The influence of nodal constriction on conduction velocity in myelinated nerve fibers.

Abstract:

:Myelinated nerve fibers exhibit a complex anatomy in the nodal region which includes a marked nodal-paranodal constriction and an intricate paranodal structure where the myelin sheath is separated from the axon by a narrow periaxonal space. In this study, a recently developed computational model of the mammalian myelinated nerve fiber based on electron microscopic data was employed to examine the effect of the nodal-paranodal axonal radius and periaxonal space width on the conduction of action potentials. These findings indicate that the nodal-paranodal constriction promotes higher conduction velocities by minimizing the component of the nodal capacity contributed by the paranodal axolemma. Model prediction of optimal nodal-paranodal radii is correlated with radii determined in experimental anatomical studies.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Halter JA,Clark JW Jr

doi

10.1097/00001756-199301000-00023

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

89-92

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

4

pub_type

杂志文章
  • Regulation of vasoactive intestinal polypeptide release in the suprachiasmatic nucleus circadian clock.

    abstract::Timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina. Retinorecipient units entrain rhythmicity of SCN pacemaker cells in part through their release of vasoactive intestinal polypeptide (VIP). The underlying nature of this process is conjectural, how...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833fcba4

    authors: Francl JM,Kaur G,Glass JD

    更新日期:2010-11-17 00:00:00

  • Beta-frequency EEG activity increased during transcranial direct current stimulation.

    abstract::Transcranial direct current stimulation (tDCS) is a technique for noninvasively stimulating specific cortical regions of the brain with small (<2 mA) and constant direct current on the scalp. tDCS has been widely applied, not only for medical treatment, but also for cognitive and somatosensory function enhancement, mo...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000283

    authors: Song M,Shin Y,Yun K

    更新日期:2014-12-17 00:00:00

  • The representation of articulation in the primary sensorimotor cortex.

    abstract::Bilabial, alveolar and velar sounds are produced at different locations around the oral cavity. fMRI was used to localize cortical representation of articulation in seven healthy subjects during repetitive lip and vertical tongue movements as well as repetitive articulation of /pa/ (bilabial), /ta/ (alveolar), /ka/ (v...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200009110-00032

    authors: Lotze M,Seggewies G,Erb M,Grodd W,Birbaumer N

    更新日期:2000-09-11 00:00:00

  • ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation.

    abstract::Apolipoprotein E (apoE) and the beta-amyloid peptide are both found in the senile plaques associated with Alzheimer's disease. Several studies have recently determined that apoE can prevent beta-amyloid fibril (Abetaf) formation in vitro. In vivo, apoE is normally associated with a lipid source. We show that both reco...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00031

    authors: Beffert U,Poirier J

    更新日期:1998-10-05 00:00:00

  • Visuomotor adaptation during inactivation of the dentate nucleus.

    abstract::Recent experiments have suggested that the process of visuomotor adaptation depends on how a visual distortion is introduced. The cerebellum is thought to be involved in adapting to rapidly introduced visual distortions; however its role in adapting to a gradually introduced distortion is unknown. We tested adaptation...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199904060-00025

    authors: Robertson EM,Miall RC

    更新日期:1999-04-06 00:00:00

  • Responses from new receptive fields of VPL neurones following deafferentation.

    abstract::Single unit recordings were made from the ventral posterior lateral thalamus of anaesthetized rats to characterize responses to the activation of new receptive fields induced by either local anaesthesia or amputation. Receptive fields confined to single digits were identified and evoked unit responses to the stimulati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:

    authors: Shin HC,Park S,Son J,Sohn JH

    更新日期:1995-12-29 00:00:00

  • Resiliency of cortical neural networks against cascaded failures.

    abstract::Network tools have been extensively applied to study the properties of brain functional and anatomical networks. In this paper, resiliency of Caenorhabditis elegans cortical networks against cascaded failures is studied. To this end, directed network formed by chemical connections and undirected network formed by elec...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000421

    authors: Jalili M

    更新日期:2015-08-19 00:00:00

  • Moyamoya patients exhibit higher brain temperatures than normal controls.

    abstract::The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32833d6b7a

    authors: Yamada K,Sakai K,Akazawa K,Yuen S,Sugimoto N,Sasajima H,Mineura K,Nishimura T

    更新日期:2010-09-15 00:00:00

  • Pattern of distribution and co-localization of NOS and ATP in the myenteric plexus of human fetal stomach and intestine.

    abstract::The pattern of distribution and co-localization of nitric oxide synthase (NOS) and quinacrine fluorescence (indicative of vesicular adenosine 5'-triphosphate, ATP), and co-localization of NADPH-diaphorase (NADPH-d) activity and NOS-immunoreactivity in the myenteric plexus of pre-term human fetal (6-17 weeks of gestati...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200001170-00002

    authors: Belai A,Burnstock G

    更新日期:2000-01-17 00:00:00

  • Cortical activation changes associated with motor recovery in patients with precentral knob infarct.

    abstract::We investigated the cortical activation changes associated with motor recovery in six hemiparetic patients with precentral knob infarct. fMRI at 1.5 T with finger movements at a fixed rate was performed twice in each patient, 1 and 6 months after stroke onset. From the images obtained, the LI (laterality index) for th...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200403010-00002

    authors: Jang SH,Cho SH,Kim YH,Kwon YH,Byun WM,Lee SJ,Park SM,Chang CH

    更新日期:2004-03-01 00:00:00

  • N-linked glycosylation of cortical N-methyl-D-aspartate and kainate receptor subunits in schizophrenia.

    abstract::Dysfunctional glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia. Abnormal expressions in schizophrenia of ionotropic glutamate receptors (iGluRs) and the proteins that regulate their trafficking have been found to be region and subunit specific in brain, suggesting that abnormal t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e328363bd8a

    authors: Tucholski J,Simmons MS,Pinner AL,McMillan LD,Haroutunian V,Meador-Woodruff JH

    更新日期:2013-08-21 00:00:00

  • Transneuronal viral labelling of rat heart left ventricle controlling pathways.

    abstract::Retrograde transneuronal viral labelling and immunocytochemical methods were used for revealing neuronal networks controlling the left ventricle myocardium of the rat heart. After injections of 1 microliter pseudorabies virus solution (3 x 10(6) PFU ml-1) into the left ventricle, infected orthosympathetic preganglioni...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199309150-00005

    authors: Ter Horst GJ,Van den Brink A,Homminga SA,Hautvast RW,Rakhorst G,Mettenleiter TC,De Jongste MJ,Lie KI,Korf J

    更新日期:1993-09-30 00:00:00

  • Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.

    abstract::DNA methylation is important for controlling gene expression and is catalyzed by DNA methyltransferase (Dnmt1) an enzyme abundant in brain. We recently demonstrated that mice expressing reduced levels of Dnmt1 are protected from cerebral ischemia. Here, we used the cre/loxP system to produce conditional mutants that l...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112040-00032

    authors: Endres M,Fan G,Meisel A,Dirnagl U,Jaenisch R

    更新日期:2001-12-04 00:00:00

  • Role of human frontal and supplementary eye fields in double step saccades.

    abstract::Transcranial magnetic stimulation (TMS) was applied over the frontal eye field (FEF) and the supplementary eye field (SEF) regions before execution of the first saccade in a double step task. When applied over the FEF, stimulation increased the percentage error in amplitude of the contralateral second saccade as compa...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200202110-00016

    authors: Tobler PN,Müri RM

    更新日期:2002-02-11 00:00:00

  • When mirroring is not enough: that is, when only a complementary action will do (the trick).

    abstract::It is well known that perceiving another person's body movements activates corresponding motor representations in an observer's brain, a process which appears to be imitative in nature. However, it is also true that simply imitating another person's action/s in many situations is not an effective or appropriate respon...

    journal_title:Neuroreport

    pub_type: 杂志文章,评审

    doi:10.1097/WNR.0b013e3283630a66

    authors: Sartori L,Betti S,Castiello U

    更新日期:2013-08-07 00:00:00

  • Effects of phenytoin on the persistent Na+ current of mammalian CNS neurones.

    abstract::Whole-cell recordings in voltage-clamp mode were performed on acutely isolated neurones from rat neocortex and neostriatum to examine the effects of the anticonvulsant phenytoin on a non-inactivating (persistent) Na+ current (INaP). INaP was chosen because it enhances neuronal excitability near firing threshold, which...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199509000-00017

    authors: Chao TI,Alzheimer C

    更新日期:1995-09-11 00:00:00

  • Differential expression patterns of mGluR1 alpha in monkey nigral dopamine neurons.

    abstract::The expression pattern of metabotropic glutamate receptor 1alpha (mGluR1alpha) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1alpha immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) wher...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000074344.81633.e4

    authors: Kaneda K,Imanishi M,Nambu A,Shigemoto R,Takada M

    更新日期:2003-05-23 00:00:00

  • The impact of emotional involvement on online service buying decisions: an event-related potentials perspective.

    abstract::When examining a buying process, changes in human brain signals and their event-related potential (ERP) components can be considered a reflection of the consumers' emotions. In this experiment, participants were shown 12 products and related services that were available for purchase. After recording ERP components, we...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000457

    authors: Zhao M,Wang J,Han W

    更新日期:2015-12-02 00:00:00

  • Glutamine's protection against brain damage in septic rats via increased protein oxygen-N-acetylglucosamine modification.

    abstract:OBJECTIVE:This study aimed to observe the effect of glutamine (Gln) on brain damage in septic rats and explore its possible mechanism. METHODS:Ninety-three Sprague-Dawley rats were randomly divided into five groups: sham operation group, sepsis group, Gln-treated group, quercetin/Gln-treated group, and alloxan/Gln-tre...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001582

    authors: Wang J,Lu X,Zheng K,Jing L

    更新日期:2021-01-18 00:00:00

  • Effects of bFGF and TGFbeta on the expression of amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina.

    abstract::The pattern of immunoreactivity for amyloid precursor (APP) and B-cell lymphoma protooncogene (Bcl-2) proteins in the rat retina was studied after intravitreal injection of basic fibroblast growth factor (bFGF) or transforming growth factor-beta (TGFbeta). In normal control retinas, intense immunostaining of APP and B...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199902250-00012

    authors: Chen ST,Jen A,Gentleman SM,Jen LS

    更新日期:1999-02-25 00:00:00

  • Phenylketonuria-related synaptic changes in a BTBR-Pah(enu2) mouse model.

    abstract::Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283495acc

    authors: Liang L,Gu X,Lu L,Li D,Zhang X

    更新日期:2011-08-24 00:00:00

  • Effect of transcranial direct current stimulation on vestibular-ocular and vestibulo-perceptual thresholds.

    abstract::Transcranial direct current stimulation (tDCS) was used in 17 normal individuals to modulate vestibulo-ocular reflex (VOR) and self-motion perception rotational thresholds. The electrodes were applied over the temporoparietal junction bilaterally. Both vestibular nystagmic and perceptual thresholds were increased duri...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3283646e65

    authors: Kyriakareli A,Cousins S,Pettorossi VE,Bronstein AM

    更新日期:2013-10-02 00:00:00

  • Differential expression of transcription factors in the accumbens of an animal model of ADHD.

    abstract::Transcription factors have been used as neuronal markers in the nucleus accumbens (ACB) of male juvenile spontaneously hypertensive rats (SHR), an animal model of attention-deficit hyperactivity disorder (ADHD), to trace putative neural substrates. In SHR, immunocytochemistry and PC-assisted image analysis showed lowe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199705060-00011

    authors: Papa M,Sergeant JA,Sadile AG

    更新日期:1997-05-06 00:00:00

  • Enhanced phosphorylation of S6 protein in mouse cortical layer V and subplate neurons.

    abstract::The mammalian neocortex is composed of six major layers of neurons. Each group of neurons in the cortical layers has distinct characteristics based on the expression of specific genes and connectivity patterns of neural circuits. Neuronal subtype transition and regional identity acquisition are established by temporal...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001479

    authors: Lee SE,Hwang S,Ahn SG,D'Arcangelo G,Lee GH

    更新日期:2020-07-10 00:00:00

  • Microglial signaling by amyloid beta protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS.

    abstract::Myristoylated alanine-rich C kinase substrate (MARCKS), an acidic protein associated with cell motility and phagocytosis, is activated upon phosphorylation by protein kinase C (PKC) and proline-directed protein kinases. In Alzheimer disease (AD), activated microglia expressing MARCKS migrates around senile plaques. We...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200108080-00055

    authors: Hasegawa H,Nakai M,Tanimukai S,Taniguchi T,Terashima A,Kawamata T,Fukunaga K,Miyamoto E,Misaki K,Mukai H,Tanaka C

    更新日期:2001-08-08 00:00:00

  • Botulinum toxin type A reduces the expression of transient receptor potential melastatin 3 and transient receptor potential vanilloid type 4 in the trigeminal subnucleus caudalis of a rat model of trigeminal neuralgia.

    abstract::This study was designed to investigate the expression of transient receptor potential melastatin 3 (TRPM3) and transient receptor potential vanilloid type 4 (TRPV4) in the trigeminal spinal subnucleus caudalis of a rat model of trigeminal neuralgia (TN). The influence of botulinum toxin type A (BTX-A) on the expressio...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001268

    authors: Zhang Y,Su Q,Lian Y,Chen Y

    更新日期:2019-07-03 00:00:00

  • Brain regions supporting intentional and incidental memory: a PET study.

    abstract::Regional brain activity associated with intentional and incidental memory retrieval was studied with PET. Previously studied and new words were presented in either an intentional or an incidental memory task. Type of task was crossed with an encoding manipulation ('deep' vs 'shallow') which varied the probability that...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/00001756-199703240-00045

    authors: Rugg MD,Fletcher PC,Frith CD,Frackowiak RS,Dolan RJ

    更新日期:1997-03-24 00:00:00

  • Huperzine A, a novel promising acetylcholinesterase inhibitor.

    abstract::The effects of huperzine A on memory impairments induced by scopolamine were evaluated using a radial maze task and inhibition of cholinesterase in vitro compared with the effects of E2020 and tacrine. Scopolamine (0.2 mg kg-1) significantly impaired spatial memory in rats. Huperzine A (0.1-0.4 mg kg-1, p.o.), E2020 (...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199612200-00020

    authors: Cheng DH,Ren H,Tang XC

    更新日期:1996-12-20 00:00:00

  • Fluoxetine-induced regulation of heat shock protein 90 and 14-3-3ε in human embryonic carcinoma cells.

    abstract::Fluoxetine, a serotonin-selective reuptake inhibitor, exerts antidepressant and antianxiety effects on major depressive and anxiety disorders. Previous studies suggest that treatment with fluoxetine influences the expression of various proteins that are involved in proliferation, differentiation, and apoptosis in the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000284

    authors: Oh D,Choi MR,Han DM,Chai YG,Choi J

    更新日期:2014-12-03 00:00:00

  • Caffeine exposure sensitizes rats to the reinforcing effects of cocaine.

    abstract::The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to coca...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199101000-00013

    authors: Horger BA,Wellman PJ,Morien A,Davies BT,Schenk S

    更新日期:1991-01-01 00:00:00