Abstract:
:Paraoxonase polymorphisms have been associated with amyotrophic lateral sclerosis (ALS). Paraoxonases are detoxifying enzymes involved in the metabolism of organophosphates. We tested the hypothesis that genetic variation within paraoxonase genes would interact with the environmental exposure to paraoxonase substrates. We used population density in the location of residence of ALS patients as a surrogate marker for environmental exposure. Paraoxonase genotypes at previously associated single nucleotide polymorphisms rs662, rs854560, rs6954345, and rs11981433 were studied in 98 patients from the South East England ALS population-based register. A case-only analysis was carried out and median population density was used to categorize patients into rural or urban environments. We found a significant interaction with population density for marker rs854560 (L55M) in ALS.
journal_name
Neuroreportjournal_title
Neuroreportauthors
Diekstra FP,Beleza-Meireles A,Leigh NP,Shaw CE,Al-Chalabi Adoi
10.1097/WNR.0b013e32831af220subject
Has Abstractpub_date
2009-01-28 00:00:00pages
186-90issue
2eissn
0959-4965issn
1473-558Xjournal_volume
20pub_type
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