LTP of spinal A beta and C-fibre evoked responses after electrical sciatic nerve stimulation.

Abstract:

:Plasticity in the central nervous system may play an important role in clinical pain. The present study shows that long-term potentiation (LTP) may be induced in single wide dynamic range (WDR) neurons in the dorsal horn after high-frequency stimulation of the sciatic nerve in intact urethane anaesthetized rats. Extracellular recordings of firing responses after single pulse stimuli were made. The high-frequency conditioning stimulus increased the A beta- and C-fibre-mediated firing responses to single pulse stimuli by 60 and 130%, respectively, for more than 6 h. This finding supports a role for WDR neurons in 'nociceptive memory' in the dorsal horn. The model presented here may be an important tool for further investigations of mechanisms of plasticity within the dorsal horn.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Svendsen F,Tjølsen A,Hole K

doi

10.1097/00001756-199711100-00002

subject

Has Abstract

pub_date

1997-11-10 00:00:00

pages

3427-30

issue

16

eissn

0959-4965

issn

1473-558X

journal_volume

8

pub_type

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