Differential expression patterns of mGluR1 alpha in monkey nigral dopamine neurons.

Abstract:

:The expression pattern of metabotropic glutamate receptor 1alpha (mGluR1alpha) was immunohistochemically investigated in substantia nigra dopaminergic neurons of the macaque monkey. In normal monkeys, mGluR1alpha immunoreactivity was weakly observed in the dorsal tier of the substantia nigra pars compacta (SNc-d) where calbindin-D28k-containing dopaminergic neurons invulnerable to parkinsonian degeneration are specifically located. On the other hand, mGluR1alpha was strongly expressed in the ventral tier of the substantia nigra pars compacta (SNc-v). In monkeys treated with the parkinsonism-inducing drug, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mGluR1alpha expression was decreased in dopaminergic neurons in the SNc-v that were spared its toxic action. These results suggest that mGluR1alpha expression may be involved at least partly in the vulnerability of dopaminergic neurons to parkinsonian insults.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Kaneda K,Imanishi M,Nambu A,Shigemoto R,Takada M

doi

10.1097/01.wnr.0000074344.81633.e4

subject

Has Abstract

pub_date

2003-05-23 00:00:00

pages

947-50

issue

7

eissn

0959-4965

issn

1473-558X

journal_volume

14

pub_type

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