Abstract:
:The expression pattern of metabotropic glutamate receptor 1alpha (mGluR1alpha) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1alpha immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) where calbindin-D28k-containing dopaminergic neurons invulnerable to parkinsonian degeneration are specifically located. On the other hand, mGluR1alpha was strongly expressed in the ventral tier of the substantia nigra pars compacta (SNc-v). In monkeys treated with the parkinsonism-inducing drug, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mGluR1alpha expression was decreased in dopaminergic neurons in the SNc-v that were spared its toxic action. These results suggest that mGluR1alpha expression may be involved at least partly in the vulnerability of dopaminergic neurons to parkinsonian insults.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Kaneda K,Imanishi M,Nambu A,Shigemoto R,Takada Mdoi
10.1097/01.wnr.0000074344.81633.e4subject
Has Abstractpub_date
2003-05-23 00:00:00pages
947-50issue
7eissn
0959-4965issn
1473-558Xjournal_volume
14pub_type
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