Alpha-isoform of Ca2+/calmodulin-dependent kinase II autophosphorylation is required for memory consolidation-specific transcription.

abstract：:Deficits in processing of auditory stimuli are known to play an important role in the aetiology of dyslexia. To specify the auditory deficit in children at risk for dyslexia, 19 children with a phonological deficit and 15 controls were tested using the mismatch negativity event-related potential, which reflects preatt...

journal_title：Neuroreport

authors： Bitz U,Gust K,Spitzer M,Kiefer M

更新日期：2007-06-11 00:00:00

abstract：:An anti-leptin polyclonal antiserum was used to detect leptin-immunoreactivity (-ir) in the central nervous system in rats. Leptin-ir was found in perikaryon and processes of neurons in the hypothalamus, including the paraventricular nucleus, and in several regions in the brainstem, including the nucleus of the solita...

journal_title：Neuroreport

authors： Li HY,Wang LL,Yeh RS

更新日期：1999-02-05 00:00:00

abstract：:Microglial activation is a prominent feature of affected brain areas in multiple system atrophy. Microglia express proinflammatory peptides, which may be a result of activation of nuclear factor-KB. We investigated the nuclear presence of RelA, the 65 kDa subunit of the NF-KB/RelA family in striatum and brain stem of ...

journal_title：Neuroreport

authors： Schwarz SC,Seufferlein T,Liptay S,Schmid RM,Kasischke K,Foster OJ,Daniel S,Schwarz J

更新日期：1998-09-14 00:00:00

abstract：:In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...

journal_title：Neuroreport

authors： Craner MJ,Klein JP,Black JA,Waxman SG

更新日期：2002-09-16 00:00:00

abstract：:The hippocampus is well known to contribute to episodic memory encoding. Here we used functional magnetic resonance imaging to investigate the hippocampal response to exponentially varying encoding demands while forming associations between faces and names. We found that only the left hippocampus exhibited a stepped m...

journal_title：Neuroreport

authors： Ulrich M,Jonas C,Grön G

更新日期：2010-01-06 00:00:00

abstract：:The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippoc...

journal_title：Neuroreport

authors： Meyers RA,Zavala AR,Neisewander JL

更新日期：2003-11-14 00:00:00

abstract：:Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury. Recent evidence has also suggested the critical role of an epigenetic mechanism in ...

journal_title：Neuroreport

authors： Li K,Zhao GQ,Li LY,Wu GZ,Cui SS

更新日期：2014-10-01 00:00:00

abstract：:Animal studies have shown brain ischaemia to cause oxidative damage to DNA and activation of caspase-3, leading to apoptosis. These changes may be exacerbated by reperfusion. To assess caspase-3 activation after transient and permanent brain ischaemia in man, we examined brain tissue from patients who had experienced ...

journal_title：Neuroreport

authors： Love S,Barber R,Srinivasan A,Wilcock GK

更新日期：2000-08-03 00:00:00

abstract：:The present study explored duration mismatch negativity (MMN) reduction in schizophrenia. Duration MMN studies usually employ tones of very short duration (< 200 ms). For stimuli < 200 ms in duration, an increment in duration is accompanied by an increase in perceived loudness. It was previously proposed that the effe...

journal_title：Neuroreport

authors： Todd J,Michie PT,Jablensky AV

更新日期：2001-12-21 00:00:00

abstract：:This study investigated the functional neuroanatomy involved in retrieval of structured versus unstructured verbal information. We compared cerebral blood flow using PET with the [15O]water method while subjects engaged in recall of novel and practised narratives and lists of unrelated words. Left orbital frontal cort...

journal_title：Neuroreport

authors： Paradiso S,Crespo Facorro B,Andreasen NC,O'Leary DS,Watkins LG,Boles Ponto L,Hichwa RD

更新日期：1997-09-29 00:00:00

abstract：:During the development of central nervous system, radial glial cells support target-specific neuronal migration. We recently reported that after implantation of chitosan channels with complete spinal cord transection, the tissue bridging the spinal cord stumps contained axons and radial glial cells. The purpose of thi...

journal_title：Neuroreport

authors： Nomura H,Kim H,Mothe A,Zahir T,Kulbatski I,Morshead CM,Shoichet MS,Tator CH

更新日期：2010-09-15 00:00:00

abstract：:Predicting neuron death or survival after axonal injury is important in neurotrauma research. We now used in vivo confocal neuroimaging microscopy to repeatedly visualize retinal ganglion cells after optic nerve crush and studied their morphological alterations and ultimate fate. An intracollicular injection of a retr...

journal_title：Neuroreport

authors： Rousseau V,Engelmann R,Sabel BA

更新日期：1999-11-08 00:00:00

abstract：:Previous functional neuroimaging studies of attention have emphasized the visual modality. We developed an auditory version of the continuous performance test (CPT) that included simple, focused and divided attention conditions. Positron emission tomographic (PET) scans were acquired during CPT performance in normal y...

journal_title：Neuroreport

authors： Benedict RH,Lockwood AH,Shucard JL,Shucard DW,Wack D,Murphy BW

更新日期：1998-01-05 00:00:00

abstract：:We investigated the effect of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine on eyeblink conditioning in glutamate receptor subunit 62 null mice, which have severe impairments in cerebellar long-term depression (LTD). Mice were injected intraperitoneally with scopolamine (0.5 mg/kg) or saline, an...

journal_title：Neuroreport

authors： Takatsuki K,Kawahara S,Mori H,Mishina M,Kirino Y

更新日期：2002-01-21 00:00:00

abstract：:The neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Recently it has been reported that the entire coding region of VAChT mRNA is located in the first intron of the ChAT gene. In this study, ChAT...

journal_title：Neuroreport

authors： Misawa H,Takahashi R,Deguchi T

更新日期：1995-05-09 00:00:00

abstract：:Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...

journal_title：Neuroreport

authors： Suzuki K,Okuda J,Otsuka Y,Sugawara A,Hatanaka K,Nakasato N,Kanno A,Yoshimoto T,Fujii T,Yamadori A

更新日期：2001-02-12 00:00:00

abstract：:Five patients with left visual neglect after right hemisphere lesions were examined with a line bisection and a reading task under five different conditions: head and trunk straight ahead, head or trunk oriented 20 degrees to the left and head or trunk oriented 20 degrees to the right. Fixation was always straight ahe...

journal_title：Neuroreport

authors： Schindler I,Kerkhoff G

更新日期：1997-08-18 00:00:00

abstract：:This study was designed to clarify the neuroprotective effects of tanshinone IIA (TSA) following cerebral ischemic insult. Adult Sprague-Dawley rats were operated upon to achieve a middle cerebral artery occlusion to cause transient focal cerebral ischemia, which were then randomly divided into the sham-operated contr...

journal_title：Neuroreport

authors： Wen PY,Li J,Lu BL,Liu J,Yang FZ,Zhou L,Luo H,Li WW,Zhou J

更新日期：2016-04-13 00:00:00

abstract：:Net-like structures surrounding several types of neurones contain glycoconjugates which are detectable by lectins specific for N-acetylgalactosamine. Wisteria floribunda agglutinin (WFA) was introduced as a further marker for the visualization of such perineuronal nets, which were also revealed in regions of the rat b...

journal_title：Neuroreport

authors： Härtig W,Brauer K,Brückner G

更新日期：1992-10-01 00:00:00

abstract：:Peripheral sensorineural hearing loss is a very common inner ear disorder affecting nearly 10% of the population. At present there is no cure for this disorder but gene therapy has been suggested as a potentially effective method for clinical treatment in the future. Thus we investigated the effectiveness of adenovira...

journal_title：Neuroreport

authors： Li Duan M,Bordet T,Mezzina M,Kahn A,Ulfendahl M

更新日期：2002-07-19 00:00:00

abstract：:Myristoylated alanine-rich C kinase substrate (MARCKS), an acidic protein associated with cell motility and phagocytosis, is activated upon phosphorylation by protein kinase C (PKC) and proline-directed protein kinases. In Alzheimer disease (AD), activated microglia expressing MARCKS migrates around senile plaques. We...

journal_title：Neuroreport

authors： Hasegawa H,Nakai M,Tanimukai S,Taniguchi T,Terashima A,Kawamata T,Fukunaga K,Miyamoto E,Misaki K,Mukai H,Tanaka C

更新日期：2001-08-08 00:00:00

abstract：:Selective degeneration of hypothalamic orexin neurons, a hallmark of pathology in narcolepsy patients, is in part reproduced in hypothalamic slice cultures by application of an endogenous excitotoxin quinolinic acid. Depolarized membrane potential may be responsible for the vulnerability of orexin neurons to excitotox...

journal_title：Neuroreport

authors： Katsuki H,Akaike A

更新日期：2005-08-01 00:00:00

abstract：:Demyelinated CNS axons can be remyelinated by Schwann cells. A recent study concluded that with time Schwann cell remyelination is replaced by oligodendrocyte remyelination [9]. To examine this, the extent of Schwann cell and oligodendrocyte remyelination at 4, 6.5 and 24 weeks was determined for ethidium bromide lesi...

journal_title：Neuroreport

authors： Gilson JM,Blakemore WF

更新日期：2002-07-02 00:00:00

abstract：:The role of dopamine D1A receptors in mediating amphetamine-induced sensitization was investigated using the D1A-deficient mouse. During the drug pre-exposure phase, D1A-deficient and control mice were injected for five consecutive days with saline or amphetamine (2 mg/kg, i.p.). Locomotor activity was measured on the...

journal_title：Neuroreport

authors： Crawford CA,Drago J,Watson JB,Levine MS

更新日期：1997-07-28 00:00:00

abstract：:Retinal on-bipolar cells possess specialized glutamate receptors which are coupled via a G-protein to the control of a cyclic GMP (cGMP) cascade. Whole-cell voltage clamp recordings were obtained from light-responsive on-bipolar cells in retinal slices of the dogfish. Inclusion of nitroprusside in the patch-pipette so...

journal_title：Neuroreport

authors： Shiells R,Falk G

更新日期：1992-10-01 00:00:00

abstract：:Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injur...

journal_title：Neuroreport

authors： Barmashenko G,Eysel UT,Mittmann T

更新日期：2001-10-08 00:00:00

abstract：:The steady-state visual evoked potential (SSVEP) is a powerful tool to study basic perceptual functions in the human electroencephalogram (EEG) (e.g. selective attention). The present study aimed at finding support for the SSVEP's sensitivity to higher cognitive functions (e.g. memory). We tagged pictures of meaningle...

journal_title：Neuroreport

authors： Martens U,Gert AL,Gruber T

更新日期：2012-04-18 00:00:00

abstract：:Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from withi...

journal_title：Neuroreport

authors： Vannucci M,Dietl T,Pezer N,Viggiano MP,Helmstaedter C,Schaller C,Elger CE,Grunwald T

更新日期：2003-08-06 00:00:00

abstract：:Regional brain activity associated with intentional and incidental memory retrieval was studied with PET. Previously studied and new words were presented in either an intentional or an incidental memory task. Type of task was crossed with an encoding manipulation ('deep' vs 'shallow') which varied the probability that...

journal_title：Neuroreport

authors： Rugg MD,Fletcher PC,Frith CD,Frackowiak RS,Dolan RJ

更新日期：1997-03-24 00:00:00

abstract：:The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrP, an abnormal form of the host prion protein PrP, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease ...

journal_title：Neuroreport

authors： O'Rourke KI,Spraker TR,Zhuang D,Greenlee JJ,Gidlewski TE,Hamir AN

更新日期：2007-12-03 00:00:00