Abstract:
:The effect of huperzine A (HupA) on oxygen-glucose deprivation (OGD)-induced injury was investigated in the rat pheochromocytoma cell line PC12. OGD for 3 h and reoxygenation for 24 h triggered apoptosis characterized by chromatin condensation, nucleus fragmentation and DNA laddering. The temporal profile of c-jun, p53, bcl-2 and bax mRNA after OGD indicated that these genes played important roles in apoptosis. Pre-incubation of the cells for 2 h with 1 microM HupA significantly attenuated apoptosis. The same treatment also reduced the up-regulation of c-jun and bax as well as the down-regulation of bcl-2. These data suggest the ability of HupA to attenuate apoptosis induced by OGD may result from its capability to alter the expression of apoptosis-related genes.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Zhou J,Fu Y,Tang XCdoi
10.1097/00001756-200107200-00007subject
Has Abstractpub_date
2001-07-20 00:00:00pages
2073-7issue
10eissn
0959-4965issn
1473-558Xjournal_volume
12pub_type
杂志文章相关文献
NEUROREPORT文献大全abstract::Mammals react to acute hypoxia with an initial augmentation and a secondary depression of the respiratory rhythm generated by brain stem neuronal networks. To investigate the cytosolic level of energy rich phosphorus metabolites during these responses, we developed 31P nuclear magnetic resonance spectroscopy of the br...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Transgenic mouse strains were generated that overexpress human APP or clinical mutants of APP. All transgenic mouse strains that over-express APP displayed essentially the same phenotype of disturbed behaviour, differential glutamatergic responses, deficits in maintenance of long-term potentiation and premature death,...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199811160-00004
更新日期:1998-11-16 00:00:00
abstract::Absence seizures are known to originate from disruptions within the corticothalamocortical network; however, the precise underlying cellular and molecular mechanisms that induce hypersynchronicity and hyperexcitability are debated and likely to be complex and multifactorial. Recent studies implicate impaired thalamic ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000909
更新日期:2017-12-13 00:00:00
abstract::Dopamine D2 receptor (D2R) signalling is implicated in limbic seizure propagation and seizure-induced neurodegeneration. D2R-/- mice display increased susceptibility to kainic acid (KA) seizures and seizure-induced apoptosis of hippocampal neurons. Here we further investigated the molecular pathways of KA-induced apop...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32833d5891
更新日期:2010-08-23 00:00:00
abstract::The Stroop effect refers to an increase in response time observed when the word meaning and the stimulus hue do not match. In an incongruent condition, the word 'green' is presented in the color red, whereas in a congruent condition the word 'red' is presented in the color red. To determine at what level of processing...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a0a10
更新日期:2009-05-06 00:00:00
abstract::It has been suggested that high levels of prenatal testosterone exposure are implied in the aetiology of dyslexia and its frequently co-occurring sensory problems. This study examined 2D : 4D digit ratio (a marker of fetal testosterone exposure) in dyslexic and normal reading children. No group differences in 2D : 4D ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3282e9a754
更新日期:2007-09-17 00:00:00
abstract::Voltage-gated ionic current and the response to quinine were studied on the four types of morphologically identified taste cells of the bullfrog fungiform papilla by whole-cell patch clamp recording with a Lucifer yellow-filled pipette. Dye-coupled type Ia cells (mucous cells) did not show voltage-activated currents. ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200109170-00040
更新日期:2001-09-17 00:00:00
abstract::Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affecting polypeptide s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200011090-00033
更新日期:2000-11-09 00:00:00
abstract::The aim of the study was to investigate differences in the distribution of intranasal trigeminal receptors in humans using an electrophysiological measure of trigeminally induced activation, the negative mucosa potential. A total of 29 young, healthy volunteers participated, results were on the basis of data from 18 p...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/01.wnr.0000224764.61959.e8
更新日期:2006-09-18 00:00:00
abstract::The present study investigated the effect of lexical competition on the time course of spoken word recognition in Mandarin Chinese using a unimodal auditory priming paradigm. Two kinds of competitive environments were designed. In one session (session 1), only the unrelated and the identical primes were presented befo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000492
更新日期:2016-01-20 00:00:00
abstract::Sirtuin 2 (SIRT2) is a member of the sirtuin family. Previous studies have suggested that SIRT2 mediates the cell death in models of Parkinson's disease and Huntington's disease. However, the role of SIRT2 in oxidative stress-induced cell death has remained unclear. In this study, we investigated the roles of SIRT2 in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000000192
更新日期:2014-08-06 00:00:00
abstract::The existence of a CRF-dependent inhibition of GnRH transcription was investigated using a neuronal GnRH-expressing cell line (Gn11) stably transfected with mouse (-611 bp) or chicken (-3000 bp) GnRH promoter/luciferase reporter constructs. The presence of the CRF-R1 receptor was established using a specific CRF-R1 an...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810050-00003
更新日期:1998-10-05 00:00:00
abstract::We aimed to ascertain whether pyrethroid insecticides could influence the vesicular transport of the excitatory amino acid glutamate. The incubation of rat cortical synaptic vesicles with resmethrin and permethrin, consistently stimulated both ATP-dependent and -independent uptake of [3H]glutamate, while not evoking d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199810260-00034
更新日期:1998-10-26 00:00:00
abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283186bf8
更新日期:2008-11-19 00:00:00
abstract::The role of the medial septum in suppressing paradoxical sleep and promoting slow wave sleep was suggested on the basis of neurotoxic lesion studies. However, these conclusions need to be substantiated with further experiments, including chemical stimulation studies. In this report, the medial septum was stimulated in...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283533692
更新日期:2012-05-09 00:00:00
abstract::Distracted driving remains a leading factor in fatal motor vehicle crashes, particularly in young drivers. Due to ongoing neuromaturation, attention capabilities are changing and improving throughout young adulthood. Here, we sought to bridge neuroscience with driving simulation by evaluating the effects of driving on...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001451
更新日期:2020-05-22 00:00:00
abstract::The hypothesis that reactive free radical species (ROS) may contribute to the pathogenesis of Duchenne muscular dystrophy (DMD) has been suggested previously, but experimental data obtained in support of the above have to date proved inconclusive. The recent discovery that nitric oxide synthase (required for muscle re...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199612200-00070
更新日期:1996-12-20 00:00:00
abstract::Newly hatched domestic chicks serve as an important model for experimental studies of neural and behavioral plasticity. Brain-derived neurotrophic factor (BDNF) has been shown to play a critical role in synaptic plasticity, including long-term potentiation, which underlies learning and memory in rodents. Here we show ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32834d0be7
更新日期:2011-12-07 00:00:00
abstract::The temporal lobe regions involved in memory retrieval were examined using fMRI. During an associative recognition test, participants made memory judgments about the study color of previously presented drawings of objects, and during item recognition tests they made old/new judgments about previously studied objects o...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200102120-00035
更新日期:2001-02-12 00:00:00
abstract::ONO-1714, a selective inhibitor of inducible nitric oxide synthetase (iNOS) attenuated the increase of apoptosis and improved the functional outcome of urinary bladder after traumatic spinal cord injury. These findings suggest that iNOS plays a role in the process of SCI. Early treatment with 30 mg/kg methylprednisolo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200409150-00021
更新日期:2004-09-15 00:00:00
abstract::Neurons respond to extracellular stimulation by modulating the expression of certain immediate-early genes. Inducible transcription factors (ITFs), such as c-Fos and Zif268, are coded by this class of gene and are among the first proteins to appear. The rapid accumulation of these products combined with histological m...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-08 00:00:00
abstract:OBJECTIVE:Cervical spondylotic myelopathy is regarded as a chronic, special incomplete spinal cord injury, so the sensory components transmitted to thalamus decreased after distal spinal cord injury, which lead the disturbance of thalamus-cortex circuits, which might explain the alterations of clinical function of cerv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001346
更新日期:2020-03-25 00:00:00
abstract::Spinal cord injury (SCI) causes motor dysfunction and depression, which hinders the recovery of motor function. Body weight-supported treadmill training (BWSTT) should be considered an effective method for functional rehabilitation after SCI, as it is an efficacious intervention in healthcare with no side effects. Bec...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0000000000001543
更新日期:2020-12-16 00:00:00
abstract::The neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and transported into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Recently it has been reported that the entire coding region of VAChT mRNA is located in the first intron of the ChAT gene. In this study, ChAT...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199505090-00004
更新日期:1995-05-09 00:00:00
abstract::Functional MRI (fMRI) can detect changes from resting levels of blood flow and oxygenation during task performance (i.e. activation). We used a simple electrical nerve stimulation technique together with fMRI to study pain process in the human cortex. Images of the primary somatosensory (SI) and cingulate cortex (Cg) ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:
更新日期:1995-12-29 00:00:00
abstract::Both extracellular guanosine and adenosine stimulated astrocyte proliferation in vitro and increased intracellular cAMP 6-fold within 2 min. The effects of both guanosine and adenosine on proliferation and cAMP levels were inhibited by antagonists of adenosine A2 receptors but augmented by A1 receptor antagonists. The...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199111000-00007
更新日期:1991-11-01 00:00:00
abstract::The amyloid cascade hypothesis suggests that amyloid precursor protein (APP) proteolytic processing is a key event in the pathogenesis of Alzheimer's disease (AD). The enzymes beta-site APP cleaving enzyme (BACE) and A disintegrin and metalloproteinase 10 (ADAM10) play an important role in APP proteolysis. We measured...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200211150-00008
更新日期:2002-11-15 00:00:00
abstract::The aim of this study was to investigate whether the DNA methylation pattern within the alpha synuclein promoter region is altered in intoxicated and early abstinence patients with alcoholism undergoing alcohol withdrawal. We observed a significant increase of the alpha synuclein promoter DNA methylation in patients w...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-200502080-00020
更新日期:2005-02-08 00:00:00
abstract::The pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGFbeta). In normal control retinas, intense immunostaining of APP and B...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199902250-00012
更新日期:1999-02-25 00:00:00
abstract::In the anaesthetized rat, low frequency electrical stimulation of the Zusanli acupoint (S36) or noxious thermal stimulation caused by immersing the footpad in water at 52 degrees C caused marked expression of c-fos in the anterior lobe of the pituitary gland, as well as in the arcuate and some nearby hypothalamic nucl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/00001756-199408150-00027
更新日期:1994-08-15 00:00:00