 1 (TRPA1), and the (TRPM8) in the geniculate ganglions (GGs) of naive rats. In medical practice, the chorda tympani nerve (CTN) is injured in some patients during middle-ear surgery, an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000436
更新日期:2015-09-30 00:00:00
abstract::Thyroid hormones, which play an important role in the development and regeneration of the nervous system, require the presence of specific nuclear T3 receptors (NT3R). In this study we provide evidence that NT3R expression by Schwann cells was up-regulated in response to a loss of axonal contact in vitro and in vivo. ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199311180-00010
更新日期:1993-11-18 00:00:00
abstract::In a previous event-related fMRI study, we showed that the left occipitotemporal cortex was specifically involved in the abstract categorization of visually presented alphabetic symbols. Here, we duplicate the fMRI study by measuring visual event-related potentials to verify whether the left posterior cortex supports ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200206120-00008
更新日期:2002-06-12 00:00:00
abstract::Previous studies have shown that isosteviol sodium (STVNa) protects against permanent cerebral ischemia injury by inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated inflammatory responses. Overwhelming evidence shows that toll-like receptors (TLRs) are the upstream regula...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001033
更新日期:2018-07-04 00:00:00
abstract::Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00005
更新日期:2001-02-12 00:00:00
abstract::The first step in olfactory transduction is the recognition of odor molecules by membrane bound receptors belonging to the superfamily of G-protein coupled receptors; other members of this family are involved in neurotransmission. Based on the considerable homology between individual members of this family, we have in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199208000-00001
更新日期:1992-08-01 00:00:00
abstract::The effects of a pharmacological blockade of the periaqueductal grey of the midbrain (PAG) on the elicitability of vocal fold movements from the facial motor cortex on the one hand and the anterior cingulate cortex and dorsomedial hypothalamus on the other were studied in the squirrel monkey. PAG blockade abolished vo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611250-00023
更新日期:1996-11-25 00:00:00
abstract::We used isolated IgG antibodies selective for P2X3 receptors to study the ultrastructural distribution of these receptors in rat sensory neurons. In trigeminal ganglia, P2X3 receptor immunoreactivity occurred in small and large nerve cell bodies and their processes. Endoplasmic reticulum and Golgi apparatus were heavi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808030-00022
更新日期:1998-08-03 00:00:00
abstract::The parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridine (MPP+) acts through inhibition of complex I of the electron transport chain. Recent evidence suggests that it may also act through inhibition of 2-ketoglutarate dehydrogenase complex (KDHC). We confirmed this observation in isolated rat liver mitochondria ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199808240-00018
更新日期:1998-08-24 00:00:00