Abstract:
:Muller glial cells of the sensory retina mediate K+ and water fluxes that are facilitated by aquaporin-4 (AQP4) water channels and by Kir4.1-K+ channels. However, it is not known which subtypes of aquaporins are expressed in the mammalian retina. Using RT-PCR, we found that both human and rat retinas express mRNA for a diversity of water channel proteins. The human retina expresses mRNAs for AQP0 to AQP12 proteins. Using real-time PCR, we found that the mRNAs for AQP4 and Kir4.1 are downregulated in retinas that were obtained from patients with proliferative retinopathy compared with post-mortem controls. The data suggest that the development of proliferative gliosis is accompanied by disturbed transglial water and ion movements.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Tenckhoff S,Hollborn M,Kohen L,Wolf S,Wiedemann P,Bringmann Adoi
10.1097/00001756-200501190-00013subject
Has Abstractpub_date
2005-01-19 00:00:00pages
53-6issue
1eissn
0959-4965issn
1473-558Xpii
00001756-200501190-00013journal_volume
16pub_type
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