Caffeine exposure sensitizes rats to the reinforcing effects of cocaine.

Abstract:

:The present study examined the effect of pre-exposure to a moderate dose of caffeine (20 mg kg-1) on the acquisition of self-administration of cocaine (0.125 mg kg-1/infusion or 0.25 mg kg-1/infusion) in the rat. Rats pre-exposed to caffeine acquired self-administration more rapidly. Furthermore, sensitization to cocaine's reinforcing effects was accompanied by an increase in the neurochemical response of the mesolimbic dopamine system to an acute injection of cocaine (10 mg kg-1, i.p.) as measured by in vivo microdialysis. Thus, the data suggest that exposure to caffeine can increase the reinforcing effects of cocaine, possibly via an enhanced response to the mesolimbic dopamine system.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Horger BA,Wellman PJ,Morien A,Davies BT,Schenk S

doi

10.1097/00001756-199101000-00013

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

53-6

issue

1

eissn

0959-4965

issn

1473-558X

journal_volume

2

pub_type

杂志文章
  • Pulsed radio frequency radiation affects cognitive performance and the waking electroencephalogram.

    abstract::We investigated the effects of radio frequency electromagnetic fields on brain physiology. Twenty-four healthy young men were exposed for 30 min to pulse-modulated or continuous-wave radio frequency electromagnetic fields (900 MHz; peak specific absorption rate 1 W/kg), or sham exposed. During exposure, participants p...

    journal_title:Neuroreport

    pub_type: 临床试验,杂志文章

    doi:10.1097/WNR.0b013e3280d9435e

    authors: Regel SJ,Gottselig JM,Schuderer J,Tinguely G,Rétey JV,Kuster N,Landolt HP,Achermann P

    更新日期:2007-05-28 00:00:00

  • Do loudness cues contribute to duration mismatch negativity reduction in schizophrenia?

    abstract::The present study explored duration mismatch negativity (MMN) reduction in schizophrenia. Duration MMN studies usually employ tones of very short duration (< 200 ms). For stimuli < 200 ms in duration, an increment in duration is accompanied by an increase in perceived loudness. It was previously proposed that the effe...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200112210-00042

    authors: Todd J,Michie PT,Jablensky AV

    更新日期:2001-12-21 00:00:00

  • N- and C-terminal substance P fragments: differential effects on striatal [3H]substance P binding and NK1 receptor internalization.

    abstract::N- and C-terminal substance P (SP) fragments increase striatal dopamine outflow at nanomolar concentrations. This contrasts with their low affinity for NK1 receptors. To explore this discrepancy, we investigated the interaction of SP and SP fragments with NK1 sites in fresh striatal slices, the same model used in the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199907130-00038

    authors: Michael-Titus AT,Blackburn D,Connolly Y,Priestley JV,Whelpton R

    更新日期:1999-07-13 00:00:00

  • Dendrobium nobile Lindl. polysaccharides reduce cerebral ischemia/reperfusion injury in mice by increasing myeloid cell leukemia 1 via the downregulation of miR-134.

    abstract:OBJECTIVE:The traditional Chinese medicine, Dendrobium nobile Lindl. polysaccharides (DNLP), reportedly has neuroprotective effects. However, its effects following ischemic stroke remain unclear. This study aimed to explore the role and mechanism of DNLP in experimental models of inflammation and apoptosis. METHODS:In...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000001562

    authors: Liu J,Han Y,Zhu T,Yang Q,Wang H,Zhang H

    更新日期:2020-12-14 00:00:00

  • Cortical categorization failure in 2-month-old infants at risk for dyslexia.

    abstract::Cortical auditory categorization was assessed in 2-month-old infants at genetic risk for dyslexia and controls. Manipulated /bAk/ and /dAk/ speech stimuli were used as frequently presented standards. The neuroelectric brain responses of the control infants were highly sensitive to the phoneme boundary that separated t...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e3280c1e2bf

    authors: van Leeuwen T,Been P,van Herten M,Zwarts F,Maassen B,van der Leij A

    更新日期:2007-06-11 00:00:00

  • In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand.

    abstract::5-[125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([125I]5-I-A-85380) was evaluated in the mouse as a potential in vivo imaging ligand for central nicotinic acetylcholine receptors (nAChRs). After i.v. administration of [125I]5-I-A-85380, peak brain levels of radioactivity were measured within 1 h and declined slowly ov...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199807130-00030

    authors: Vaupel DB,Mukhin AG,Kimes AS,Horti AG,Koren AO,London ED

    更新日期:1998-07-13 00:00:00

  • Human thalamus: neurochemical mapping of inferior pulvinar complex.

    abstract::The primate pulvinar connects with the entire array of known visual areas and is postulated to play a role in selective visual attention. Recently, five separate neurochemical subdivisions of a region termed the inferior pulvinar (PI) complex were identified in monkeys. In the present study, similar histochemical proc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199912160-00002

    authors: Cola MG,Gray DN,Seltzer B,Cusick CG

    更新日期:1999-12-16 00:00:00

  • CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats.

    abstract::The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell de...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/01.wnr.0000133298.84901.cf

    authors: Borlongan CV,Skinner SJ,Geaney M,Vasconcellos AV,Elliott RB,Emerich DF

    更新日期:2004-07-19 00:00:00

  • 192 IgG-saporin abolishes p75 neurotrophin receptor immunoreactivity in rat SCN.

    abstract::The rat suprachiasmatic (SCN) contains a dense plexus of low-affinity p75 neurotrophin receptor (p75NTR)-immunoreactivity. In some SCN neurons, p75NTR is co-localized with vasoactive intestinal peptide (VIP). The present study examines the effect of third ventricle administration of 192 IgG-saporin immunotoxin on p75N...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199810050-00012

    authors: Moga MM

    更新日期:1998-10-05 00:00:00

  • GABAergic mechanisms gate tactile discrimination learning.

    abstract::In contrast to mechanisms mediating synaptic plasticity, the pharmacological basis of perceptual learning remains to be clarified. Here we report that a specific form of perceptual learning is influenced by GABAergic mechanisms. We induced perceptual learning by Hebbian co-activation of the skin of the tip of the righ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200309150-00018

    authors: Dinse HR,Ragert P,Pleger B,Schwenkreis P,Tegenthoff M

    更新日期:2003-09-15 00:00:00

  • Non-frontal P3b-like activity evoked by the Wisconsin Card Sorting Test.

    abstract::Event related potentials (ERP) were recorded from 29 electrode positions in 10 normal subjects while they performed a simplified version of the Wisconsin Card Sorting Test (WCST). The design focused on ERP differences between early and late trials within each WCST series. Topographic and dipole analyses confirmed the ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199803090-00034

    authors: Barceló F,Rubia FJ

    更新日期:1998-03-09 00:00:00

  • Rotation-induced conditioned rejection in the taste reactivity test.

    abstract::The taste reactivity test was used to evaluate the ability of motion sickness to produce conditioned rejection reactions, a putative measure of nausea in rats. Following three conditioning trials, rats displayed conditioned rejection reactions during an intraoral infusion of a rotation-paired saccharin solution. This ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199905140-00030

    authors: Cordick N,Parker LA,Ossenkopp KP

    更新日期:1999-05-14 00:00:00

  • MRI of subacute hemorrhagic transformation in the rat suture occlusion model.

    abstract::In this study we investigated the utility of different MRI techniques for the detection and predictability of hemorrhagic transformation (HT) in a rat model of transient focal cerebral ischemia. Hemorrhagic infarction was reliably identified with gradient-echo sequences and developed between 2 and 7 days following the...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200102120-00025

    authors: Neumann-Haefelin T,Kastrup A,de Crespigny A,Ringer TM,Sun GH,Yenari MA,Moseley ME

    更新日期:2001-02-12 00:00:00

  • Noradrenergic inputs enhance the response of neurosecretory cells to osmotic stimulation.

    abstract::Extracellular recordings from neurosecretory cells in the hypothalamic paraventricular nucleus (PVN) displayed either an excitation or no response following electrical stimulation (5 Hz) of the A1 noradrenergic region of the ventrolateral medulla, and exhibited either an increase or no effect in neuronal activity in r...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199203000-00010

    authors: Tanaka J,Nomura M,Saito H

    更新日期:1992-03-01 00:00:00

  • Kinematic features of passive forelimb movements and rat cuneate neuron discharges.

    abstract::We examined the role of main and external cuneate nuclei neurons in processing sensory information during forelimb passive movement. We recorded activity of neurons using circular and figure-eight trajectories, at different speeds, in anaesthetized rats. A multivariate regression analysis was performed to correlate ne...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200203040-00004

    authors: Garifoli A,Caserta C,Bosco G,Lombardo SA,Casabona A,Perciavalle V

    更新日期:2002-03-04 00:00:00

  • Perception and recognition discriminated in the mouse auditory cortex by c-Fos labeling.

    abstract::The functions of the fields of the mammalian auditory cortex in sound perception and recognition are unknown. We used Fos (a protein of the inducible immediate-early gene c-fos) as a cellular marker of activated brain areas to show in the mouse (Mus domesticus) that sound is processed differentially in auditory cortic...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199908020-00022

    authors: Fichtel I,Ehret G

    更新日期:1999-08-02 00:00:00

  • Altered protein mannosylation in developing cerebral cortex by streptomycin.

    abstract::Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affecting polypeptide s...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200011090-00033

    authors: Alperin MD,Calandria JM,Carminatti H,Idoyaga-Vargas VP

    更新日期:2000-11-09 00:00:00

  • Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors.

    abstract::To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid releas...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200210280-00026

    authors: Kolko M,de Turco EB,Diemer NH,Bazan NG

    更新日期:2002-10-28 00:00:00

  • Human area 5 modulates corticospinal output during movement preparation.

    abstract::Neuroimaging evidence suggests that human Brodmann area 5 (BA5) within the superior parietal lobule contributes to movement planning. However, a causal role for the contribution of BA5 to preparatory processes has yet to be reported. We used paired-pulse transcranial magnetic stimulation to investigate the influence o...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0000000000000655

    authors: Mackenzie TN,Bailey AZ,Mi PY,Tsang P,Jones CB,Nelson AJ

    更新日期:2016-09-28 00:00:00

  • Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study.

    abstract::Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patien...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200310060-00015

    authors: Sun Z,Wang F,Cui L,Breeze J,Du X,Wang X,Cong Z,Zhang H,Li B,Hong N,Zhang D

    更新日期:2003-10-06 00:00:00

  • Sleep-promoting activity of prolactin-releasing peptide (PrRP) in the rat.

    abstract::The present study examines whether or not prolactin-releasing peptide (PrRP) infused intracerebroventricularly (i.c.v.) affects sleep and the release of prolactin (PRL) and growth hormone (GH) in rats. At a dose of 0.1 nmol, PrRP promoted rapid-eye-movement (REM) sleep, whereas 1.0 nmol increased both non-REM and REM ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200110290-00006

    authors: Zhang SQ,Inoué S,Kimura M

    更新日期:2001-10-29 00:00:00

  • Attracting attention to the illusory location of a sound: reflexive crossmodal orienting and ventriloquism.

    abstract::Sound localization can be affected by vision; in the ventriloquism effect, sounds that are hard to localize within hearing become mislocalized toward the location of concurrent visual events. Here we tested whether spatial attention is drawn to the illusory location of a ventriloquized sound. The study exploited our p...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200006260-00049

    authors: Spence C,Driver J

    更新日期:2000-06-26 00:00:00

  • Effect of hypothermia on microglial reaction in ischemic brain.

    abstract::Intra-ischemic hypothermia is known to protect neurons against ischemic injury. Microglial cells have been shown to become activated following ischemia and are speculated to play significant roles in the evolution of ischemic neuronal injury. In this study, we examined the effect of intra-ischemic hypothermia on the m...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199703030-00026

    authors: Kumar K,Evans AT

    更新日期:1997-03-03 00:00:00

  • Down regulation of nestin by TGF-beta or serum in SFME cells accompanies differentiation into astrocytes.

    abstract::The serum-free mouse embryo (SFME) cell line, derived from 16-day-old mouse embryos in medium in which serum was replaced by growth factors and other supplements, has been cultured for more than 200 generations. SFME cells are nontumorigenic, lack gross chromosomal abnormalities, and display characteristics of CNS pro...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199408150-00011

    authors: Loo DT,Althoen MC,Cotman CW

    更新日期:1994-08-15 00:00:00

  • Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures.

    abstract::The neuroprotective effect of docosahexaenoic acid (DHA) on the glutamate-induced cytotoxicity in rat hippocampal cultures was investigated in the present study. DHA at 5-50 microg/ml successfully protected neurons against the cytotoxicity, markedly increased the cell viability, inhibited both nitric oxide (NO) produc...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200312190-00033

    authors: Wang X,Zhao X,Mao ZY,Wang XM,Liu ZL

    更新日期:2003-12-19 00:00:00

  • Domoic acid induces the release of glutamate in the rat hippocampal CA3 subregion.

    abstract::We investigated the role of kainate receptor activation in modulating the influx of Ca2+ coupled to the exocytotic release of glutamate in rat hippocampal synaptosomal fractions (P2). In whole hippocampus synaptosomes stimulation with domoic acid increased the intracellular free Ca2+ concentration ([Ca2+]i) in a dose-...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199605170-00023

    authors: Malva JO,Carvalho AP,Carvalho CM

    更新日期:1996-05-17 00:00:00

  • NADPH diaphorase-positive cells in the brain after status epilepticus.

    abstract::Using NADPH-diaphorase (NADPH-d) histochemistry, the expression of nitric oxide synthase (NOS) was studied in the rat brain 1 week after kainate-induced status epilepticus. Major changes were observed in the hippocampi of epileptic animals, especially a loss of NADPH-d positive fibres in the periphery of degenerative ...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199412000-00057

    authors: Lerner-Natoli M,de Bock F,Bockaert J,Rondouin G

    更新日期:1994-12-20 00:00:00

  • Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.

    abstract::To assess the effect of genetic factors on sporadic Parkinson disease, we performed a case-control study of a variant (G2385R) in Leucine-Rich Repeat kinase 2 among the Japanese population. The G2385R (c.7153G>A) variant was reported as a risk factor for sporadic Parkinson disease in the Chinese population from Taiwan...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/WNR.0b013e32801254b6

    authors: Funayama M,Li Y,Tomiyama H,Yoshino H,Imamichi Y,Yamamoto M,Murata M,Toda T,Mizuno Y,Hattori N

    更新日期:2007-02-12 00:00:00

  • A new aspect of aminoglycoside ototoxicity: impairment of cochlear dopamine release.

    abstract::Aminoglycoside ototoxicity is a well-documented process via several pathophysiological pathways. The protective role of cochlear dopamine, released from the lateral olivocochlear efferents, was implicated previously in case of ischemia or acoustic trauma, as it postsynaptically inhibits the effect of excessively relea...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-200110290-00036

    authors: Gáborján A,Halmos G,Répássy G,Vizi ES

    更新日期:2001-10-29 00:00:00

  • Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis.

    abstract::Both ice-like protease and calpain have been shown to be involved in apoptosis in non-neuronal cells. Cultured rat cerebellar granule neurons undergo apoptosis when exposed to low potassium-containing medium. Calpain inhibitors 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD150606) and N-acetyl-Leu-Leu-Met-CHO (c...

    journal_title:Neuroreport

    pub_type: 杂志文章

    doi:10.1097/00001756-199612200-00050

    authors: Nath R,Raser KJ,McGinnis K,Nadimpalli R,Stafford D,Wang KK

    更新日期:1996-12-20 00:00:00