Abstract:
:Focal lesions of the visual cortex induce deafferentiation, excitotoxic cell death as well as functional reorganization in the surrounding tissue. The intracellular second messenger calcium is involved in a wide range of cellular responses including excitotoxicity and functional reorganization following cortical injuries. We investigated the intracellular calcium concentration [Ca2+]i in neurons of the visual cortex using fluorescence imaging of fura-2 signals in a slice preparation obtained from lesioned and sham-operated cortices. We observed an increase in resting and stimulus evoked [Ca2+]i in the surround of the lesion, which were mediated by NMDA and non-NMDA ionotropic glutamate receptors. This increase in [Ca2+]i might be an important factor for lesion-induced functional reorganization in the rat visual cortex.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Barmashenko G,Eysel UT,Mittmann Tdoi
10.1097/00001756-200110080-00009subject
Has Abstractpub_date
2001-10-08 00:00:00pages
3023-8issue
14eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
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