Intracellular calcium signals in the surround of rat visual cortex lesions.

Abstract:

:Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injuries. We investigated the intracellular calcium concentration [Ca2+]i in neurons of the visual cortex using fluorescence imaging of fura-2 signals in a slice preparation obtained from lesioned and sham-operated cortices. We observed an increase in resting and stimulus evoked [Ca2+]i in the surround of the lesion, which were mediated by NMDA and non-NMDA ionotropic glutamate receptors. This increase in [Ca2+]i might be an important factor for lesion-induced functional reorganization in the rat visual cortex.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Barmashenko G,Eysel UT,Mittmann T

doi

10.1097/00001756-200110080-00009

subject

Has Abstract

pub_date

2001-10-08 00:00:00

pages

3023-8

issue

14

eissn

0959-4965

issn

1473-558X

journal_volume

12

pub_type

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