Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis.

abstract：:To test the hypothesis that correlated neuronal activity serves as the neuronal code for visual feature binding, we applied information theory techniques to multiunit activity recorded from pairs of V1 recording sites in anaesthetised cats while presenting either single or separate bar stimuli. We quantified the roles...

journal_title：Neuroreport

authors： Golledge HD,Panzeri S,Zheng F,Pola G,Scannell JW,Giannikopoulos DV,Mason RJ,Tovée MJ,Young MP

更新日期：2003-05-23 00:00:00

abstract：:We analysed the effects of morphine microinjections (0.2 microliter) into the subnucleus oralis (SNO), i.e. the rostral division of the spinal trigeminal nucleus, on the formalin test adapted for orofacial pain. Duration of rubbing following an injection (50 microliters) of formalin solution (1.5%) in the right upper ...

journal_title：Neuroreport

authors： Luccarini P,Cadet R,Saade M,Woda A

更新日期：1995-01-26 00:00:00

abstract：:We studied the distribution of phosphorylated tau (p-tau) in neonatal and adult rat cerebrum using monoclonal antibodies that recognize distinct tau epitopes in a phosphorylation-dependent manner. In neonatal cortex, p-tau was detected in the apical dendrites and somata of pyramidal neurons as well as in axons. In adu...

journal_title：Neuroreport

authors： Tashiro K,Hasegawa M,Ihara Y,Iwatsubo T

更新日期：1997-08-18 00:00:00

abstract：:Direct application of brain-derived neurotrophic factor (BDNF) to the cut end of axotomized immature motor neurones had only transient survival-promoting effects. Therefore, we have examined whether additional delivery of BDNF with repeated subcutaneous injections (1 mg/ml) could potentiate this short-term rescue of t...

journal_title：Neuroreport

authors： Vejsada R,Sagot Y,Kato AC

更新日期：1994-10-03 00:00:00

abstract：:The 6-hydroxydopamine rat model of Parkinson's disease was combined with intracerebral drug infusions to examine the influence of glutamate receptors on striatal output activity. When infused into the dopamine-denervated striatum, the AMPA-kainate receptor antagonist DNQX dose-dependently elicited contralateral rotati...

journal_title：Neuroreport

authors： Schuller JJ,Marshall JF

更新日期：1995-12-15 00:00:00

abstract：:Two voltage-activated Na+ channel blockers, lamotrigine and flunarizine were applied ionophoretically to extracellularly recorded dorsal horn neurones to assess effects on activation by noxious (mustard oil) and innocuous (brush) stimuli. Lamotrigine and flunarizine caused significantly greater reductions in mustard o...

journal_title：Neuroreport

authors： Blackburn-Munro G,Fleetwood-Walker SM

更新日期：1997-05-06 00:00:00

abstract：:GLAST is a glial glutamate transporter; mRNA for a splice variant, GLAST1a, which lacks exon 3, has previously been identified. To detect GLAST1a protein, we generated antibodies against a peptide sequence encompassing the splice site. We demonstrate by Western blotting and immunocytochemistry the expression of GLAST1...

journal_title：Neuroreport

authors： Macnab LT,Williams SM,Pow DV

更新日期：2006-12-18 00:00:00

abstract：:NONINVASIVE photolytic injury to targeted neuronal subpopulations in vivo causes unique, slowly progressive neuronal degeneration. To examine the mechanisms of degeneration toward development and transplantation studies, cytosolic calcium levels were measured in vitro from neocortical neurons after incorporation of ph...

journal_title：Neuroreport

authors： Sheen VL,Dreyer EB,Macklis JD

更新日期：1992-08-01 00:00:00

abstract：:Bulbospinal C1 neurons are sympathoexcitatory and excited by substance P. However the substance P receptor (NK1 receptor), has been reported to be absent from the somata of C1 neurons. In this study, using double and triple labelling immunofluorescence and retrograde tracing, we provide evidence that the NK1 receptor ...

journal_title：Neuroreport

authors： Makeham JM,Goodchild AK,Pilowsky PM

更新日期：2001-12-04 00:00:00

abstract：:The early effect of 1-100 microM roscovitine, a purine analogue and cyclin-dependent kinase inhibitor, was studied on tissue specimens from eight human malignant gliomas. The tissue was incubated immediately after resection with DMEM containing [3H]methylthymidine plus vehicle alone or the proper concentration of rosc...

journal_title：Neuroreport

authors： Yakisich JS,Boethius J,Lindblom IO,Wallstedt L,Vargas VI,Sidén A,Cruz MH

更新日期：1999-08-20 00:00:00

abstract：:The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated...

journal_title：Neuroreport

authors： Roberts JA,Gilardi KV,Lasley B,Rapp PR

更新日期：1997-05-27 00:00:00

abstract：:We examined the electrophysiological correlates of the processing of social exclusion and inclusion by using a modified version of the Cyberball paradigm. Exclusion was found to be associated with a significant increase in the P3 complex. The frontal-central P3a was primarily related to the affective processing of rej...

journal_title：Neuroreport

authors： Gutz L,Küpper C,Renneberg B,Niedeggen M

更新日期：2011-06-22 00:00:00

abstract：:It is known that interleukin-1beta facilitates pain, but the mechanisms of this are not understood. This study investigated the role of interleukin-1beta in the expression of Fos, a marker of neuronal activation, and hyperalgesia caused by injecting complete Freund's adjuvant into one hind paw of the rat. Interleukin-...

journal_title：Neuroreport

authors： Li A,Lao L,Wang Y,Zhang H,Ren K,Berman BM,Zhang R

更新日期：2007-03-26 00:00:00

abstract：:By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative an...

journal_title：Neuroreport

authors： Sasaki M,Shibata E,Tohyama K,Kudo K,Endoh J,Otsuka K,Sakai A

更新日期：2008-11-19 00:00:00

abstract：:The first step in olfactory transduction is the recognition of odor molecules by membrane bound receptors belonging to the superfamily of G-protein coupled receptors; other members of this family are involved in neurotransmission. Based on the considerable homology between individual members of this family, we have in...

journal_title：Neuroreport

authors： Firestein S,Shepherd GM

更新日期：1992-08-01 00:00:00

abstract：:The balance between heat production (metabolism) and heat removal (blood flow) helps in keeping the temperature of the brain constant. In patients with moyamoya disease, this balance may be disturbed. The purpose of this study was to assess the thermal pathophysiology of the brain in patients with moyamoya disease. Th...

journal_title：Neuroreport

authors： Yamada K,Sakai K,Akazawa K,Yuen S,Sugimoto N,Sasajima H,Mineura K,Nishimura T

更新日期：2010-09-15 00:00:00

abstract：:In order to ascertain whether disturbances of neurogenesis occur in chronic neurodegenerative disorders, we assessed hippocampal cell proliferation in the R6/1 transgenic mouse model of Huntington's disease (HD). Using BrdU labelling for dividing cells at two different time points (5 and 20 weeks) in transgenic and wi...

journal_title：Neuroreport

authors： Lazic SE,Grote H,Armstrong RJ,Blakemore C,Hannan AJ,van Dellen A,Barker RA

更新日期：2004-04-09 00:00:00

abstract：:Evoked magnetic fields over the entire head were measured during a semantic judgment task, in which conditions of the pre-test learning session were manipulated. Subjects learnt related and unrelated category-noun pairs, and were then asked to judge the relationship between category and noun. Unrelated pairs evoked ac...

journal_title：Neuroreport

authors： Suzuki K,Okuda J,Otsuka Y,Sugawara A,Hatanaka K,Nakasato N,Kanno A,Yoshimoto T,Fujii T,Yamadori A

更新日期：2001-02-12 00:00:00

abstract：:Aminoglycoside ototoxicity is a well-documented process via several pathophysiological pathways. The protective role of cochlear dopamine, released from the lateral olivocochlear efferents, was implicated previously in case of ischemia or acoustic trauma, as it postsynaptically inhibits the effect of excessively relea...

journal_title：Neuroreport

authors： Gáborján A,Halmos G,Répássy G,Vizi ES

更新日期：2001-10-29 00:00:00

abstract：:A double-stranded DNA end-binding factor with high levels of expression in brain and testis of adult mice was identified as the Ku protein, earlier described as an autoantigen in connective tissue diseases and found to be essential for recombination of the immunoglobulin genes and DNA repair. High Ku levels were found...

journal_title：Neuroreport

authors： Bakalkin G,Yakovleva T,Hurd YL,Nussenzweig A,Li GC,Terenius L

更新日期：1998-06-22 00:00:00

abstract：:This study was designed to investigate the expression of transient receptor potential melastatin 3 (TRPM3) and transient receptor potential vanilloid type 4 (TRPV4) in the trigeminal spinal subnucleus caudalis of a rat model of trigeminal neuralgia (TN). The influence of botulinum toxin type A (BTX-A) on the expressio...

journal_title：Neuroreport

authors： Zhang Y,Su Q,Lian Y,Chen Y

更新日期：2019-07-03 00:00:00

abstract：:We have recently characterized a form of ex vivo depotentiation (depotentiationex vivo), which correlates tightly with fear extinction, at thalamic input synapses onto the lateral amygdala. Here, we examined the effects of learning-attenuating drugs, reported to impair fear extinction when microinjected into the basol...

journal_title：Neuroreport

authors： Kim J,Park S,Lee S,Choi S

更新日期：2009-03-25 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in drug tolerance and regulating pain. The purpose of the present study is to explore the regulatory mechanism of miR-124-3p on dezocine tolerance against pain in a rat model. The expression of miR-124-3p and TRAF6 in spinal cord of rats was detected by quantitative reverse-tran...

journal_title：Neuroreport

authors： Huo Y,Zhang K,Zhang T,Han Y,Hu Z

更新日期：2021-01-06 00:00:00

abstract：:Regional cerebral blood flow was measured with positron emission tomography in seven normal volunteers while they performed various script event verification tasks. The left frontal lobe, left anterior cingulate and the anterior part of the left superior temporal gyrus were more activated in the script event membershi...

journal_title：Neuroreport

authors： Partiot A,Grafman J,Sadato N,Flitman S,Wild K

更新日期：1996-02-29 00:00:00

abstract：:The aim of the present study was to determine if both inactivating and non-inactivating potassium currents occur in skeletal muscle cells at early times in culture. Whole cell current was recorded from embryonic muscle cells within 4-10 h of plating. We found that in the cells which had an outward current, half had a ...

journal_title：Neuroreport

authors： Moody-Corbett F,Gilbert R

更新日期：1992-04-01 00:00:00

abstract：:Hydroxyindole-O-methyltransferase (HIOMT), is the last enzyme of the melatonin biosynthesis pathway. We have applied immunocytochemistry and in situ hybridization to localize HIOMT producing cells, in the chicken epithalamus including the pineal gland. The selectivity of the hybridization signal over melatoninergic ce...

journal_title：Neuroreport

authors： Grève P,Bernard M,Voisin P,Cogné M,Collin JP,Guerlotte J

更新日期：1993-06-01 00:00:00

abstract：:A novel allograft paradigm was used to test whether adult mammalian central axons regenerate within a peripheral nerve environment containing intact sensory axons. Retinal ganglion cell axon regeneration was compared following anastomosis of dorsal root ganglia grafts or conventional peripheral nerve grafts to the adu...

journal_title：Neuroreport

authors： King C,Bartlett C,Sauvé Y,Lund R,Dunlop S,Beazley L

更新日期：2006-02-06 00:00:00

abstract：:In the absence of vision of the limb, movements toward a visual target exhibit substantial errors which are considered to originate mainly in the visuomotor transformation process. To determine the time-dependent property of human visuomotor transformation, we investigated the error sequences in movements toward visua...

journal_title：Neuroreport

authors： Miyazaki M,Nakajima Y,Kadota H,Chitose K,Ohtsuki T,Kudo K

更新日期：2004-05-19 00:00:00

abstract：:The whole-cell patch clamp technique was used to investigate the actions of the opioid agonist U50488H on Ca2+ and K+ currents in differentiated NG108-15 cells. U50488H (5-50 microM) caused a concentration-dependent, reversible inhibition of high voltage-activated Ca2+ currents which persisted in the presence of nifed...

journal_title：Neuroreport

authors： Carpenter E,Gent JP,Peers C

更新日期：1996-07-29 00:00:00

abstract：:Functional neuroimaging studies of handedness have traditionally focused on exploring regionally activated discrepancies, yet little is known regarding the effect of handedness on functional connections of brain regions. Here, we reported the relationship between cerebellar functional connectivity patterns and handedn...

journal_title：Neuroreport

authors： He Y,Zang Y,Jiang T,Gong G,Xie S,Xiao J

更新日期：2006-01-23 00:00:00