Abstract:
:The potential neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) and neublastin (NBN) against NMDA-induced excitotoxicity were examined in hippocampal brain slice cultures. Recombinant human GDNF (25-100 ng/ ml) or NBN, in medium conditioned by growth of transfected, NBN-producing HiB5 cells, were added to slice cultures I h before exposure to 10 microM NMDA for 48h. Neuronal cell death was monitored, before and during the NMDA exposure, by densitometric measurements of propidium iodide (PI) uptake and loss of Nissl staining. Both the addition of rhGDNF and NBN-containing medium significantly reduced the NMDA-induced PI uptake in the CA1 (p < 0.01), suggesting neuroprotective effects of these factors, beyond their well-known trophic effects on dopaminergic neurons.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Bonde C,Kristensen BW,Blaabjerg M,Johansen TE,Zimmer J,Meyer Mdoi
10.1097/00001756-200012180-00032subject
Has Abstractpub_date
2000-12-18 00:00:00pages
4069-73issue
18eissn
0959-4965issn
1473-558Xjournal_volume
11pub_type
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