LTP of spinal A beta and C-fibre evoked responses after electrical sciatic nerve stimulation.


:Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extracellular recordings of firing responses after single pulse stimuli were made. The high-frequency conditioning stimulus increased the A beta- and C-fibre-mediated firing responses to single pulse stimuli by 60 and 130%, respectively, for more than 6 h. This finding supports a role for WDR neurons in 'nociceptive memory' in the dorsal horn. The model presented here may be an important tool for further investigations of mechanisms of plasticity within the dorsal horn.






Svendsen F,Tjølsen A,Hole K




Has Abstract


1997-11-10 00:00:00












  • Ultrastructural localization of activated NF-kappaB in granule cells of the rat fascia dentata.

    abstract::The distribution of activated NF-kappaB (p65) was studied in granule cells of the rat fascia dentata using confocal laser scanning microscopy and preembedding immunogold electron microscopy. Activated NF-kappaB, detected with a monoclonal antibody specific for the nuclear localization signal-epitope, was found in prox...


    pub_type: 杂志文章


    authors: Kaltschmidt B,Deller T,Frotscher M,Kaltschmidt C

    更新日期:2000-03-20 00:00:00

  • NADPH-diaphorase expression in neurones and glial cells of the locust brain.

    abstract::Using NADPH-diaphorase (NADPH-d) staining as a marker for the enzyme nitric oxide synthase (NOS) we investigated the possible sites of nitric oxide (NO) synthesis in the olfactory pathways of an insect brain. Staining of frozen sections revealed NADPH-d activity in neurones and in glial cells. A cluster of intensely s...


    pub_type: 杂志文章


    authors: Bicker G,Hähnlein I

    更新日期:1995-01-26 00:00:00

  • Left-hemisphere dominance for processing of vowels: a whole-scalp neuromagnetic study.

    abstract::Brain activation of 11 healthy right-handed subjects was studied with magnetoencephalography to estimate individual hemispheric dominance for speech sounds. The auditory stimuli comprised binaurally presented Finnish vowels, tones, and piano notes in groups of two or four stimuli. The subjects were required to detect ...


    pub_type: 临床试验,杂志文章


    authors: Gootjes L,Raij T,Salmelin R,Hari R

    更新日期:1999-09-29 00:00:00

  • Valence processing of first impressions in the dorsomedial prefrontal cortex: a near-infrared spectroscopy study.

    abstract::Previous studies have suggested that the dorsomedial prefrontal cortex (dmPFC) plays a central role in processing first impressions; however, little is known about how dmPFC processes different valences of first impressions. Moreover, it is still unclear as to whether the dmPFC shows lateralization or only induces dif...


    pub_type: 杂志文章


    authors: Yu CL,Wang MY,Hu JF

    更新日期:2016-05-25 00:00:00

  • Impaired discrimination learning in interneuronal NMDAR-GluN2B mutant mice.

    abstract::Previous studies have established a role for N-methyl-D-aspartate receptor (NMDAR) containing the GluN2B subunit in efficient learning behavior on a variety of tasks. Recent findings have suggested that NMDAR on GABAergic interneurons may underlie the modulation of striatal function necessary to balance efficient acti...


    pub_type: 杂志文章


    authors: Brigman JL,Daut RA,Saksida L,Bussey TJ,Nakazawa K,Holmes A

    更新日期:2015-06-17 00:00:00

  • Neuronal coding of stimulus-response association rules in the motor cortex.

    abstract::Two monkeys were trained to perform wrist movements to align a pointer with visual targets. In the spatially 'compatible' condition, monkeys had to point at the target position (left/right), whereas in the 'incompatible' condition, they had to point at the position opposite to the target. A large proportion of neurone...


    pub_type: 杂志文章


    authors: Riehle A,Kornblum S,Requin J

    更新日期:1994-12-20 00:00:00

  • Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats.

    abstract::Spinal cord injury (SCI) causes motor dysfunction and depression, which hinders the recovery of motor function. Body weight-supported treadmill training (BWSTT) should be considered an effective method for functional rehabilitation after SCI, as it is an efficacious intervention in healthcare with no side effects. Bec...


    pub_type: 杂志文章


    authors: Liu CH,Zhao BL,Li WT,Zhou XH,Jin Z,An LB

    更新日期:2020-12-16 00:00:00

  • Phenylketonuria-related synaptic changes in a BTBR-Pah(enu2) mouse model.

    abstract::Phenylketonuria is the most common, inherited aminoacidopathy associated with brain injury. To date, no study has focused on the neuropathology of the genetic mouse model of phenylketonuria, BTBR-Pah(enu2). We examined dendritic spines and synapses in the CA1 and prefrontal cortex among the wild-type, heterozygous, an...


    pub_type: 杂志文章


    authors: Liang L,Gu X,Lu L,Li D,Zhang X

    更新日期:2011-08-24 00:00:00

  • Metabotropic purinoreceptors in rat dorsal horn neurones: predominant dendritic location.

    abstract::Elevations of cytosolic free Ca2+ concentration ([Ca2+]i) induced by addition of ATP have been compared in rat dorsal horn neurones in slices and after their isolation. ATP application induced in neurones in situ a rise of [Ca2+]i by 201 +/- 12 nM. In Ca2+-free external solution the rise was 156 +/- 14 nM (n = 45 of 7...


    pub_type: 杂志文章


    authors: Kruglikov I,Shutov L,Potapenko E,Voitenko N,Kostyuk P

    更新日期:2001-11-16 00:00:00

  • Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease.

    abstract::In this study we have used the transgenic mouse model Tg2576 to analyze the involvement of anomalous loss of regulation of cdk5 and the stress kinases JNK and p38 in brain neuronal death as related to neurodegenerative disorders such as Alzheimer's disease. Previous studies on hippocampal cells led us to the discovery...


    pub_type: 杂志文章


    authors: Otth C,Mendoza-Naranjo A,Mujica L,Zambrano A,Concha II,Maccioni RB

    更新日期:2003-12-19 00:00:00

  • Sensory funneling of liminal multiple- point air-puff stimulation produces dramatic reduction in reaction time but relatively invariant P300 somatosensory evoked potential.

    abstract::Sensory funneling of liminal multiple-point air-puff stimulation on the skin was evaluated by measuring somatosensory evoked potentials (SEPs), reaction time (RT) and subjective detection threshold. Single-point air-puffs at the threshold intensity, and 2-point and 3-point air-puffs (10 mm apart) of the same intensity...


    pub_type: 杂志文章


    authors: Hashimoto I,Yoshikawa K,Kimura T

    更新日期:1999-10-19 00:00:00

  • Phonetic invariance in the human auditory cortex.

    abstract::Neuromagnetic signals evoked by synthesized syllables (/bae/ and /gae/) were recorded over the left auditory cortex of healthy humans. The fundamental frequencies of the syllables varied as if the same speaker had pronounced them at 16 different pitches. Specific mismatch responses to infrequent syllables among freque...


    pub_type: 杂志文章


    authors: Aulanko R,Hari R,Lounasmaa OV,Näätänen R,Sams M

    更新日期:1993-09-30 00:00:00

  • Emotional appraisal processing of computer-generated facial expressions: an functional near-infrared spectroscopy study.

    abstract:OBJECTIVE:The current study aims to investigate whether computer generated (CG) expressions of emotion evoke similar emotional appraisal processing in the lateral orbitofrontal cortex (lOFC) compared to real human expressions, as well as how speech cues would influence the processing. METHODS:Functional near-infrared ...


    pub_type: 杂志文章


    authors: Zhao T,Chen J,Wang L,Yan N

    更新日期:2020-04-08 00:00:00

  • Automatic grapheme processing in the left occipitotemporal cortex.

    abstract::In a previous event-related fMRI study, we showed that the left occipitotemporal cortex was specifically involved in the abstract categorization of visually presented alphabetic symbols. Here, we duplicate the fMRI study by measuring visual event-related potentials to verify whether the left posterior cortex supports ...


    pub_type: 杂志文章


    authors: Gros H,Doyon B,Rioual K,Celsis P

    更新日期:2002-06-12 00:00:00

  • Maternal behavior: activation of the central oxytocin receptor system in parturient rats?

    abstract::Parturition plays a critical role in the full expression of maternal behavior in postpartum females, yet the precise mechanism remains unclear. Here we examined the role of parturition in the activation of Fos and FosB in the central oxytocin receptor (OTR) system in rats. Although expression of FosB, not Fos, was see...


    pub_type: 杂志文章


    authors: Lin SH,Kiyohara T,Sun B

    更新日期:2003-08-06 00:00:00

  • Can color changes alter the neural correlates of recognition memory? Manipulation of processing affects an electrophysiological indicator of conceptual implicit memory.

    abstract::It has been widely shown that recognition memory includes two distinct retrieval processes: familiarity and recollection. Many studies have shown that recognition memory can be facilitated when there is a perceptual match between the studied and the tested items. Most event-related potential studies have explored the ...


    pub_type: 杂志文章


    authors: Cui X,Gao C,Zhou J,Guo C

    更新日期:2016-09-28 00:00:00

  • Anxiolytic-like actions of anpirtoline in a mouse light-dark aversion paradigm.

    abstract::The anxiolytic-like potential of anpirtoline was assessed in a mouse light/dark aversion test. Anpirtoline (1.0 ng kg(-1)-1.0 micrograms kg-1 i.p.) reduced the aversive responding of mice. This was detected as an increase in the latency to locate the non-aversive compartment and by decreases in the percentage of the t...


    pub_type: 杂志文章


    authors: Metzenauer P,Barnes NM,Costall B,Gozlan H,Hamon M,Kelly ME,Murphy DA,Naylor RJ

    更新日期:1992-06-01 00:00:00

  • An ignoring task improves validity of cortical evoked response audiometry.

    abstract::This study examined the basis for introducing an ignoring task during cortical evoked response audiometry (CERA) using the N1-P2 response. Healthy hearing participants were assigned to two groups with and without an ignoring task (ignoring and listening groups) during CERA whose outcomes were compared with the pure-to...


    pub_type: 杂志文章


    authors: Ikeda K,Hayashi A,Matsuda O,Sekiguchi T

    更新日期:2010-07-14 00:00:00

  • Apoptosis in metabolic myopathies.

    abstract::DNA fragmentation, the hallmark of apoptosis, has been recently investigated with contradictory results in several skeletal muscle disorders. Using in situ labeling of nuclear DNA fragmentation, we have tested the possibility that apoptosis might occur in muscles from patients with mitochondrial respiratory chain defe...


    pub_type: 杂志文章


    authors: Monici MC,Toscano A,Girlanda P,Aguennouz M,Musumeci O,Vita G

    更新日期:1998-07-13 00:00:00

  • Sex differences in the posteromedial cortical nucleus of the amygdala in the rat.

    abstract::It has been hypothesized that the vomeronasal system (VNS), a complex neural network implicated in the control of reproductive behaviors, is sexually dimorphic. The posteromedial cortical amygdaloid nucleus (PMCo) belongs to the group of amygdaloid structures that receive direct olfactory input from the accessory olfa...


    pub_type: 杂志文章


    authors: Vinader-Caerols C,Collado P,Segovia S,Guillamón A

    更新日期:1998-08-03 00:00:00

  • On the origin of Alzheimer's disease: a hypothesis.

    abstract::There is no unifying hypothesis to account for the anatomical distribution of neuropathology, the involvement of beta-amyloid precursor protein (beta APP) and the role of increasing age in triggering the Alzheimer disease process. We report here that layer II pre-alpha neurones in transentorhinal and entorhinal cortex...


    pub_type: 杂志文章


    authors: Roberts GW,Nash M,Ince PG,Royston MC,Gentleman SM

    更新日期:1993-01-01 00:00:00

  • Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution.

    abstract::A fundamental issue in neuronal and glial cells is how intracellular rises in Ca2+ are coupled to signaling cascades and changes in subcellular morphology. We studied the expression and localization of annexin VII (synexin), a Ca(2+)-/GTP-dependent membrane fusion protein, in the human CNS. Here, we demonstrate the pr...


    pub_type: 杂志文章


    authors: Clemen CS,Herr C,Lie AA,Noegel AA,Schröder R

    更新日期:2001-05-08 00:00:00

  • 'Prepulse inhibition' facilitates a liberal response bias in an auditory discrimination task.

    abstract::This study examined 'prepulse inhibition' in the context of an auditory two-tone discrimination task performed by 15 healthy subjects. In order to distinguish between masking or excitatory information processes, weak acoustic pulses immediately preceded or succeeded a target or non-target tone in the discrimination. B...


    pub_type: 临床试验,杂志文章


    authors: Schall U,Ward PB

    更新日期:1996-01-31 00:00:00

  • Time-dependent changes in striatal xCT protein expression in hemi-Parkinson rats.

    abstract::Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was inv...


    pub_type: 杂志文章


    authors: Massie A,Schallier A,Mertens B,Vermoesen K,Bannai S,Sato H,Smolders I,Michotte Y

    更新日期:2008-10-29 00:00:00

  • Spinal cord stimulation postconditioning reduces microglial activation through down-regulation of ERK1/2 phosphorylation during spinal cord ischemic reperfusion in rabbits.

    abstract::Microglial activation plays a critical role in spinal cord ischemic reperfusion injury. Spinal cord stimulation preconditioning and postconditioning has shown spinal cord protection in ischemic reperfusion injury in animal studies. However, whether spinal cord stimulation could reduce microglial activation is still un...


    pub_type: 杂志文章


    authors: Dong X,Li H,Lu J,Yang Y,Jing H,Cheng Y,Jin M,Cheng W

    更新日期:2018-09-26 00:00:00

  • Transplantation of bone marrow stromal cells into the cochlea of chinchillas.

    abstract::This study aimed to evaluate the potential of bone marrow stromal cells for treatment of inner ear diseases. Autologous marrow cells labeled with Dil were implanted into the inner ear of five gentamicin-treated chinchillas. Histological analysis 3 weeks later revealed robust survival of grafted marrow cells in multipl...


    pub_type: 杂志文章


    authors: Naito Y,Nakamura T,Nakagawa T,Iguchi F,Endo T,Fujino K,Kim TS,Hiratsuka Y,Tamura T,Kanemaru S,Shimizu Y,Ito J

    更新日期:2004-01-19 00:00:00

  • Do seizures cause neuronal damage? A MRI study in newly diagnosed and chronic epilepsy.

    abstract::It is a matter of dispute whether or not recurrent epileptic seizures cause neuronal damage in the human brain. We approached this question by measuring the volumes of the amygdala, hippocampus and parahippocampal gyrus with magnetic resonance imaging in 15 controls, 13 unmedicated patients with newly diagnosed epilep...


    pub_type: 杂志文章


    authors: Saukkonen A,Kälviäinen R,Partanen K,Vainio P,Riekkinen P,Pitkänen A

    更新日期:1994-12-30 00:00:00

  • Selective death of cholinergic neurons induced by beta-methylamino-L-alanine.

    abstract::Beta-N-methylamino-L-alanine (BMAA) is a nonprotein amino acid that may be involved in neurodegenerative diseases. It is produced by a large variety of cyanobacteria and is found at high levels in the brains of Alzheimer's disease and amyotrophic lateral sclerosis patients. Although BMAA is clearly a neurotoxin, previ...


    pub_type: 杂志文章


    authors: Liu XQ,Rush T,Ciske J,Lobner D

    更新日期:2010-01-06 00:00:00

  • MK-801 reinstates drug-seeking behaviour in cocaine-trained rats.

    abstract::We evaluated the incentive motivational properties of MK-801 by determining its priming effect on drug-seeking behaviour following extinction of cocaine self-administration, an animal model for drug craving. Rats were allowed to self-administrate cocaine (0.5 mg/kg) or saline during 10 daily sessions. MK-801 (0.1-0.25...


    pub_type: 杂志文章


    authors: De Vries TJ,Schoffelmeer AN,Binnekade R,Mulder AH,Vanderschuren LJ

    更新日期:1998-03-09 00:00:00

  • White matter integrity and math performance in pediatric multiple sclerosis: a diffusion tensor imaging study.

    abstract::Multiple sclerosis is associated with reduced white matter integrity and deficits in key cognitive processes important for arithmetic. This study examined the relationship between white matter microstructure and academic ability in 31 youths with multiple sclerosis (aged 11-19 years) and 34 demographically matched con...


    pub_type: 杂志文章


    authors: Till C,Deotto A,Tipu V,Sled JG,Bethune A,Narayanan S,Arnold DL,Banwell BL

    更新日期:2011-12-21 00:00:00