Abstract:
:Papaverine is a non-specific vasodilatory drug, which was found to unexpectedly cause opening of the blood-brain barrier (BBB). We studied the expression of two endothelial cell related markers, endothelial barrier antigen (EBA) as a marker of BBB intactness, and matrix metalloproteinase-9 (MMP-9), an extracellular matrix molecule, the activation of which results in BBB opening. Immunoreactivity was quantified after intra-carotid injection of papaverine in rats. BBB opening was identified at 1 h, but had been reversed by 24 h. Reduction in EBA-immunoreactivity occurred at 3 h, whereas MMP-9 was not observed until 24 h. The activation of MMP-9 thus occurred much later than BBB opening, which suggests a different role for MMP-9 when selective and reversible opening of the BBB is produced by pharmacological manipulation.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bhattacharjee AK,Kondoh T,Ikeda M,Kohmura Edoi
10.1097/00001756-200212030-00011subject
Has Abstractpub_date
2002-12-03 00:00:00pages
2217-21issue
17eissn
0959-4965issn
1473-558Xjournal_volume
13pub_type
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