Abstract:
:We determined whether acute compensatory feeding pattern changes after bulbectomy persist on a chronic basis, or whether physiological adaptation occurs to normalize acute changes. Rats were randomized to olfactory bulbectomy or sham operation; all had jugular vein catheterization. Food intake, meal number and size were studied during infusion of parenteral nutrients providing 100% daily caloric intake (PN-100) to minimize post-ingestive effects. Rats were randomly assigned to acute (from day 14 after operation, PN-100 infused for 4 days, followed by 4 days of saline infusion) or chronic study (PN-100 infused for 4 days from day 40, followed by 4 days of saline infusion). After olfactory ablation, acutely decreased meal size was offset by increased meal number, but 40 days after, baseline differences between meal size and number no longer existed. No qualitative differences in response to PN-100 were noted between acute and chronic groups. Findings suggest a functional adaptation of food intake regulatory mechanism between 14 and 40 days after bulbectomy.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Meguid MM,Koseki M,Yang ZJ,Gleason JR,Laviano Adoi
10.1097/00001756-199704140-00023subject
Has Abstractpub_date
1997-04-14 00:00:00pages
1439-44issue
6eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Diffuse axonal injury (DAI) accounts for more than 50% of all traumatic brain injury. In response to the mechanical damage associated with DAI, the abnormal proteins produced in the neurons and axons, namely, β-APP and p-tau, induce endoplasmic reticulum (ER) stress. Curcumin, a major component extracted from the rhiz...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001015
更新日期:2018-05-23 00:00:00
abstract::The restriction of herpes virus latency to mammalian sensory ganglia has led to a search for tissue-specific regulatory molecules in these neurons which alter viral gene expression. Based primarily on work in sensory-related cell lines, several prior reports have suggested that the POU-domain transcription factor Oct-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611250-00003
更新日期:1996-11-25 00:00:00
abstract::A previous investigation has suggested that the hyperpolarization-activated cation current Ih does not contribute to the spontaneous firing of midbrain dopaminergic neurons. This conclusion was reached using Cs(-1). We have re-examined this question with extracellular recordings in slices using the more specific block...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00015
更新日期:2001-02-12 00:00:00
abstract::During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this i...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200312020-00006
更新日期:2003-12-02 00:00:00
abstract::EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001047
更新日期:2018-08-01 00:00:00
abstract::The inward rectifier Kir4.1, composed of KCNJ10 K channel subunits, plays an essential role in inner ear K homeostasis. We have investigated the developmental expression and localization of KCNJ10 (Kir4.1) in the guinea pig inner ear using semi-quantitative reverse transcription polymerase chain reaction and immunohis...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000208999.25234.91
更新日期:2006-04-03 00:00:00
abstract::Dopamine (DA) deficiency in Parkinson's disease is commonly treated with L-dihydroxyphenylalanine (L-dopa), the amino acid precursor to DA. L-dopa is neurotoxic in vitro and impairs survival of metabolically stressed neurons in vivo. We examined with microdialysis of substantia nigra in awake rats the local production...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199404000-00039
更新日期:1994-04-14 00:00:00
abstract::Salidroside (SDS), a phenylpropanoid glycoside isolated from Rhodiola rosea L., has been reported to be neuroprotective in vitro, which raises the possibility of using SDS as a neuroprotective agent after nerve injuries. In the present study, the possibly beneficial effect of SDS on promoting nerve regeneration after ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835eb867
更新日期:2013-03-27 00:00:00
abstract::Using quantitative autoradiography, the present study examined ionotropic glutamatergic receptor binding sites using [3H]dizocilpine, [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate, and [3H]kainate in the posterior cingulate cortex of schizophrenia patients and matched controls. We found a significant increa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000174056.11403.71
更新日期:2005-08-22 00:00:00
abstract::A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000195668.07467.a8
更新日期:2006-02-06 00:00:00
abstract::Methylphenidate (Ritalin) is a psychostimulant drug used to treat children with attention deficit hyperactivity disorder. Despite its widespread and increasing clinical use, little is known about the long-term consequences of drug treatment. We compared the effects of a single injection of methylphenidate with that of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200304150-00022
更新日期:2003-04-15 00:00:00
abstract::Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00012
更新日期:1997-11-10 00:00:00
abstract::One problem in motor control concerns the mechanism whereby the central nervous system translates the motor cortical command encoded in cell activity into a coordinated contraction of limb muscles to generate a desired motor output. This problem is closely related to the design of adaptive systems that transform neuro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199611040-00038
更新日期:1996-11-04 00:00:00
abstract::Spinal cord injury (SCI) causes motor dysfunction and depression, which hinders the recovery of motor function. Body weight-supported treadmill training (BWSTT) should be considered an effective method for functional rehabilitation after SCI, as it is an efficacious intervention in healthcare with no side effects. Bec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001543
更新日期:2020-12-16 00:00:00
abstract::The distribution of PKCepsilon and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCepsilon immunoreactivity were highest in the cingulate cortex and dentate gyrus, moderate in the nucleus accumbens, a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200003200-00006
更新日期:2000-03-20 00:00:00
abstract::The in-vivo extracellular release of acetylcholine (ACh) from the striatum of rats was measured by intracerebral microdialysis. The ACh levels were first estimated under normoxic conditions, after which the rats were exposed to either 10% or 5% oxygen for 1 h. The average ACh content was 2.9 pmol/20 min. During hypoxi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199011000-00005
更新日期:1990-11-01 00:00:00
abstract::Other-race faces are less accurately recognized than same race faces but classified faster by race. Using event-related potentials (ERPs), we captured the brain temporal dynamics of face classification by race processing performed by 12 Caucasian participants. As expected, participants were faster to classify by race ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200404090-00034
更新日期:2004-04-09 00:00:00
abstract::Apolipoprotein E (apoE) and the beta-amyloid peptide are both found in the senile plaques associated with Alzheimer's disease. Several studies have recently determined that apoE can prevent beta-amyloid fibril (Abetaf) formation in vitro. In vivo, apoE is normally associated with a lipid source. We show that both reco...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810050-00031
更新日期:1998-10-05 00:00:00
abstract::The hypothesis that sleep participates in the consolidation of recent memory traces has been investigated using four main paradigms: (1) effects of post-training sleep deprivation on memory consolidation, (2) effects of learning on post-training sleep, (3) effects of within sleep stimulation on the sleep pattern and o...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/00001756-200112210-00001
更新日期:2001-12-21 00:00:00
abstract::Metabolic hypofunction is a common finding in a number of neurodegenerative diseases, including Alzheimer's disease (AD). The strong linkage between the amyloid precursor protein (APP) and AD led us to examine whether over-expression of this protein in CNS-type cells had an effect on mitochondria. We found abnormal mo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199901180-00008
更新日期:1999-01-18 00:00:00
abstract::Previous studies have suggested that the dorsomedial prefrontal cortex (dmPFC) plays a central role in processing first impressions; however, little is known about how dmPFC processes different valences of first impressions. Moreover, it is still unclear as to whether the dmPFC shows lateralization or only induces dif...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000571
更新日期:2016-05-25 00:00:00
abstract::As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse str...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200108080-00015
更新日期:2001-08-08 00:00:00
abstract::Numerous reports have shown that cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, critically contributes to the induction and maintenance of chronic pain induced by peripheral inflammation and nerve injury. Recent evidence has also suggested the critical role of an epigenetic mechanism in ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000237
更新日期:2014-10-01 00:00:00
abstract::Using PET, subtraction and correlation analysis were jointly employed to determine the specific and complementary contributions of frontal and medial temporal regions to verbal episodic encoding and retrieval processes. Subtraction analysis highlighted prefrontal rCBF increases which were predominantly left-sided duri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00044
更新日期:2001-06-13 00:00:00
abstract::Zinc appears to have a role in binding amyloid precursor protein in vitro, but it is not known whether zinc plays a role in senile plaque formation in vivo in humans. Serum zinc concentrations were available from 12 sisters who died in the Nun Study, a longitudinal study of aging and Alzheimer's disease. Fasting serum...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199511000-00002
更新日期:1995-11-13 00:00:00
abstract::Schwann cells at the somatic neuromuscular junction possess adenosine receptors that when activated by the release of endogenous transmitter modulate quantal transmitter release. Recently, purinergic receptors have been shown to exist on Schwann cells of axon varicosities in visceral smooth muscle where they are activ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000209001.09987.77
更新日期:2006-04-03 00:00:00
abstract::The aim of the study was to investigate differences in the distribution of intranasal trigeminal receptors in humans using an electrophysiological measure of trigeminally induced activation, the negative mucosa potential. A total of 29 young, healthy volunteers participated, results were on the basis of data from 18 p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000224764.61959.e8
更新日期:2006-09-18 00:00:00
abstract::The effects of copper on voltage-gated A-type potassium currents were investigated in acutely dissociated rat hippocampal CA1 neurons using the whole-cell patch-clamp technique. Extracellular application of various concentrations of copper (1-1000 microM) reversibly reduced the amplitude of voltage-gated A-type potass...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000181578.72894.b9
更新日期:2005-09-28 00:00:00
abstract::The aim of this study was to evaluate the contribution of ionotropic glutamate receptors to kindled seizure-evoked somatostatin release in the hippocampus, using a microdialysis approach. Basal and amygdala stimulation-evoked somatostatin-like immunoreactivity (-LI) release was significantly greater in kindled compare...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200009280-00032
更新日期:2000-09-28 00:00:00
abstract::The neuropeptide nociceptin/orphanin FQ (N/OFQ) is implicated in many biological functions, including nociception, locomotor activity, stress and anxiety, drinking and food-intake. N/OFQ has also been reported to play a facilitatory role in acute kainate-induced seizures. The aim of the present study was to investigat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200305060-00009
更新日期:2003-05-06 00:00:00