Hypoxia enhances the migration and invasion of human glioblastoma U87 cells through PI3K/Akt/mTOR/HIF-1α pathway.

abstract：:We examined the neural correlates associated with a short gap between two identical pure tones (within-channel) and between two different tones (between-channel) in an odd-ball paradigm. Gap durations were selected such that a gap between identical tones was as discriminable as a gap between two different tones. Spati...

journal_title：Neuroreport

authors： Heinrich A,Alain C,Schneider BA

更新日期：2004-09-15 00:00:00

abstract：:It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-...

journal_title：Neuroreport

authors： Li A,Lao L,Wang Y,Zhang H,Ren K,Berman BM,Zhang R

更新日期：2007-03-26 00:00:00

abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis and impairment of the central corticotropin-releasing factor system are factors in the pathogenesis of depression. Though several antagonists of the corticotropin-releasing factor 1 receptor were effective in the recognized behavioral tests for antidepressant ac...

journal_title：Neuroreport

authors： Wang XB,Zhang YQ,Xue RR,Yang ZZ,Zhang XF

更新日期：2020-01-08 00:00:00

abstract：:We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[F]fluoro-2-deo...

journal_title：Neuroreport

authors： Watanabe N,Ishii K,Hotta H,Oda K,Sakata M,Toyohara J,Ishiwata K

更新日期：2013-05-29 00:00:00

abstract：:Voltage-gated sodium channels consist of a pore-containing alpha-subunit and one or more auxiliary beta-subunits, which may modulate channel function. We previously demonstrated that sodium channel SNS/PN3 alpha-subunits were decreased in human sensory cell bodies after spinal root avulsion injury, and accumulated at ...

journal_title：Neuroreport

authors： Coward K,Jowett A,Plumpton C,Powell A,Birch R,Tate S,Bountra C,Anand P

更新日期：2001-03-05 00:00:00

abstract：:Administration of either a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801 (dizocilpine), or a muscarinic antagonist, scopolamine, produces dose-related impairments in performance of a visual recognition memory task, delayed non-matching to sample (DNMS) with lists of 20 symbols, in rhesus monk...

journal_title：Neuroreport

authors： Matsuoka N,Aigner TG

更新日期：1996-01-31 00:00:00

abstract：:GABAA receptor-independent effects of benzodiazepine receptor (BZ-R) agonists on calcium and barium spikes were recorded intracellularly in the presence of bicuculline from CA3 hippocampal cells of young and adult rats. Zolpidem (omega 1 BZ-R agonist), had no effects in young animals but decreased calcium and barium s...

journal_title：Neuroreport

authors： Rovira C,Ben-Ari Y

更新日期：1994-10-27 00:00:00

abstract：:Calpain activation has been implicated in the pathogenesis of Alzheimer's disease. Okadaic acid, a protein phosphatase-2A inhibitor, has been used in Alzheimer's disease research models to increase tau phosphorylation and induce neuronal death. We previously reported that okadaic acid induced predominant activation of...

journal_title：Neuroreport

authors： Yoon S,Choi J,Huh JW,Hwang O,Kim D

更新日期：2006-05-15 00:00:00

abstract：:Astrocytes induce blood-brain barrier (BBB) properties in brain endothelial cells (EC)*O(2)*, generated in blood and EC, opens the BBB. Hence, high activity of superoxide dismutase (SOD) is a prerequisite for normal BBB function. Therefore, the influence of rat astrocytes on the expression of manganese (Mn)SOD in rat ...

journal_title：Neuroreport

authors： Schroeter ML,Müller S,Lindenau J,Wiesner B,Hanisch UK,Wolf G,Blasig IE

更新日期：2001-08-08 00:00:00

abstract：:The study aimed to compare the whole-brain gray matter volume (GMV) and white matter volume (WMV) difference between primary angle closure glaucoma (PACG) patients and health controls (HCs) using a voxel-based morphometry method. A total of 27 patients with PACG (17 males and 10 females) and 27 HCs (17 males and 10 fe...

journal_title：Neuroreport

authors： Jiang F,Zeng FF,Yu C,Ye YQ,Zeng XJ

更新日期：2018-11-07 00:00:00

abstract：:The aim of this study was to identify age-related changes of P300 peak amplitude and P300 latency between closely separated nonsenile age groups (late young-aged adults and early middle-aged adults) and to investigate whether or not P300 has the potential to be used as a measure of cognitive aging even among nonsenile...

journal_title：Neuroreport

authors： Bourisly AK

更新日期：2016-09-28 00:00:00

abstract：:Dopamine (DA) deficiency in Parkinson's disease is commonly treated with L-dihydroxyphenylalanine (L-dopa), the amino acid precursor to DA. L-dopa is neurotoxic in vitro and impairs survival of metabolically stressed neurons in vivo. We examined with microdialysis of substantia nigra in awake rats the local production...

journal_title：Neuroreport

authors： Smith TS,Parker WD Jr,Bennett JP Jr

更新日期：1994-04-14 00:00:00

abstract：:Upon perfusion with Mg2+-free artificial cerebrospinal fluid (ACSF) organotypic hippocampal slice cultures develop seizure-like events and tonic recurrent discharges in which areas CA3 and CA1 and, in contrast to acute slices, also the dentate gyrus (DG) participate. Using the fluorescent dye propidium iodide (PI) we ...

journal_title：Neuroreport

authors： Kovács R,Gutiérrez R,Kivi A,Schuchmann S,Gabriel S,Heinemann U

更新日期：1999-02-05 00:00:00

abstract：:The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 an...

journal_title：Neuroreport

authors： Tellam DJ,Perone MJ,Dunn IC,Radovick S,Brennand J,Rivier JE,Castro MG,Lovejoy DA

更新日期：1998-10-05 00:00:00

abstract：:The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...

journal_title：Neuroreport

authors： Yamada K,Sakai K,Akazawa K,Yuen S,Sugimoto N,Sasajima H,Mineura K,Nishimura T

更新日期：2010-09-15 00:00:00

abstract：:Autophosphorylation of the alpha-isoform of Ca2+/calmodulin-dependent kinase II switches the kinase into an autonomous activity mode. This molecular switch is important for hippocampal long-term memory formation, which requires de novo gene transcription and protein synthesis. Here, we have studied whether auto-phosph...

journal_title：Neuroreport

authors： von Hertzen LS,Giese KP

更新日期：2005-08-22 00:00:00

abstract：:ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolo...

journal_title：Neuroreport

authors： Yu Y,Matsuyama Y,Nakashima S,Yanase M,Kiuchi K,Ishiguro N

更新日期：2004-09-15 00:00:00

abstract：:Neuronal network reconstruction is a pivotal determinant for functional recovery after spinal cord injury (SCI), the process of which includes synaptogenesis. Slit2 protein has been identified as a key regulator of axon regeneration and synapse formation in the vertebrate. Meanwhile, RhoA is the converging cascade of ...

journal_title：Neuroreport

authors： Li Y,Gao Y,Xu X,Shi R,Liu J,Yao W,Ke C

更新日期：2017-01-18 00:00:00

abstract：:The NMDA receptor is one of the ionotropic glutamate receptors essential for excitatory neurotransmission. The NMDAR1 subunit is inactivated by direct interaction with calmodulin. The protein levels of calmodulin, NMDAR1 and their complex were quantified in tissue resected from epileptogenic and non-epileptogenic cort...

journal_title：Neuroreport

authors： Mikuni N,Nishiyama K,Babb TL,Ying Z,Najm I,Okamoto T,Lüders HO,Wylie C

更新日期：1999-05-14 00:00:00

abstract：OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...

journal_title：Neuroreport

authors： Wang J,Lu X,Zheng K,Jing L

更新日期：2021-01-18 00:00:00

abstract：:Levels of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were quantified in the rat striatum and cerebral cortex following single injections of the non-competitive NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors o...

journal_title：Neuroreport

authors： Laprade N,Soghomonian JJ

更新日期：1995-10-02 00:00:00

abstract：:Recently, it has been shown that visual perception can be radically altered by signals of other modalities. For example, when a single flash is accompanied by multiple auditory beeps, it is often perceived as multiple flashes. This effect is known as the sound-induced flash illusion. In order to investigate the princi...

journal_title：Neuroreport

authors： Shams L,Ma WJ,Beierholm U

更新日期：2005-11-28 00:00:00

abstract：:We tested the hypothesis that in a cluttered visual scene, the magnocellular (M) pathway is crucial for focusing attention serially on the objects in the field. Since developmental dyslexia is commonly associated with an M pathway deficit, we compared reading impaired children and age-matched normal readers in a searc...

journal_title：Neuroreport

authors： Vidyasagar TR,Pammer K

更新日期：1999-04-26 00:00:00

abstract：:Somatosensory evoked fields were recorded to determine the effects of movement and attention on high-frequency oscillations during active finger movements of the ipsilateral and contralateral sides in response to electrical stimulation of the median nerve. A whole-scalp neuromagnetometer was used to record somatosenso...

journal_title：Neuroreport

authors： Inoue K,Harada T,Kaseda Y,Mimori Y,Hashizume A,Hashimoto I,Matsumoto M

更新日期：2002-10-28 00:00:00

abstract：:We determined whether acute compensatory feeding pattern changes after bulbectomy persist on a chronic basis, or whether physiological adaptation occurs to normalize acute changes. Rats were randomized to olfactory bulbectomy or sham operation; all had jugular vein catheterization. Food intake, meal number and size we...

journal_title：Neuroreport

authors： Meguid MM,Koseki M,Yang ZJ,Gleason JR,Laviano A

更新日期：1997-04-14 00:00:00

abstract：:The present study examined the distribution in the human spinal cord of a unique carboxy terminus sequence contained within MOR-1C, one of the recently described splice variants of the cloned mu opioid receptor gene MOR-1. Although MOR-1-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were o...

journal_title：Neuroreport

authors： Abbadie C,Gultekin SH,Pasternak GW

更新日期：2000-06-26 00:00:00

abstract：:In this study we investigated the utility of different MRI techniques for the detection and predictability of hemorrhagic transformation (HT) in a rat model of transient focal cerebral ischemia. Hemorrhagic infarction was reliably identified with gradient-echo sequences and developed between 2 and 7 days following the...

journal_title：Neuroreport

authors： Neumann-Haefelin T,Kastrup A,de Crespigny A,Ringer TM,Sun GH,Yenari MA,Moseley ME

更新日期：2001-02-12 00:00:00

abstract：:This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...

journal_title：Neuroreport

authors： Schaefer M,Heinze HJ,Rotte M

更新日期：2008-06-11 00:00:00

abstract：:The serotonin transporter is a strong candidate for aetiological involvement in affective disorders and psychosis. We analysed a VNTR in intron 2 of the human serotonin transporter gene (hSERT) for allelic association with bipolar affective disorder, unipolar depression and schizophrenia. An increased frequency of all...

journal_title：Neuroreport

authors： Collier DA,Arranz MJ,Sham P,Battersby S,Vallada H,Gill P,Aitchison KJ,Sodhi M,Li T,Roberts GW,Smith B,Morton J,Murray RM,Smith D,Kirov G

更新日期：1996-07-08 00:00:00

abstract：:Wilson's disease (WD) is an autosomal recessive inheritance disorder of copper metabolism due to mutations in the ATP7B gene. The distribution of ATP7B gene mutations is diverse in different population. This study aimed to examine the genotypes of the ATP7B mutant alleles in WD patients from Southern China. Genomic DN...

journal_title：Neuroreport

authors： Wei Z,Huang Y,Liu A,Diao S,Yu Q,Peng Z,Hong M

更新日期：2014-10-01 00:00:00