Abstract:
:The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to cocaine's reinforcing effects was accompanied by an increase in the neurochemical response of the mesolimbic dopamine system to an acute injection of cocaine (10 mg kg-1, i.p.) as measured by in vivo microdialysis. Thus, the data suggest that exposure to caffeine can increase the reinforcing effects of cocaine, possibly via an enhanced response to the mesolimbic dopamine system.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Horger BA,Wellman PJ,Morien A,Davies BT,Schenk Sdoi
10.1097/00001756-199101000-00013subject
Has Abstractpub_date
1991-01-01 00:00:00pages
53-6issue
1eissn
0959-4965issn
1473-558Xjournal_volume
2pub_type
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