Abstract:
:The distribution and cellular localization of the somatostatin sst2(a) receptor was investigated in selected human brain areas using an anti-peptide antibody raised against a carboxy-terminal portion of the receptor protein. The sst2(a) receptor was found to be present on neurones and processes in the deep layers of the cerebral cortex, in the subicular complex and the hippocampal formation. Further signals were obtained in the molecular and granular layer of the cerebellum, with occasional weakly stained Purkinje cells. The regional distribution of the receptor protein was compared with quantitative autoradiography using a sst2 receptor selective ligand [125I]BIM23027.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Schindler M,Holloway S,Humphrey PP,Waldvogel H,Faull RL,Berger W,Emson PCdoi
10.1097/00001756-199802160-00027subject
Has Abstractpub_date
1998-02-16 00:00:00pages
521-5issue
3eissn
0959-4965issn
1473-558Xjournal_volume
9pub_type
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