Abstract:
:During vertebrate neural development, inductive signals derived from the roof plate specify dorsal neural cell types of spinal cord as well as adjacent dermomytotome. Noggin has been demonstrated to play a pivotal role in this signaling network but how its expression is regulated remains unclear. To investigate this issue, we identified a 2066 bp Xenopus noggin 5' flanking sequence which recapitulates the roof-plate expression of endogenous gene in transgenic frog tadpoles and we further mapped the roof-plate enhancer to a sequence as short as 79 bp. Our results, therefore, not only shed light on but also provide a powerful tool to the study of neural and somite patterning.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Geng X,Xiao L,Tao Q,Hu R,Rupp RA,Ding Xdoi
10.1097/00001756-200312020-00006subject
Has Abstractpub_date
2003-12-02 00:00:00pages
2163-6issue
17eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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