Abstract:
:In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we constructed a chimeric receptor, in which the extracellular domain of the receptor for colony-stimulating factor-1 was fused to the cytoplasmic domain of LTK, which allowed the selective activation of LTK by colony-stimulating factor-1. Our studies using this chimeric receptor suggest that activation of the tyrosine kinase activity of LTK is sufficient to promote neurite outgrowth through pathways that include reactions catalyzed by phosphatidylinositol 3-kinase and MAPK.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Yamada S,Nomura T,Takano K,Fujita S,Miyake M,Miyake Jdoi
10.1097/WNR.0b013e3283186bf8subject
Has Abstractpub_date
2008-11-19 00:00:00pages
1733-8issue
17eissn
0959-4965issn
1473-558Xjournal_volume
19pub_type
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