Abstract:
:The brain constructs multiple representations of near and far space but it is unclear which spatial mechanism guides reaching across eye movements in near space. Retinocentric reaching representations are known to exist in parietal cortex, but must be updated during eye movements, in order to remain accurate. In contrast, non-retinal (e.g. muscle-centered) reaching plans in motor cortex do not require updating, and so may provide a more stable encoding mechanism. To test between these, we employed a behavioral test. Subjects briefly foveated a target (located at various depths in near and far space) looked peripherally, then reached toward its remembered location. Surprisingly, subjects did not use the stable non-retinal reaching plan (compared to controls without eye movements). Instead, the intervening eye movements induced a systematic pattern of reaching errors for targets at all depths consistent with updating in a retinal frame. We conclude that a common eye-centered updating mechanism prevails in programming arm movements in both near and far space.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Medendorp WP,Crawford JDdoi
10.1097/00001756-200204160-00019subject
Has Abstractpub_date
2002-04-16 00:00:00pages
633-6issue
5eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Alopecia areata (AA) is a dermatosis involving the sudden occurrence of bald patches on the scalp. Although the aetiology is unknown, experimental data indicate that cutaneous microcirculation plays an important role. The skin is richly innervated by neuropeptidergic sensory nerves that help regulate microvascular cir...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00015
更新日期:1997-03-24 00:00:00
abstract::Although beta-amyloid precursor protein (APP) has been suggested to play a role in neuronal survival and plasticity, the mRNA expression of APP has not been studied in terms of neuronal activity. In cultures of mouse cerebellar granule cells, we found that the levels of APP mRNA increased when a high concentration of ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000127140.54853.04
更新日期:2004-06-07 00:00:00
abstract::The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200502080-00020
更新日期:2005-02-08 00:00:00
abstract::Rats with bilateral electrolytic lesions of the perirhinal cortex and sham operated control rats were tested in a spatially guided, delayed non match to sample task. Although perirhinal lesioned animals showed no deficit in acquisition of the task, a performance deficit was observed across longer delay intervals. Thes...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1994-06-27 00:00:00
abstract::Demyelinated CNS axons can be remyelinated by Schwann cells. A recent study concluded that with time Schwann cell remyelination is replaced by oligodendrocyte remyelination [9]. To examine this, the extent of Schwann cell and oligodendrocyte remyelination at 4, 6.5 and 24 weeks was determined for ethidium bromide lesi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207020-00027
更新日期:2002-07-02 00:00:00
abstract::Group III metabotropic glutamate receptors (mGluR4, 6, 7, 8) are negatively coupled to adenylate cyclase and, when activated presynaptically, decrease the release of glutamate and GABA. We have used intracerebroventricular injections of agonists and antagonists believed to act selectively on these receptors to study t...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199606170-00005
更新日期:1996-06-17 00:00:00
abstract::The changes of nitric oxide synthase (NOS) activity and nitrite level in rat brain regions after spatial learning were investigated. NOS activity was assayed by conversion of [3H]L-arginine to [3H]L-citrulline, and a sensitive fluorometric assay for quantification of nitrite was used. Compared with sham-trained rats, ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705060-00040
更新日期:1997-05-06 00:00:00
abstract::The present study explored duration mismatch negativity (MMN) reduction in schizophrenia. Duration MMN studies usually employ tones of very short duration (< 200 ms). For stimuli < 200 ms in duration, an increment in duration is accompanied by an increase in perceived loudness. It was previously proposed that the effe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200112210-00042
更新日期:2001-12-21 00:00:00
abstract::To determine whether EEG synchronization in sleep has a metabolic equivalent, we investigated state-dependent changes in extracellular concentrations of amino acids. In vivo microdialysis studies were performed in the ventroposterolateral (VPL) nuclei of the thalamus of cats during natural slow wave sleep (SWS), wakin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703240-00025
更新日期:1997-03-24 00:00:00
abstract::In the present study, the activity changes of chicken retinal ganglion cells in response to light stimuli with defined contrast were investigated, in the presence of various levels of sustained background illumination. Following a step increase of light illumination, the firing rate of most retinal ganglion cells incr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200503150-00013
更新日期:2005-03-15 00:00:00
abstract::Experimental animals and patients are immobilized to allow continuous monitoring of physiological parameters. Restraint stress affects brain neurotransmitter levels and induces expression of immediate early genes. Whether immobilization stress affects outcomes in newborn animals which have suffered a hypoxic-ischaemic...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199601310-00025
更新日期:1996-01-31 00:00:00
abstract::The protein p42(IP4) (also called centaurin alpha), identified as a brain-specific InsP4/PtdInsP3 (PIP3)-binding protein, has been shown to be localized in human brain, specifically expressed in neurons. Several casein kinases have been found to be involved in Alzheimer's disease (AD) pathology. Since casein kinase I ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200212200-00008
更新日期:2002-12-20 00:00:00
abstract::Piccolo is one of the components of the active zone at chemical synapses and regulates the transport of synaptic vesicles. The piccolo C2A domain is an important calcium sensor and binds with phosphatidylinositol or synaptotagmin-1. Recently, clinical studies suggested that a single nucleotide polymorphism in the picc...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283411685
更新日期:2010-12-29 00:00:00
abstract::Adult rats were studied for serotonin and its metabolite in basal ganglia, nociceptive responses to electric current and tremor induced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) to assess the effects of a single systemic injection of serotonin antiserum given at 1 day old. Antiserum-treated animals showed no over...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Reorganization of motor execution and imagination networks was studied in six patients with unilateral dystonia secondary to a subcortical stroke and compared with seven control subjects using fMRI. Patients performed imagined and real auditory-cued hand movements. Movements of the dystonic hand resulted in overactivi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200408260-00010
更新日期:2004-08-26 00:00:00
abstract:OBJECTIVE:The traditional Chinese medicine, Dendrobium nobile Lindl. polysaccharides (DNLP), reportedly has neuroprotective effects. However, its effects following ischemic stroke remain unclear. This study aimed to explore the role and mechanism of DNLP in experimental models of inflammation and apoptosis. METHODS:In...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001562
更新日期:2020-12-14 00:00:00
abstract::Ts65DN mice were developed as a model of Down syndrome (DS); they are trisomic for the distal segment of chromosome 16 (MMU16), which contains genes syntenic with some of the genes located on the critical region of human chromosome 21 (HSA21). Since behavioral and neurochemical disturbances have been observed in this ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00012
更新日期:1997-11-10 00:00:00
abstract::Hydroxyindole-O-methyltransferase (HIOMT), is the last enzyme of the melatonin biosynthesis pathway. We have applied immunocytochemistry and in situ hybridization to localize HIOMT producing cells, in the chicken epithalamus including the pineal gland. The selectivity of the hybridization signal over melatoninergic ce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199306000-00052
更新日期:1993-06-01 00:00:00
abstract::In this study, an algorithm is introduced for the automatic detection and simultaneous topographic classification of interictal regional spike activity in pediatric surface EEG records. The algorithm is based on the classification of the topographic distribution of instantaneous power by means of a 'group' trained cla...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199707070-00021
更新日期:1997-07-07 00:00:00
abstract::Adeno-associated virus type2 (AAV-2) binds to heparan-sulfate proteoglycans on the cell surface. In vivo, attachment of viral particles to cells adjacent to the injection tract limits the distribution of AAV-2 when infused into the CNS parenchyma and heparin co-infusion might decrease the binding of AAV-2 particles to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107030-00037
更新日期:2001-07-03 00:00:00
abstract::Motor fluctuations that ultimately complicate the response of most parkinsonian patients to levodopa therapy might represent a form of behavioral or neuronal plasticity. Since various forms of neuronal plasticity appear to be mediated by glutamate transmission through the N-methyl-D-aspartate (NMDA) receptor, the effe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00045
更新日期:1994-12-20 00:00:00
abstract::The function of the lateral part of the human cerebellum was investigated through cerebro-cerebellar functional connectivity. We propose a laterality index method to reveal a functional and possibly anatomical pathway between the cerebral cortex and the cerebellum. The brain activity involved in learning a visually-gu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902050-00022
更新日期:1999-02-05 00:00:00
abstract::We injected neural tracers into the lateral funiculus of the spinal cord in order to relate the sites of origin of the spinal projections from the mesial cortical surface with the cytoarchitectonic organization of this region. We found a close correlation between the origin sites and density of corticospinal projectio...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199412000-00035
更新日期:1994-12-20 00:00:00
abstract::Ischemic stroke is the most frequent cause of long-term morbidity and mortality in the elderly worldwide. Mild hypothermia (32-35°C) has been found to have a neuroprotective effect against ischemic stroke. However, the protective mechanisms remain unclear. In the present study, we explore the neuroprotective effect of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001593
更新日期:2021-01-18 00:00:00
abstract::Mammalian TIMELESS (TIM) was identified due to its sequence similarity to Drosophila TIM, an essential circadian clock protein in flies. Published literature is inconsistent regarding the rhythmic expression of mammalian Tim, the interaction of the TIM protein with other clock proteins and its role in regulating clock...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/01.wnr.0000233092.90160.92
更新日期:2006-08-21 00:00:00
abstract::Diabetes is often associated with impairments in brain functioning. However, the injury of specific functioning areas of the brain is not clear. To address this problem, the present study was designed to investigate possible brain functioning change in specific brain areas, particularly in areas associated with vision...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000703
更新日期:2017-01-18 00:00:00
abstract::This study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye move...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507310-00015
更新日期:1995-07-31 00:00:00
abstract::In this study, we examined the expression of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in dorsal root ganglia (DRG) neurons in two rodent models of nerve injury: sciatic nerve axotomy and streptozotocin-induced (STZ) painful diabetic neuropathy. We demonstrate that IGF-I and its receptor are prefe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200209160-00016
更新日期:2002-09-16 00:00:00
abstract::Consumers often rely on observable cues that hint at the hidden quality of a product. The aim of this study was to investigate brain activities associated with the country-of-origin (COO) effect and consumer evaluation of a product design. Electroencephalogram recordings were used to observe event-related brain potent...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000102
更新日期:2014-03-05 00:00:00
abstract::To clarify the time course of neural responses to faces with different emotional expressions, we used event-related potential (ERP) and reaction time measures. Faces expressing four different emotions (happy, neutral, fearful, disgusted) and houses were shown in both upright and inverted orientations while subjects pe...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200401190-00041
更新日期:2004-01-19 00:00:00