Diversity of aquaporin mRNA expressed by rat and human retinas.

Abstract:

:Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels. However, it is not known which subtypes of aquaporins are expressed in the mammalian retina. Using RT-PCR, we found that both human and rat retinas express mRNA for a diversity of water channel proteins. The human retina expresses mRNAs for AQP0 to AQP12 proteins. Using real-time PCR, we found that the mRNAs for AQP4 and Kir4.1 are downregulated in retinas that were obtained from patients with proliferative retinopathy compared with post-mortem controls. The data suggest that the development of proliferative gliosis is accompanied by disturbed transglial water and ion movements.

journal_name

Neuroreport

journal_title

Neuroreport

authors

Tenckhoff S,Hollborn M,Kohen L,Wolf S,Wiedemann P,Bringmann A

doi

10.1097/00001756-200501190-00013

subject

Has Abstract

pub_date

2005-01-19 00:00:00

pages

53-6

issue

1

eissn

0959-4965

issn

1473-558X

pii

00001756-200501190-00013

journal_volume

16

pub_type

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