The Xenopus noggin promoter drives roof-plate specific transcription.

Abstract:

:During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this issue, we identified a 2066 bp Xenopus noggin 5' flanking sequence which recapitulates the roof-plate expression of endogenous gene in transgenic frog tadpoles and we further mapped the roof-plate enhancer to a sequence as short as 79 bp. Our results, therefore, not only shed light on but also provide a powerful tool to the study of neural and somite patterning.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Geng X,Xiao L,Tao Q,Hu R,Rupp RA,Ding X

doi

10.1097/00001756-200312020-00006

subject

Has Abstract

pub_date

2003-12-02 00:00:00

pages

2163-6

issue

17

eissn

0959-4965

issn

1473-558X

journal_volume

14

pub_type

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