Regional distribution of tau, beta-amyloid and beta-amyloid precursor protein in the Alzheimer's brain: a quantitative immunolabelling study.

abstract：:The pathogenesis of amyotrophic lateral sclerosis remains poorly understood, but microglial and astroglial activation are thought to contribute to motor neuron death. Evidence suggests that matrix metalloproteinase-9 (MMP-9) is a mediator of this deleterious effect. In this study, we evaluated the effect of MMP-9 on t...

journal_title：Neuroreport

authors： Dewil M,Schurmans C,Starckx S,Opdenakker G,Van Den Bosch L,Robberecht W

更新日期：2005-03-15 00:00:00

abstract：:MicroRNAs (miRNAs) have been documented as critical regulators in ischemia/reperfusion-induced neuronal death. A better understanding of miRNA-mediated molecular mechanisms in ischemia/reperfusion-induced neuronal death may provide therapeutic targets for cerebral ischemia/reperfusion injury. A growing body of evidenc...

journal_title：Neuroreport

authors： Xiao J,Kong R,Hu J

更新日期：2018-06-13 00:00:00

abstract：:The present study examined potential neuroprotective effects of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive NMDA antagonist properties on neurones exposed to various excitotoxins in culture. HU-211 was found to protect neurones from NMDA and quisqualate-induced toxicity but not that produced ...

journal_title：Neuroreport

authors： Eshhar N,Striem S,Biegon A

更新日期：1993-12-13 00:00:00

abstract：:We have previously suggested that progranulin mediates the stimulatory effects of estrogen on adult neurogenesis in the hippocampus. Neurogenesis in mature animals is enhanced by growth factors, environmental enrichment, and voluntary exercise. In this study, we investigated the role of progranulin in voluntary runnin...

journal_title：Neuroreport

authors： Asakura R,Matsuwaki T,Shim JH,Yamanouchi K,Nishihara M

更新日期：2011-12-07 00:00:00

abstract：:THE highly selective adenosine A1 receptor agonist N6-cyclohexyladenosine (CHA) significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in the working memory task with a three-panel runway setup, when injected bilaterally at 0.3 and 1....

journal_title：Neuroreport

authors： Ohno M,Watanabe S

更新日期：1996-11-25 00:00:00

abstract：:In previous studies, we demonstrated functional neuronal and dopaminergic differentiation of fetal mesencephalic neural precursor cells. The major factors for orienting their progeny towards a dopaminergic phenotype are forskolin and interleukin-1beta. Here, we investigated the effects of dexamethasone (10 microM) on ...

journal_title：Neuroreport

authors： Sabolek M,Herborg A,Schwarz J,Storch A

更新日期：2006-11-06 00:00:00

abstract：:Decisions made on the basis of risk often require rapid evaluation of feedback before follow-up actions and feedback-related negativity in brain potential is sensitive to the poor outcome. The current study investigated the effects of feedback from one's own decision (Experiment 1) and feedback from observing others' ...

journal_title：Neuroreport

authors： Liu Y,Dou K,Wang Y,Li J

更新日期：2015-11-11 00:00:00

abstract：:The distribution of histamine H1, H3, dopamine D1 and D2 receptors in the brain was studied by receptor autoradiography using a high-sensitivity and high-resolution imaging plate system. [3H]Pyrilamine, [3H](R)alpha-methyl-histamine, [11C]SCH23390, and [11C]N-methylspiperone (or [11C]YM-09151-2) were used as ligands t...

journal_title：Neuroreport

authors： Yanai K,Ryu JH,Watanabe T,Iwata R,Ido T

更新日期：1992-11-01 00:00:00

abstract：:Low doses of estrogen (E) were given to ovariectomized (OVX) rats and the ventromedial hypothalamic nucleus (VMN) was examined at the ultrastructural level. Administration of 10 micrograms of E for two consecutive days resulted in an increase in the number of axodendritic synapses in the VMN in comparison to OVX rats ...

journal_title：Neuroreport

authors： Frankfurt M,McEwen BS

更新日期：1991-07-01 00:00:00

abstract：:To test the possible role of ATP in transducing or modulating touch sensation, an isolated skin-nerve preparation from the toad, Bufo marinus, perfused on the inner side, was used to examine the effects of ATP on slowly adapting (SA) and rapidly adapting (RA) mechanoreceptors, identified by ramp and hold indentation o...

journal_title：Neuroreport

authors： Fallon JB,Maroto R,Hamill OP,Proske U

更新日期：2002-08-07 00:00:00

abstract：:Selective degeneration of hypothalamic orexin neurons, a hallmark of pathology in narcolepsy patients, is in part reproduced in hypothalamic slice cultures by application of an endogenous excitotoxin quinolinic acid. Depolarized membrane potential may be responsible for the vulnerability of orexin neurons to excitotox...

journal_title：Neuroreport

authors： Katsuki H,Akaike A

更新日期：2005-08-01 00:00:00

abstract：:In addition to the study of pathological conditions, magnetic resonance spectroscopy can provide useful information about brain-behavior relationships in normal subjects. Recently, there have been reports of correlations between N-acetylaspartate (NAA) values and cognitive functions in normal adults. We tested the pos...

journal_title：Neuroreport

authors： Giménez M,Junqué C,Narberhaus A,Caldú X,Segarra D,Vendrell P,Bargalló N,Mercader JM

更新日期：2004-03-22 00:00:00

abstract：:Event-related potentials(ERPs) were measured while subjects were constructing mental images of a letter of the alphabet. Following presentation of an uppercase letter, subjects were asked to form a mental image of the same letter in lower case, and determine whether or not it had an ascending or descending stroke (asc...

journal_title：Neuroreport

authors： Yamamoto S,Mukai H

更新日期：1998-10-26 00:00:00

abstract：:A number of epidemiological studies suggest that estrogen therapy is linked to a reduced risk of developing Alzheimer's disease (AD). The present study was conducted to evaluate the effect of 17beta-estradiol on beta-amyloid (Abeta)-induced toxicity and was performed in rat pheochromocytoma PC 12 cells by measuring th...

journal_title：Neuroreport

authors： Svensson AL,Nordberg A

更新日期：1999-11-26 00:00:00

abstract：:Blockade of L-type Ca2+ channels results in a decrease in firing frequency of neostriatal neurons. In contrast, N- and P/Q-types of Ca2+ channel cooperate to tune firing pattern, since both of these channel types have to be blocked to enhance firing frequency. Parameters of the intensity-frequency plot were differenti...

journal_title：Neuroreport

authors： Pérez-Garci E,Bargas J,Galarraga E

更新日期：2003-07-01 00:00:00

abstract：:Chronic nicotine exposure enhances axon reflexes in adult rats. Since smoking mothers expose their infants to nicotine, this study investigated whether late gestational and or lactational maternal nicotine exposure affects neonatal axon reflexes. Osmotic pumps, implanted subcutaneously in adult female rats, delivered ...

journal_title：Neuroreport

authors： Grunfeld JA,Tiedemann GJ,Westerman RA

更新日期：1993-06-01 00:00:00

abstract：:Recently, there has been growing interest in the neurobiological role of some amygdalar neuromediators, such as GABA and orexins (ORX), that are responsible for stressful behaviors. Infusion of the major fear-related and panic-related basolateral amygdalar station, the lateral nucleus, with ORX-A and ORX-B, alone or i...

journal_title：Neuroreport

authors： Avolio E,Biasone A,Mele M,Alò R

更新日期：2014-08-20 00:00:00

abstract：:Prolonged activation of brain N-methyl-D-aspartic acid (NMDA) receptors increases intraneuronal (Ca2+) and nitric oxide (NO) synthesis, and may be responsible for neuronal death in acute brain insults and chronic neurodegenerative diseases. NO can be converted in vitro to toxic hydroxyl (OH) radical. Using microdialys...

journal_title：Neuroreport

authors： Hammer B,Parker WD Jr,Bennett JP Jr

更新日期：1993-10-25 00:00:00

abstract：:Positron emission tomography (PET) was used to investigate cerebral organization in seven subjects who had Mandarin Chinese as their native language (L1), and learned English (L2) later in life. When activation from word repetition was subtracted from verb generation in L1 and L2, CBF increases were observed for both ...

journal_title：Neuroreport

authors： Klein D,Milner B,Zatorre RJ,Zhao V,Nikelski J

更新日期：1999-09-09 00:00:00

abstract：:This study was designed to clarify the neuroprotective effects of tanshinone IIA (TSA) following cerebral ischemic insult. Adult Sprague-Dawley rats were operated upon to achieve a middle cerebral artery occlusion to cause transient focal cerebral ischemia, which were then randomly divided into the sham-operated contr...

journal_title：Neuroreport

authors： Wen PY,Li J,Lu BL,Liu J,Yang FZ,Zhou L,Luo H,Li WW,Zhou J

更新日期：2016-04-13 00:00:00

abstract：:This study investigated whether neural mechanisms of self-face recognition are modulated by attention by recording event-related brain potentials associated with self-face recognition. Participants identified head orientations of self-faces and familiar or unfamiliar other faces presented briefly at the center of the ...

journal_title：Neuroreport

authors： Sui J,Zhu Y,Han S

更新日期：2006-03-20 00:00:00

abstract：:This study was carried out based on the assumption that brain-derived neurotrophic factor (BDNF) may counterbalance the action of morphine in the brain. Morphine analgesic tolerance after daily administrations for six days was blocked by intracerebroventricular injection of anti-BDNF IgG on day 5, but not by administr...

journal_title：Neuroreport

authors： Matsushita Y,Ueda H

更新日期：2009-01-07 00:00:00

abstract：:Hemispheric (re-)organization of episodic memory functions after temporal lobe damage (TLD) was investigated by the intracarotid amobarbital procedure in patients suffering temporal lobe epilepsy. Memory of the speech-dominant left hemisphere was intact after right-sided TLD independent of the age at manifestation. In...

journal_title：Neuroreport

authors： Jokeit H,Ebner A,Holthausen H,Markowitsch HJ,Tuxhorn I

更新日期：1996-07-08 00:00:00

abstract：:Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. Their site and mechanism of action, however, are still poorly understood. To increase our knowledge of the histaminergic system in the vestibular organs, we have investigated the expression of H1 and H3 histamine re...

journal_title：Neuroreport

authors： Botta L,Tritto S,Perin P,Laforenza U,Gastaldi G,Zampini V,Zucca G,Valli S,Masetto S,Valli P

更新日期：2008-03-05 00:00:00

abstract：:Unilateral neglect has been recently shown to be improved following a short period of adaptation to wedge prisms. The present study investigates whether visuo-motor adaptation can generate a bias in normals on line bisection tasks classically used to assess unilateral neglect. Our results show that adaptation to left-...

journal_title：Neuroreport

authors： Colent C,Pisella L,Bernieri C,Rode G,Rossetti Y

更新日期：2000-06-26 00:00:00

abstract：:It is difficult to induce long-term potentiation (LTP) in CA1 of hippocampal slices from 120-day-old rats when a single 100 Hz, 1 s tetanus is administered in extracellular solution containing 2.0 mM calcium and 2.0 mM magnesium. However, in the presence of 2.5 mM calcium and 1.3 mM magnesium LTP is reliably induced b...

journal_title：Neuroreport

authors： Izumi Y,Zorumski CF

更新日期：1998-11-16 00:00:00

abstract：:Using in situ hybridization histochemistry and immunocytochemistry the induction of immediate early genes (IEGs) was studied in the rat superior cervical ganglion (SCG) after deafferentation, axotomy and sialectomy (removal of the submandibular gland). Control SCGs showed very low levels of IEGs, whereby Fos proteins ...

journal_title：Neuroreport

authors： Koistinaho J,Pelto-Huikko M,Sagar SM,Dagerlind A,Roivainen R,Hökfelt T

更新日期：1993-01-01 00:00:00

abstract：:Where and how the cortical areas are activated when a person receives the result of hypothesis testing is still unclear. By using a category induction task, this study provided participants with various batteries and asked them to learn which kind of batteries were charged. After learning, they were required to give a...

journal_title：Neuroreport

authors： Li F,Cao B,Lei Y,Li H

更新日期：2009-01-28 00:00:00

abstract：:The mechanism by which IL-1 beta exerts its actions in the brain during systemic inflammation is not fully understood, as neither IL-1 receptor gene expression nor IL-1 binding have been identified in significant levels in key areas that respond to IL-1 beta. Having hypothesized that perivascular nitric oxide (NO) mig...

journal_title：Neuroreport

authors： Wong ML,Bongiorno PB,al-Shekhlee A,Esposito A,Khatri P,Licinio J

更新日期：1996-11-04 00:00:00

abstract：:Magnetoencephalography (MEG) was used to compare mismatch responses between hemispheres to changes in sound-source direction. Sixteen adults listened passively to two types of complex non-language sounds presented in separate blocks with midline standards and right- and left-lateralized deviants. Mismatch dipole ampli...

journal_title：Neuroreport

authors： Kaiser J,Lutzenberger W,Birbaumer N

更新日期：2000-09-11 00:00:00