Abstract:
:The mechanism by which IL-1 beta exerts its actions in the brain during systemic inflammation is not fully understood, as neither IL-1 receptor gene expression nor IL-1 binding have been identified in significant levels in key areas that respond to IL-1 beta. Having hypothesized that perivascular nitric oxide (NO) might modulate the effects of systemic IL-1 beta in the brain, we studied the expression of the genes encoding for IL-1 beta, the signal-transducing IL-1 receptor type I (IL-1RI) and inducible NO synthase (iNOS) constitutively and during systemic inflammation in vascular and perivascular regions of the rat brain. Our results show that IL-1RI is constitutively expressed at the interface of the vascular wall and perivascular glia. During systemic inflammation there is induction of IL-1 beta gene expression in the vascular wall, accompanied by perivascular induction of iNOS mRNA. We conclude that during systemic inflammation vascular IL-1 beta, binding to vascular and perivascular IL-1RI receptors, may induce perivascular iNOS gene expression, leading to the production of NO and modulation of the effects of IL-1 beta in the brain. We propose that the vascular and peri-vascular induction of iNOS mRNA by IL-1 beta might represent a mechanism for the modulation of the central nervous system effects of peripheral inflammatory mediators.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Wong ML,Bongiorno PB,al-Shekhlee A,Esposito A,Khatri P,Licinio Jdoi
10.1097/00001756-199611040-00008subject
Has Abstractpub_date
1996-11-04 00:00:00pages
2445-8issue
15-17eissn
0959-4965issn
1473-558Xjournal_volume
7pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Models of corticostriatal motor circuitry have focused on the role of the circuit in the hemisphere of the motor cortex providing primary control (contralateral to the movement). We used functional magnetic resonance imaging and functional connectivity analyses to study circuit function in both the controlling and non...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328302c873
更新日期:2008-06-11 00:00:00
abstract::Areas of the brain's left hemisphere involved in retrieving words with emotional connotations were studied with fMRI. Participants silently generated words from different semantic categories which evoked either words with emotional connotations or emotionally neutral words. Participants repeated emotionally neutral wo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199908200-00003
更新日期:1999-08-20 00:00:00
abstract::DCC is a member of the immunoglobulin superfamily of cell adhesion molecules, whose role in the function of the adult nervous system is unknown. DCC mRNA expression was studied in adult rat dorsal hippocampal sections using in situ hybridization histochemistry. High levels of DCC transcript were detected in hippocampu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199709080-00022
更新日期:1997-09-08 00:00:00
abstract::Two well-known appetite-regulatory peptides, leptin and cocaine- and amphetamine-regulated transcript (CART), are known to be involved in the brain rewarding pathway. However, it is not yet known how they interact in the nucleus accumbens, an important region mediating the rewarding effects of drugs of abuse. Using th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000822
更新日期:2017-08-02 00:00:00
abstract::We investigated the effects of 2,2,2-trichloroethanol (TCE), the active metabolite of chloral hydrate, on large-conductance calcium-activated K+ channels (BKCa channels) of dorsal root ganglion (DRG) neurones. In outside-out patches, 2 and 5 mM TCE increased the open probability of BKCa channels to 1.7-fold and 2.8-fo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200205070-00023
更新日期:2002-05-07 00:00:00
abstract::We determined whether acute compensatory feeding pattern changes after bulbectomy persist on a chronic basis, or whether physiological adaptation occurs to normalize acute changes. Rats were randomized to olfactory bulbectomy or sham operation; all had jugular vein catheterization. Food intake, meal number and size we...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199704140-00023
更新日期:1997-04-14 00:00:00
abstract::The present study aimed to confirm and extend the finding, suggested by the results of a previous study, of different auditory neural efferent functioning in musicians compared with non-musicians. The activity of the medial olivocochlear bundle (MOCB), an auditory efferent subsystem, was measured through the contralat...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199703030-00046
更新日期:1997-03-03 00:00:00
abstract::In this study, we ask whether or not the involuntary capture of attention by a specific information type can produce domain-specific activation. Participants indicated the presence of a flicker in rapidly alternating letter-string masks presented in the periphery. Despite letters not being relevant to the task, we fou...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3281668bcc
更新日期:2007-07-02 00:00:00
abstract::Neuroimaging techniques, such as fMRI, PET and near-infrared spectroscopy, monitor task-related neuronal activations in the brain indirectly through the associated neurovascular/metabolic responses. To assess the primary neuronal activations directly, magnetoencephalography was combined here with a mechanical modulati...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200106130-00034
更新日期:2001-06-13 00:00:00
abstract::Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834558df
更新日期:2011-03-30 00:00:00
abstract::The present study examined the distribution in the human spinal cord of a unique carboxy terminus sequence contained within MOR-1C, one of the recently described splice variants of the cloned mu opioid receptor gene MOR-1. Although MOR-1-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200006260-00029
更新日期:2000-06-26 00:00:00
abstract::The auditory-evoked potential's N1 component of the scalp electroencephalogram is a well-established measure of electrical brain activity. The N1 reflects basic auditory processing and is modulated by auditory experience, for instance, by musical training. Here, we explore a possible correlation between the auditory N...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32835abc5c
更新日期:2012-12-05 00:00:00
abstract::Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The present study tests the hypothesis that hypoxia results in increased expression of caspas...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000835
更新日期:2017-08-16 00:00:00
abstract::High concentrations of local anesthetics are neurotoxic, but the mechanism for this neurotoxicity is obscure. Here, we report increased concentrations of glutamate in the cerebrospinal fluid after intrathecal injections of high concentrations of tetracaine (a local anesthetic). The peak concentrations of glutamate aft...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200004070-00039
更新日期:2000-04-07 00:00:00
abstract::Direct currents (DC) applied directly to central nervous system structures produce substantial and long-lasting effects in animal experiments. We tested the functional effects of very weak scalp DC (< 0.5 mA, 7 s) on the human motor cortex by assessing the changes in motor potentials evoked by transcranial magnetic br...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-199807130-00020
更新日期:1998-07-13 00:00:00
abstract::Endothelin-1 (ET-1) is recognized as being involved in the pathophysiology of cerebrovascular diseases. Using organ culture as a model for possible pathological changes we studied changes in ET(A) and ETB receptor function using a sensitive in vitro method. We observed an up-regulation of the ET(B) receptor and an ama...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200002280-00042
更新日期:2000-02-28 00:00:00
abstract::Pharmacological manipulation of brain dopamine concentration affects visuospatial working memory in humans and in animals, the latter effects localized to the prefrontal cortex. However, the effects of dopamine agonists on humans are poorly understood. We hypothesized that bromocriptine would have an effect on cogniti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199711100-00032
更新日期:1997-11-10 00:00:00
abstract::Although valproate (VPA) is used widely in the treatment of bipolar mood disorder and epilepsy, the precise mechanism of action in the brain remains elusive. In this study, we investigated the effects of subchronic VPA administrations on the expression of the cyclin-dependent kinase inhibitor (Cdkn) family in the hipp...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000448
更新日期:2015-10-21 00:00:00
abstract::This study is to explore the involvement of muscarinic acetylcholine receptors/protein kinase C cascade and the mitogen-activated protein kinase pathway in the effect of huperzine A on the secretory amyloid precursor protein-alpha. Upregulation of secretory amyloid precursor protein-alpha by huperzine A was attenuated...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280c1e28c
更新日期:2007-05-07 00:00:00
abstract::Increased expression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are early, critical events in several forms of apoptosis. In order to investigate the subcellular trafficking of GAPDH in vivo, the localization of a GAPDH-green fluorescent protein (GFP) fusion was studied in PC12, HEK 2...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199904060-00045
更新日期:1999-04-06 00:00:00
abstract::While dopamine mechanisms play a crucial role in cocaine-taking behavior, the contribution of endogenous opioid systems is less clear. We assessed the effects of opioid receptor blockade by naloxone (1 mg/kg, s.c.) on the daily performance and subsequent initiation of cocaine self-administration in trained rats. Nalox...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200302100-00019
更新日期:2003-02-10 00:00:00
abstract::Dopamine plays important functional roles in the vertebrate retina. Here we show that functional D2 dopamine receptors are present on mammalian retinal Müller (glial) cells. Using an antiserum directed to two oligopeptides predicted from rat D2 receptor DNA, patchy label was demonstrated immunocytochemically on virtua...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199503000-00006
更新日期:1995-03-07 00:00:00
abstract::Diffusion tensor imaging is a new in vivo tool not only for the assessment of white matter structural integrity but also for diagnosis and assessment of disease conditions which disturb tissue structural coherence. In this study, we investigated the integrity of auditory pathway in patients of sensorineural hearing lo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000134584.10207.1a
更新日期:2004-08-06 00:00:00
abstract::This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328301a629
更新日期:2008-06-11 00:00:00
abstract::The brain-derived neurotrophic factor (BDNF) affects the developing cerebellar granule cells. Exposure of 9-11-day-old primary cultures of rat cerebellar granule neurones for 3 h to a more depolarizing medium (additional 15-30 mM KCl) stimulated the release of glutamate and increased the BDNF mRNAs levels. This BDNF a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1993-09-03 00:00:00
abstract::Formalin fixation reduces beta-amyloid precursor protein (beta APP) immunoreactivity which restricts its study in archival tissue. Formic acid pretreatment has previously been used in an attempt to overcome this problem, but makes the sections very friable. In the present study, a microwave antigen retrieval method ha...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199405000-00016
更新日期:1994-05-09 00:00:00
abstract::Myelinated nerve fibers exhibit a complex anatomy in the nodal region which includes a marked nodal-paranodal constriction and an intricate paranodal structure where the myelin sheath is separated from the axon by a narrow periaxonal space. In this study, a recently developed computational model of the mammalian myeli...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199301000-00023
更新日期:1993-01-01 00:00:00
abstract::We studied the distribution of phosphorylated tau (p-tau) in neonatal and adult rat cerebrum using monoclonal antibodies that recognize distinct tau epitopes in a phosphorylation-dependent manner. In neonatal cortex, p-tau was detected in the apical dendrites and somata of pyramidal neurons as well as in axons. In adu...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199708180-00029
更新日期:1997-08-18 00:00:00
abstract::This study examined the hypothesis that cholinergic receptor mechanisms within the gigantocellular tegmental field (FTG) of the medial pontine reticular formation can cause state-dependent changes in the firing rates of parabrachial nuclear complex (PBNC) neurons. Using intact, unanesthetized cats, long-term recording...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199303000-00011
更新日期:1993-03-01 00:00:00
abstract::We previously reported that withdrawal from chronic cocaine produces supersensitivity of serotonin 2A receptors. We report here the minimum cocaine exposure necessary to produce withdrawal-associated increases in serotonin 2A receptor signaling in the frontal cortex. Rats withdrawn from cocaine treatments of 1, 3 or 7...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000246324.43567.55
更新日期:2007-01-08 00:00:00