Abstract:
:The present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to the sensitive to aging, and reproductive status was evaluated according to menstrual cyclicity and urinary hormone profiles. Peri-/postmenopausal monkeys exhibited significant DR impairments relative to either age-matched premenopausal females, or young control subjects. In addition, markers of endocrine decline in the aged animals were selectively correlated with behavioral performance measures that distinguished premenopausal and peri-/postmenopausal monkeys. These results document that menopause is coupled to cognitive decline in the monkey, and they establish a valuable primate model for defining the effects of endocrine aging on brain and behavioral function.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Roberts JA,Gilardi KV,Lasley B,Rapp PRdoi
10.1097/00001756-199705260-00048subject
Has Abstractpub_date
1997-05-27 00:00:00pages
2047-51issue
8eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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