Abstract:
:The environment in which cocaine is experienced becomes associated with the effects of the drug and can then elicit cocaine craving. This study examined whether the hippocampus is involved in such associations using the conditioned place preference model. Rats received bilateral lesions of the dorsal or ventral hippocampus and were then conditioned to associate a particular environment with cocaine. Following conditioning, rats with lesions of the dorsal, but not ventral, hippocampus failed to demonstrate conditioned place preference for the cocaine-associated environment. These findings suggest that the dorsal hippocampus plays a role in the association of environmental stimuli with the effects of cocaine and may have important implications for understanding craving elicited by cocaine-conditioned stimuli.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Meyers RA,Zavala AR,Neisewander JLdoi
10.1097/00001756-200311140-00023subject
Has Abstractpub_date
2003-11-14 00:00:00pages
2127-31issue
16eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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