Abstract:
:This study examined the hypothesis that cholinergic receptor mechanisms within the gigantocellular tegmental field (FTG) of the medial pontine reticular formation can cause state-dependent changes in the firing rates of parabrachial nuclear complex (PBNC) neurons. Using intact, unanesthetized cats, long-term recordings were obtained from single PBNC neurons following FTG administration of cholinergic agonists and antagonists. We show that the state-dependent decrease in PBNC cell discharge reported in this study can be attributed to muscarinic mechanisms within the FTG. Our pharmacological blocking results further suggest that diminished PBNC discharge was mediated by non-M1 muscarinic receptors in the FTG. This study demonstrates the usefulness of combining long-term neuronal recordings in the PBNC with multiple pharmacological manipulations within the FTG.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Gilbert KA,Lydic Rdoi
10.1097/00001756-199303000-00011subject
Has Abstractpub_date
1993-03-01 00:00:00pages
271-4issue
3eissn
0959-4965issn
1473-558Xjournal_volume
4pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Alzheimer disease (AD) patients show increased plasma levels of homocysteine, whose conversion to methionine is catalyzed by methionine synthase (MS). Although altered MS activity may result from the MS A2756G polymorphism, the latter's possible associ-ation with AD remains unexplored. To assess whether the MS A2756G ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000073683.00308.0e
更新日期:2003-07-18 00:00:00
abstract::Hypoxia or global ischemia causes rapid loss of consciousness and a sudden increase in spontaneous transmitter release suggesting that coordinated synaptic activity is impaired. Gamma oscillations (30-100 Hz) are thought to provide for binding of parallel processed information in the brain, contributing to cognition a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282f13e4f
更新日期:2007-11-19 00:00:00
abstract::The majority of retinal ganglion cells innervating the suprachiasmatic nucleus are intrinsically light sensitive, while the rest are conventional ganglion cells that collect inputs through conventional photoreceptors. Here we report a rarely encountered ganglion cell that had a dendritic field covering approximately 1...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000234757.26610.e8
更新日期:2006-10-02 00:00:00
abstract::Primate vision consists mostly of periods of stable fixation separated by rapid saccadic eye movements. Each saccade brings a new scene onto the retina, and each new scene results in a burst of activity in the neurons of visual cortex. It might be expected that the activity of these neurons should only represent what ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200301200-00020
更新日期:2003-01-20 00:00:00
abstract::Participation of the neuronal nicotinic receptor subunit alpha6 in a physiologically relevant receptor has yet to be demonstrated, but its high degree of expression in catecholaminergic nuclei has attracted considerable interest. To investigate the pattern of expression of the alpha6 protein, a subunit specific antibo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199708180-00019
更新日期:1997-08-18 00:00:00
abstract::This study used functional magnetic resonance imaging to characterize hemodynamic activation patterns recruited when the participants viewed mixed social communicative messages during a common interpersonal exchange. Mixed messages were defined as conflicting sequences of biological motion and facial affect signals th...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283455c23
更新日期:2011-06-22 00:00:00
abstract::To investigate the implications of duration of deafness in the rehabilitation of unilateral deafness utilizing cochlear implantation. From the ongoing prospective cochlear implantation in unilateral deafness study, we looked at five adults who received a cochlear implant for long-term unilateral deafness. Speech perce...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283642a93
更新日期:2013-09-11 00:00:00
abstract::The aim of this study was to show that Cl(-)-dependent excitotoxicity, with its characteristic cell swelling, involves actual water influx into the intracellular compartment. Taking advantage of the Ca2+ omission paradigm of Cl(-)-dependent excitotoxicity, in the chick embryonic neural retina ex vivo, which is associa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011270-00037
更新日期:2000-11-27 00:00:00
abstract::We investigated the age-related change in the distribution of a molecular marker for neural stem and precursor cells, Musashi-1, in the olfactory epithelium of mice from 1 day up to 16 months of age using immunohistochemistry. We also compared the distribution pattern of Musashi-1 with that of growth-associated protei...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3280bef7e2
更新日期:2007-05-07 00:00:00
abstract::Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830867c4
更新日期:2008-07-16 00:00:00
abstract::Amyotrophic lateral sclerosis is an incurable disease in which cerebral and spinal motoneurons degenerate, causing paralysis and death within 2-5 years. One of the pathogenic factors of motoneuron death is a chronic excess of glutamate, which exceeds its removal by astrocytes, i.e. excitotoxicity. Extra glutamate upta...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200310270-00017
更新日期:2003-10-27 00:00:00
abstract::ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200409150-00021
更新日期:2004-09-15 00:00:00
abstract::Two voltage-activated Na+ channel blockers, lamotrigine and flunarizine were applied ionophoretically to extracellularly recorded dorsal horn neurones to assess effects on activation by noxious (mustard oil) and innocuous (brush) stimuli. Lamotrigine and flunarizine caused significantly greater reductions in mustard o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199705060-00001
更新日期:1997-05-06 00:00:00
abstract::Oleic acid, a cis-unsaturated free fatty acid, is proposed to be involved in the protein kinase C (PKC) activation pathway. Its biological actions, however, have not been well-characterized. We examined the effects of oleic acid on acetylcholine (ACh)-gated channel currents using Torpedo nicotinic ACh receptors expres...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199702100-00004
更新日期:1997-02-10 00:00:00
abstract::In acute experiments, the effects of i.p. 17beta-estradiol on the activity of arcuate neurons were studied in ovariectomized rats. 17Beta-estradiol (100 microg/100g, i.p.) increased the spontaneous activity of the observed arcuate neurons with a latency of 20-25 min. In some neurons spontaneous activity could be influ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199911260-00034
更新日期:1999-11-26 00:00:00
abstract::We recorded event-related potentials (ERPs) in 2-month-old infants in two different states of alertness: awake and asleep. Syllables varying in vowel duration (long vs short) were presented in an oddball paradigm, known to elicit a mismatch brain response. ERPs of both groups showed a mismatch response reflected in a ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200207190-00006
更新日期:2002-07-19 00:00:00
abstract::This study examined the basis for introducing an ignoring task during cortical evoked response audiometry (CERA) using the N1-P2 response. Healthy hearing participants were assigned to two groups with and without an ignoring task (ignoring and listening groups) during CERA whose outcomes were compared with the pure-to...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833b502a
更新日期:2010-07-14 00:00:00
abstract::Methylphenidate (Ritalin) is a psychostimulant drug used to treat children with attention deficit hyperactivity disorder. Despite its widespread and increasing clinical use, little is known about the long-term consequences of drug treatment. We compared the effects of a single injection of methylphenidate with that of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200304150-00022
更新日期:2003-04-15 00:00:00
abstract::The serum-free mouse embryo (SFME) cell line, derived from 16-day-old mouse embryos in medium in which serum was replaced by growth factors and other supplements, has been cultured for more than 200 generations. SFME cells are nontumorigenic, lack gross chromosomal abnormalities, and display characteristics of CNS pro...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199408150-00011
更新日期:1994-08-15 00:00:00
abstract::The aim of this study is to investigate the neural mechanism of extending a brand in a specific product category to other product categories. Facing two sequential stimuli in pairs consisting of beverage brand names (stimulus 1) and product names (stimulus 2) in other categories, 16 participants were asked to indicate...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3281667d59
更新日期:2007-07-02 00:00:00
abstract::Olfactory cues can elicit intense emotional responses. This study used fMRI in male common marmoset monkeys to identify brain areas associated with sexual arousal in response to odors of ovulating female monkeys. Under light anesthesia, monkeys were secured in a specially designed restrainer and positioned in a 9.4 T ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200107200-00037
更新日期:2001-07-20 00:00:00
abstract::Ascorbate and glutathione (GSH) are the primary water-soluble antioxidants in the CNS. Oxidative stress, sometimes indicated by loss of these antioxidants, has been linked to several clinical and experimental conditions, including cerebral ischemia. These conditions are also gender-linked, with greater incidence or se...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199507310-00005
更新日期:1995-07-31 00:00:00
abstract::Microglia are the only immunocompetent cells resident in the central nervous system which are capable of protecting the brain from infection and tumors. These resident macrophages possess a vast array of mechanisms for the destruction of bacteria and tumor cells. One of these mechanisms involves the generation of nitr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199404000-00031
更新日期:1994-04-14 00:00:00
abstract::Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328326a031
更新日期:2009-03-04 00:00:00
abstract::We obtained visual response latencies and response durations following visual stimulation of neurones recorded in the lateral geniculate nucleus (LGN), areas 17, 18, 19, the posteromedial lateral suprasylvian sulcus (PMLS), and area 7 of the cat. We found an increasing lengthening of the mean response latencies, consi...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199404000-00010
更新日期:1994-04-14 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in drug tolerance and regulating pain. The purpose of the present study is to explore the regulatory mechanism of miR-124-3p on dezocine tolerance against pain in a rat model. The expression of miR-124-3p and TRAF6 in spinal cord of rats was detected by quantitative reverse-tran...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001559
更新日期:2021-01-06 00:00:00
abstract::Insulin-like growth factor (IGF)-I is essential for cerebellar granule neuron survival and a decline in IGF-I is implicated in various age-dependent processes. Here we show that IGF-I mRNA levels are decreased in the cerebellum of old rats compared with young rats and this was associated with increased cell death and ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200308260-00018
更新日期:2003-08-26 00:00:00
abstract::We investigated the influence of noise on brain responses to spoken sentences in MEG. Sixteen subjects had to listen to acoustically presented sentences and judge their syntactic correctness. Sentences were either presented on a silent background or with noise. Noise had differential effects on early auditory and synt...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/00001756-200002070-00001
更新日期:2000-02-07 00:00:00
abstract::Mitochondrial dysfunction and oxidative stress are implicated in the pathological changes observed in the diabetic central nervous system. In this study, using the streptozotocin-induced diabetic rat model we document for the first time the over-expression of a mitochondrial specific stress protein (chaperonin 60) in ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000201503.15632.06
更新日期:2006-02-27 00:00:00
abstract::Event-related potentials (ERPs) were measured from 24 chronic closed head injury (CHI) patients and 18 age- and education-matched controls. The oddball paradigm was applied while subjects were watching a silent movie. The standard (p=0.8) sound of 75 ms duration had a basic frequency of 500 Hz with harmonic partials o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200105250-00043
更新日期:2001-05-25 00:00:00