Abstract:
:Two groups of hemiparkinsonian rats received grafts of embryonic ventral mesencephalon with or without the addition of the NMDA receptor antagonist (+)dizocilpine hydrogen maleate (MK-801). When added to the cell suspension, a 10 microM concentration of MK-801 did not enhance the survival of tyrosine hydroxylase positive neurones in the grafts. These findings suggest that cell death occurring during nigral transplantation is not primarily due to excitotoxicity.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Schierle GS,Karlsson J,Brundin Pdoi
10.1097/00001756-199805110-00011subject
Has Abstractpub_date
1998-05-11 00:00:00pages
1313-6issue
7eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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