Basal forebrain neurons adjacent to the globus pallidus co-express GABAergic and cholinergic marker mRNAs.

Abstract:

:Semi-quantitative single cell RT-PCR techniques were used to determine the expression of mRNAs related to GABAergic and cholinergic neurotransmission in neurons of the rat globus pallidus and adjacent basal forebrain region. Neurons of the globus pallidus expressed relatively high levels of GAD67 and GABA vesicular transporter mRNA but undetectable levels of ChAT or ACh vesicular transporter mRNA. In contrast, nominally basal forebrain neurons co-expressed ChAT and GAD67 mRNAs and mRNAs for both ACh and GABA vesicular transporters. These results suggest that the neurons along the medial border of the globus pallidus may co-release GABA and ACh.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Tkatch T,Baranauskas G,Surmeier DJ

doi

10.1097/00001756-199806220-00004

subject

Has Abstract

pub_date

1998-06-22 00:00:00

pages

1935-9

issue

9

eissn

0959-4965

issn

1473-558X

journal_volume

9

pub_type

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