Abstract:
:Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extracellular recordings of firing responses after single pulse stimuli were made. The high-frequency conditioning stimulus increased the A beta- and C-fibre-mediated firing responses to single pulse stimuli by 60 and 130%, respectively, for more than 6 h. This finding supports a role for WDR neurons in 'nociceptive memory' in the dorsal horn. The model presented here may be an important tool for further investigations of mechanisms of plasticity within the dorsal horn.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Svendsen F,Tjølsen A,Hole Kdoi
10.1097/00001756-199711100-00002subject
Has Abstractpub_date
1997-11-10 00:00:00pages
3427-30issue
16eissn
0959-4965issn
1473-558Xjournal_volume
8pub_type
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