Abstract:
:Models of corticostriatal motor circuitry have focused on the role of the circuit in the hemisphere of the motor cortex providing primary control (contralateral to the movement). We used functional magnetic resonance imaging and functional connectivity analyses to study circuit function in both the controlling and noncontrolling hemispheres. During the completion of a unilateral motor task with either hand, each putamen nucleus demonstrated strong coactivation with structures in both hemispheres. The putamen in the noncontrolling hemisphere (ipsilateral to the movement) coactivated more strongly with the controlling motor cortex than with the noncontrolling cortex. These findings suggest that the two corticostriatal circuits are functionally integrated. New circuit models based on functional connectivity may need to be developed.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Marchand WR,Lee JN,Thatcher JW,Hsu EW,Rashkin E,Suchy Y,Chelune G,Starr J,Barbera SSdoi
10.1097/WNR.0b013e328302c873subject
Has Abstractpub_date
2008-06-11 00:00:00pages
957-60issue
9eissn
0959-4965issn
1473-558Xpii
00001756-200806110-00011journal_volume
19pub_type
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